Compile Data Set for Download or QSAR
maximum 50k data
Found 11 Enz. Inhib. hit(s) with all data for entry = 50020233
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211499((1S,3R)-N-[3,5-bis(trifluoromethyl)benzyl]-1-methy...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [125]hMCP1 from human CCR2 receptor expressed in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211497((1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [125]hMCP1 from human CCR2 receptor expressed in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211497((1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}...)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced calcium flux in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211502((1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}...)
Affinity DataIC50:  7.5nMAssay Description:Displacement of [125]hMCP1 from human CCR2 receptor expressed in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211503(CHEMBL226376 | cis-(1S,3R)-N-(3,5-bis(trifluoromet...)
Affinity DataIC50:  36nMAssay Description:Displacement of [125]hMCP1 from human CCR2 receptor expressed in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211500((1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}...)
Affinity DataIC50:  47nMAssay Description:Displacement of [125]hMCP1 from human CCR2 receptor expressed in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211497((1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}...)
Affinity DataIC50:  57nMAssay Description:Antagonist activity against human CCR2 receptor in human monocytes assessed as inhibition of chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211498(CHEMBL388308 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  65nMAssay Description:Displacement of [125]hMCP1 from human CCR2 receptor expressed in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211499((1S,3R)-N-[3,5-bis(trifluoromethyl)benzyl]-1-methy...)
Affinity DataIC50:  130nMAssay Description:Displacement of [125]hMCP1 from mouse CCR2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211499((1S,3R)-N-[3,5-bis(trifluoromethyl)benzyl]-1-methy...)
Affinity DataIC50:  630nMAssay Description:Displacement of MIP1alpha from CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211501((1R,4R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [125]hMCP1 from human CCR2 receptor expressed in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed