Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 50019320
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203626([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203611([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203587([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi:  6.40nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203625(ethyl-[2-methyl-8-(2,4,6-trimethyl-phenyl)-8H-1,3a...)
Affinity DataKi:  7.80nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203598(cyclobutylmethyl-[2-methyl-8-(2,4,6-trimethyl-phen...)
Affinity DataKi:  8.20nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203621(8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-3-(3-phe...)
Affinity DataKi:  8.40nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203590([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203609(allyl-[8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203589(cyclopropylmethyl-[2-methyl-8-(2,4,6-trimethyl-phe...)
Affinity DataKi:  15nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203624([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi:  15nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203610([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi:  15nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203608(cyclopropylmethyl-propyl-[2-trifluoromethyl-8-(2,4...)
Affinity DataKi:  16nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203617(cyclobutylmethyl-[2-ethyl-8-(2,4,6-trimethyl-pheny...)
Affinity DataKi:  17nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203597(dibutyl-[8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl...)
Affinity DataKi:  18nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203599([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi:  20nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203594(bis-cyclopropylmethyl-[2-methyl-8-(2,4,6-trimethyl...)
Affinity DataKi:  23nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203619(diallyl-[2-methyl-8-(2,4,6-trimethyl-phenyl)-8H-1,...)
Affinity DataKi:  26nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203600(benzyl-[8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-...)
Affinity DataKi:  28nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203602(diallyl-[8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl...)
Affinity DataKi:  28nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203588([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi:  36nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203606(butyl-[8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8...)
Affinity DataKi:  36nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203604(allyl-[2-methyl-8-(2,4,6-trimethyl-phenyl)-8H-1,3a...)
Affinity DataKi:  41nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203612((2-cyclopropyl-ethyl)-[2-methyl-8-(2,4,6-trimethyl...)
Affinity DataKi:  43nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203615(3-(2-benzyl-pyrrolidin-1-ylmethyl)-8-(2-chloro-4,6...)
Affinity DataKi:  48nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203614([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi:  50nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203605(cyclopropylmethyl-ethyl-[2-methyl-8-(2,4,6-trimeth...)
Affinity DataKi:  93nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203596([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi:  360nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203613([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi:  570nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203622(8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-3-(2-phe...)
Affinity DataKi:  580nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203592(3-(3-benzyl-pyrrolidin-1-ylmethyl)-8-(2-chloro-4,6...)
Affinity DataKi:  700nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203616(8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-3-(3-phe...)
Affinity DataKi:  700nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203627([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203607(8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-3-(2-phe...)
Affinity DataKi:  1.30E+3nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203620(8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-3-morpho...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203593([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi:  2.70E+3nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203591([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi:  2.80E+3nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203623([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi:  2.90E+3nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203603([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi:  3.20E+3nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203601([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi:  4.10E+3nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203595([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi:  5.60E+3nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50203618([8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed