Compile Data Set for Download or QSAR
maximum 50k data
Found 28 Enz. Inhib. hit(s) with all data for entry = 50019081
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201488(CHEMBL239608 | N-(3-bromophenyl)-2-oxo-2,3-dihydro...)
Affinity DataKi:  56nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201496(CHEMBL239592 | N-(3-chlorophenyl)-2-oxo-2,3-dihydr...)
Affinity DataKi:  68nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201484(CHEMBL396691 | N-(6-methylpyridin-2-yl)-2-oxo-2,3-...)
Affinity DataKi:  95nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201492(2-oxo-N-m-tolyl-2,3-dihydrobenzo[d]oxazole-4-carbo...)
Affinity DataKi:  109nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201486(CHEMBL391955 | N-(2-methylthiazol-4-yl)-2-oxo-2,3-...)
Affinity DataKi:  250nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201480(2-oxo-N-(pyridin-2-yl)-2,3-dihydrobenzo[d]oxazole-...)
Affinity DataKi:  251nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201490(CHEMBL391398 | N-(3-cyanophenyl)-2-oxo-2,3-dihydro...)
Affinity DataKi:  327nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201478(CHEMBL239594 | N-(3-chlorophenyl)-2-oxoindoline-7-...)
Affinity DataKi:  397nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201494(2-oxo-N-(3-(trifluoromethyl)phenyl)-2,3-dihydroben...)
Affinity DataKi:  485nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201485(CHEMBL245640 | N-(2-methylpyrimidin-4-yl)-2-oxo-2,...)
Affinity DataKi:  1.97E+3nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201501(2-oxo-N-phenyl-2,3-dihydrobenzo[d]oxazole-4-carbox...)
Affinity DataKi:  2.20E+3nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201500(CHEMBL239595 | N-(3-chlorophenyl)-3-oxo-3,4-dihydr...)
Affinity DataKi:  2.90E+3nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201479(CHEMBL248509 | N-(2-methylpyridin-4-yl)-2-oxo-2,3-...)
Affinity DataKi:  3.10E+3nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201493(CHEMBL247890 | N-(4-chlorophenyl)-2-oxo-2,3-dihydr...)
Affinity DataKi:  3.80E+3nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201489(CHEMBL430387 | N-(3-methoxyphenyl)-2-oxo-2,3-dihyd...)
Affinity DataKi:  3.90E+3nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201498(CHEMBL239602 | N-(3-chlorophenyl)-1H-indole-7-carb...)
Affinity DataKi:  3.90E+3nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201491(CHEMBL239599 | N-(3-chlorophenyl)-2-oxo-2,3-dihydr...)
Affinity DataKi:  3.90E+3nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201495(CHEMBL239604 | N-(3-chlorophenyl)-3H-benzo[d][1,2,...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201481(CHEMBL247080 | N-(3,5-dichlorophenyl)-2-oxo-2,3-di...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201499(CHEMBL393480 | N-(3-chlorophenyl)-3H-benzo[d]imida...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201487(CHEMBL239600 | N-(3-chlorophenyl)-1-methyl-2-oxo-2...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201483(2-acetamido-N-(3-chlorophenyl)benzamide | CHEMBL23...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201497(CHEMBL247888 | N-(2-chlorophenyl)-2-oxo-2,3-dihydr...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201482(CHEMBL239593 | N-(3-chlorophenyl)-2-oxo-2,3-dihydr...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201484(CHEMBL396691 | N-(6-methylpyridin-2-yl)-2-oxo-2,3-...)
Affinity DataIC50:  60nMAssay Description:Antagonist activity at mGluR5 assessed as inhibition of Ca2+ efflux by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201488(CHEMBL239608 | N-(3-bromophenyl)-2-oxo-2,3-dihydro...)
Affinity DataIC50:  94nMAssay Description:Antagonist activity at mGluR5 assessed as inhibition of Ca2+ efflux by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201492(2-oxo-N-m-tolyl-2,3-dihydrobenzo[d]oxazole-4-carbo...)
Affinity DataIC50:  104nMAssay Description:Antagonist activity at mGluR5 assessed as inhibition of Ca2+ efflux by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201496(CHEMBL239592 | N-(3-chlorophenyl)-2-oxo-2,3-dihydr...)
Affinity DataIC50:  195nMAssay Description:Antagonist activity at mGluR5 assessed as inhibition of Ca2+ efflux by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed