Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 50000660
TargetDihydrofolate reductase(Mouse)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataKi:  0.00528nMAssay Description:The compound was tested for its inhibitory activity against dihydrofolate reductase(DHFR) derived from L1210 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50008293(CHEMBL114733 | 2-{4-[(2,4-Diamino-pyrido[2,3-d]pyr...)
Affinity DataKi:  0.00585nMAssay Description:The compound was tested for its inhibitory activity against dihydrofolate reductase(DHFR) derived from L1210 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50008292(CHEMBL112061 | 2-{4-[(2,4-Diamino-5-methyl-pyrido[...)
Affinity DataKi:  0.00687nMAssay Description:The compound was tested for its inhibitory activity against dihydrofolate reductase(DHFR) derived from L1210 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50008290(CHEMBL114987 | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-py...)
Affinity DataIC50: 90nMAssay Description:The compound was tested for its inhibitory activity against thymidylate synthase(TS) derived from H35F/F cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50008295(CHEMBL325744 | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-py...)
Affinity DataIC50: 2.40E+3nMAssay Description:The compound was tested for its inhibitory activity against thymidylate synthase(TS) derived from H35F/F cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Lactobacillus casei)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50008291(CHEMBL280145 | 2-{4-[(2-Amino-4-oxo-1,4-dihydro-pt...)
Affinity DataIC50: 3.90E+3nMAssay Description:The compound was tested for its inhibitory activity (IC50) against thymidylate synthase(TS) derived from Lactobacillus caseiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed