Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50018619
TargetNeprilysin(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of rat NEPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of rabbit NEPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50: 2.30nMpH: 7.0Assay Description:Inhibition of human kidney NEP at pH 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197513((S)-2-((1-((2-(hydroxymethyl)-2,3-dihydro-1H-inden...)
Affinity DataIC50: 3.70nMpH: 7.0Assay Description:Inhibition of human kidney NEP at pH 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197519((S)-2-{1-[3-(4-fluoro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50: 4.60nMpH: 7.0Assay Description:Inhibition of human kidney NEP at pH 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human recombinant NEPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197507((S)-4-methoxy-2-{1-[(1R,2S)-2-(4-methoxy-phenyl)-c...)
Affinity DataIC50: 6.10nMpH: 7.0Assay Description:Inhibition of human kidney NEP at pH 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197513((S)-2-((1-((2-(hydroxymethyl)-2,3-dihydro-1H-inden...)
Affinity DataIC50: 10nMpH: 7.4Assay Description:Inhibition of human kidney NEP at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190746((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Affinity DataIC50: 10.2nMAssay Description:Inhibition of rabbit NEPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50: 10.5nMpH: 7.4Assay Description:Inhibition of human kidney NEP at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197519((S)-2-{1-[3-(4-fluoro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50: 12.6nMpH: 7.4Assay Description:Inhibition of human kidney NEP at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197507((S)-4-methoxy-2-{1-[(1R,2S)-2-(4-methoxy-phenyl)-c...)
Affinity DataIC50: 13.8nMpH: 7.4Assay Description:Inhibition of human kidney NEP at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190746((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Affinity DataIC50: 14.3nMAssay Description:Inhibition of rat NEPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190746((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Affinity DataIC50: 18.9nMpH: 7.0Assay Description:Inhibition of human kidney NEP at pH 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190746((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Affinity DataIC50: 19.7nMAssay Description:Inhibition of human recombinant NEPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190746((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Affinity DataIC50: 31.8nMpH: 7.4Assay Description:Inhibition of human kidney NEP at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed