Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50018364
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194847BDBM50194847(N-(1-ethylcyclopentyl)-7-(4-fluorophenyl)-2,3-dihy...)
Affinity DataIC50: 0.800nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194829BDBM50194829(7-(2,4-difluorophenyl)-N-(1-ethylcyclopentyl)-2,3-...)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194836BDBM50194836(N-(2-cyclobutylpropan-2-yl)-7-(2,4-difluorophenyl)...)
Affinity DataIC50: 1.40nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194832BDBM50194832(7-(4-fluorophenyl)-N-(3-methylpentan-3-yl)-2,3-dih...)
Affinity DataIC50: 1.5nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194850BDBM50194850(7-(4-fluorophenyl)-N-(1-methylcyclohexyl)-2,3-dihy...)
Affinity DataIC50: 1.60nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194829BDBM50194829(7-(2,4-difluorophenyl)-N-(1-ethylcyclopentyl)-2,3-...)
Affinity DataIC50: 2.30nMAssay Description:Binding affinity to rat 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194828BDBM50194828(N-(2-methyl-1-phenylpropan-2-yl)-7-p-tolyl-2,3-dih...)
Affinity DataIC50: 2.40nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194842BDBM50194842(N-(1-ethylcyclopentyl)-7-(2-fluorophenyl)-2,3-dihy...)
Affinity DataIC50: 3.60nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194845BDBM50194845(7-(2,4-difluorophenyl)-N-(3-ethylpentan-3-yl)-2,3-...)
Affinity DataIC50: 3.70nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194853BDBM50194853(7-(2-fluorophenyl)-N-(2-methyl-1-phenylpropan-2-yl...)
Affinity DataIC50: 3.80nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194834BDBM50194834(N-tert-butyl-7-p-tolyl-2,3-dihydro-1H-1,4-diazepin...)
Affinity DataIC50: 11nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194854BDBM50194854(N-tert-butyl-7-(2,4-difluorophenyl)-2,3-dihydro-1H...)
Affinity DataIC50: 11nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194839BDBM50194839(N-tert-butyl-7-(2-fluoro-4-methylphenyl)-2,3-dihyd...)
Affinity DataIC50: 14nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194830BDBM50194830(7-(2-fluorophenyl)-N-(3-methylpentan-3-yl)-2,3-dih...)
Affinity DataIC50: 14.5nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194833BDBM50194833(N-(3-methylpentan-3-yl)-7-p-tolyl-2,3-dihydro-1H-1...)
Affinity DataIC50: 14.9nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194832BDBM50194832(7-(4-fluorophenyl)-N-(3-methylpentan-3-yl)-2,3-dih...)
Affinity DataIC50: 16nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194855BDBM50194855(N-tert-butyl-7-(2-fluorophenyl)-2,3-dihydro-1H-1,4...)
Affinity DataIC50: 18nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194852BDBM50194852(N-tert-butyl-7-(4-fluorophenyl)-2,3-dihydro-1H-1,4...)
Affinity DataIC50: 21nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194829BDBM50194829(7-(2,4-difluorophenyl)-N-(1-ethylcyclopentyl)-2,3-...)
Affinity DataIC50: 27nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194837BDBM50194837(N-tert-butyl-7-phenyl-2,3-dihydro-1H-1,4-diazepin-...)
Affinity DataIC50: 35nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194831BDBM50194831(N-tert-butyl-7-(2,4-dimethylphenyl)-2,3-dihydro-1H...)
Affinity DataIC50: 71nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194833BDBM50194833(N-(3-methylpentan-3-yl)-7-p-tolyl-2,3-dihydro-1H-1...)
Affinity DataIC50: 75nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194843BDBM50194843(N-tert-butyl-7-(2-chlorophenyl)-2,3-dihydro-1H-1,4...)
Affinity DataIC50: 76nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194845BDBM50194845(7-(2,4-difluorophenyl)-N-(3-ethylpentan-3-yl)-2,3-...)
Affinity DataIC50: 86nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194846BDBM50194846(N-tert-butyl-7-o-tolyl-2,3-dihydro-1H-1,4-diazepin...)
Affinity DataIC50: 112nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194844BDBM50194844(N-tert-butyl-7-(3-(trifluoromethyl)phenyl)-2,3-dih...)
Affinity DataIC50: 514nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194849BDBM50194849(N-tert-butyl-7-(4-methoxyphenyl)-2,3-dihydro-1H-1,...)
Affinity DataIC50: 534nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194852BDBM50194852(N-tert-butyl-7-(4-fluorophenyl)-2,3-dihydro-1H-1,4...)
Affinity DataIC50: 637nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194838BDBM50194838(N,N-diethyl-7-p-tolyl-2,3-dihydro-1H-1,4-diazepin-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194848BDBM50194848(5-morpholino-7-p-tolyl-2,3-dihydro-1H-1,4-diazepin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194841BDBM50194841(N,N-diethyl-7-(2-fluorophenyl)-2,3-dihydro-1H-1,4-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194851BDBM50194851(5-(piperazin-1-yl)-7-p-tolyl-2,3-dihydro-1H-1,4-di...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194837BDBM50194837(N-tert-butyl-7-phenyl-2,3-dihydro-1H-1,4-diazepin-...)
Affinity DataIC50: 1.05E+3nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194840BDBM50194840(7-(2-fluorophenyl)-N-neopentyl-2,3-dihydro-1H-1,4-...)
Affinity DataIC50: 1.52E+3nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194835BDBM50194835(4-(7-(tert-butylamino)-3,4-dihydro-2H-1,4-diazepin...)
Affinity DataIC50: 2.80E+3nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed