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Found 30 Enz. Inhib. hit(s) with all data for entry = 50019271
TargetCaspase-1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203364(CHEMBL248310 | N-((S)-3-(2-(3-(1H-tetrazol-5-ylami...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203361((3S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-butyl-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203364(CHEMBL248310 | N-((S)-3-(2-(3-(1H-tetrazol-5-ylami...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203361((3S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-butyl-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203361((3S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-butyl-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203361((3S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-butyl-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50160976((3S)-3-(2-(5-tert-butyl-3-((4-methyl-1,2,5-oxadiaz...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203365((3S)-3-(2-(5-tert-butyl-3-(2,3-dihydrobenzo[b][1,4...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203366((3S)-3-(2-(5-tert-butyl-2-oxo-3-(2-(thiophen-2-yl)...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203364(CHEMBL248310 | N-((S)-3-(2-(3-(1H-tetrazol-5-ylami...)
Affinity DataIC50:  64.7nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203362((3S)-3-(2-(5-tert-butyl-3-(1-carboxy-3-methylbutyl...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50160976((3S)-3-(2-(5-tert-butyl-3-((4-methyl-1,2,5-oxadiaz...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203363((3S)-3-(2-(3-(3,5-dimethoxybenzylamino)-5-tert-but...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203364(CHEMBL248310 | N-((S)-3-(2-(3-(1H-tetrazol-5-ylami...)
Affinity DataIC50:  164nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203365((3S)-3-(2-(5-tert-butyl-3-(2,3-dihydrobenzo[b][1,4...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203366((3S)-3-(2-(5-tert-butyl-2-oxo-3-(2-(thiophen-2-yl)...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203363((3S)-3-(2-(3-(3,5-dimethoxybenzylamino)-5-tert-but...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203365((3S)-3-(2-(5-tert-butyl-3-(2,3-dihydrobenzo[b][1,4...)
Affinity DataIC50:  330nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203363((3S)-3-(2-(3-(3,5-dimethoxybenzylamino)-5-tert-but...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203366((3S)-3-(2-(5-tert-butyl-2-oxo-3-(2-(thiophen-2-yl)...)
Affinity DataIC50:  920nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203365((3S)-3-(2-(5-tert-butyl-3-(2,3-dihydrobenzo[b][1,4...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203366((3S)-3-(2-(5-tert-butyl-2-oxo-3-(2-(thiophen-2-yl)...)
Affinity DataIC50:  2.31E+3nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203363((3S)-3-(2-(3-(3,5-dimethoxybenzylamino)-5-tert-but...)
Affinity DataIC50:  3.05E+3nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203362((3S)-3-(2-(5-tert-butyl-3-(1-carboxy-3-methylbutyl...)
Affinity DataIC50:  3.49E+3nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50160976((3S)-3-(2-(5-tert-butyl-3-((4-methyl-1,2,5-oxadiaz...)
Affinity DataIC50:  5.13E+3nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50160976((3S)-3-(2-(5-tert-butyl-3-((4-methyl-1,2,5-oxadiaz...)
Affinity DataIC50:  5.29E+3nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203362((3S)-3-(2-(5-tert-butyl-3-(1-carboxy-3-methylbutyl...)
Affinity DataIC50:  5.49E+3nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203364(CHEMBL248310 | N-((S)-3-(2-(3-(1H-tetrazol-5-ylami...)
Affinity DataIC50:  6.07E+3nMAssay Description:Inhibition of human recombinant caspase 3 in NT2 by whole cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203362((3S)-3-(2-(5-tert-butyl-3-(1-carboxy-3-methylbutyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203361((3S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-butyl-...)
Affinity DataIC50:  1.94E+4nMAssay Description:Inhibition of human recombinant caspase 3 in NT2 by whole cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed