Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 1182
TargetGenome polyprotein(HCV)
Schering-Plough Research Institute

LigandPNGBDBM9699((2S)-2-[2-(3-{[(3S,18S)-3-cyclohexyl-2,5-dioxo-12-...)
Affinity DataKi:  15nM ΔG°:  -45.4kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2006
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Schering-Plough Research Institute

LigandPNGBDBM9700(3-{[(3S,18S)-3-cyclohexyl-2,5-dioxo-12-oxa-1,4-dia...)
Affinity DataKi:  21nM ΔG°:  -44.6kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2006
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Schering-Plough Research Institute

LigandPNGBDBM9698(tert-butyl (2S)-2-[2-(3-{[(3S,18S)-3-cyclohexyl-2,...)
Affinity DataKi:  260nM ΔG°:  -38.2kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2006
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Schering-Plough Research Institute

LigandPNGBDBM9693(tert-butyl N-[(1S)-1-cyclohexyl-2-[(3S)-3-({1-[({[...)
Affinity DataKi:  1.20E+3nM ΔG°:  -34.4kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2006
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Schering-Plough Research Institute

LigandPNGBDBM9695(benzyl 2-(3-{[(3S,18S)-3-cyclohexyl-2,5-dioxo-12-o...)
Affinity DataKi:  1.70E+3nM ΔG°:  -33.5kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2006
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Schering-Plough Research Institute

LigandPNGBDBM9697(N-[(benzylcarbamoyl)methyl]-3-{[(3S,18S)-3-cyclohe...)
Affinity DataKi:  2.00E+3nM ΔG°:  -33.1kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2006
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Schering-Plough Research Institute

LigandPNGBDBM9694(3-{[(3S,18S)-3-cyclohexyl-2,5-dioxo-12-oxa-1,4-dia...)
Affinity DataKi:  2.10E+3nM ΔG°:  -33.0kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2006
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Schering-Plough Research Institute

LigandPNGBDBM9696(2-(3-{[(3S,18S)-3-cyclohexyl-2,5-dioxo-12-oxa-1,4-...)
Affinity DataKi:  3.00E+3nM ΔG°:  -32.1kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2006
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Schering-Plough Research Institute

LigandPNGBDBM9692((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataKi:  1.50E+4nM ΔG°:  -28.0kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2006
Entry Details Article
PubMed