Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 50003772
LigandChemical structure of BindingDB Monomer ID 50187442BDBM50187442(1-(6-bromo-5-vinyloxypyridin-3-yl)-[1,5]-diazocane...)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50187445BDBM50187445(1-(6-bromopyridin-3-yl)-[1,5]-diazocane | 1-(6-bro...)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50187455BDBM50187455(1-(6-Bromo-5-vinylpyridin-3-yl)-[1,4]diazepane | 1...)
Affinity DataIC50: 0.640nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50187447BDBM50187447(1-(pyridin-3-yl)-1,5-diazocane | 1-pyridin-3-yl-[1...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50187439BDBM50187439(1-(5-Methoxypyridin-3-yl)-[1,5]diazocane | 1-(5-me...)
Affinity DataIC50: 1nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50187438BDBM50187438(cis-1-(5-propen-1-yloxypyridin-3-yl)-[1,4]diazepan...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50187453BDBM50187453(1-(6-bromo-5-chloropyridin-3-yl)-[1,4]-diazepane |...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50187441BDBM50187441(4-(5-bromo-6-chloropyridin-3-yl)-[1,4]-diazepane |...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50475830BDBM50475830(CHEMBL210643)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50475827BDBM50475827(CHEMBL206988)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50187437BDBM50187437(1-(5-chloropyridin-3-yl)-1,5-diazocane | 1-(5-chlo...)
Affinity DataIC50: 2nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50187454BDBM50187454(1-(5-bromopyridin-3-yl)-1,5-diazocane | 1-(5-Bromo...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50475829BDBM50475829(CHEMBL378629)
Affinity DataIC50: 3nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50475824BDBM50475824(CHEMBL382049)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50475828BDBM50475828(CHEMBL208630)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50475823BDBM50475823(CHEMBL207038)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50475832BDBM50475832(CHEMBL208784)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50475831BDBM50475831(CHEMBL210636)
Affinity DataIC50: 10nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50187459BDBM50187459(5-(1,4-diazepan-1-yl)-2-iodopyridin-3-ol | 5-[1,4]...)
Affinity DataIC50: 22nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50475826BDBM50475826(CHEMBL378444)
Affinity DataIC50: 110nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50187436BDBM50187436(1-(6-bromopyridin-3-yl)piperazine | 1-(6-Bromopyri...)
Affinity DataIC50: 180nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50187448BDBM50187448(1-(6-bromo-5-methoxypyridin-3-yl)piperazine | CHEM...)
Affinity DataIC50: 180nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50187434BDBM50187434(1-(5-(vinyloxy)pyridin-3-yl)piperazine | 1-(5-(vin...)
Affinity DataIC50: 190nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50187433BDBM50187433(1-(5-bromo-6-chloropyridin-3-yl)piperazine | CHEMB...)
Affinity DataIC50: 230nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50187449BDBM50187449(3-chloro-5-(piperidin-3-yloxy)pyridine | (+/-)-3-c...)
Affinity DataIC50: 240nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50475825BDBM50475825(CHEMBL380378)
Affinity DataIC50: 500nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50187451BDBM50187451(1-(5-chloro-6-methylpyridin-3-yl)piperazine | CHEM...)
Affinity DataIC50: 520nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed