Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 50020694
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23515BDBM23515(pyridine-3-carboxylic acid | CHEMBL573 | [5, 6-3H]...)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50211362BDBM50211362(5-methyl-3-carboxyl-pyrazole | 5-methyl-1H-pyrazol...)
Affinity DataEC50:  460nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216552BDBM50216552(2-methylthiazole-5-carboxylic acid | CHEMBL247134)
Affinity DataEC50:  500nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216539BDBM50216539(5-ethyl-1H-pyrazole-3-carboxylic acid | 3-ethyl-1H...)
Affinity DataEC50:  800nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50132140BDBM50132140(1,4,5,6-Tetrahydro-cyclopentapyrazole-3-carboxylic...)
Affinity DataEC50:  860nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216533BDBM50216533(5-cyclopropyl-1H-pyrazole-3-carboxylic acid | 3-cy...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50211361BDBM50211361(3-methylisoxazole-5-carboxylic acid | 3-methyl-5-c...)
Affinity DataEC50:  1.30E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50220842BDBM50220842(3-butyl-1H-pyrazole-5-carboxylic acid | 5-butyl-1H...)
Affinity DataEC50:  1.40E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216532BDBM50216532(isothiazole-4-carboxylic acid | CHEMBL393226)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216551BDBM50216551(5-butylpyrazole-3-carboxylic acid | 5-pentyl-1H-py...)
Affinity DataEC50:  1.80E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216523BDBM50216523(6-propyl-4,6-dihydro-2H-furo[3,4-c]pyrazole-3-carb...)
Affinity DataEC50:  2.10E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216527BDBM50216527(5,6-dihydro-2H-thieno[3,2-c]pyrazole-3-carboxylic ...)
Affinity DataEC50:  2.20E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216535BDBM50216535(3-(hydroxymethyl)-1H-pyrazole-5-carboxylic acid | ...)
Affinity DataEC50:  2.50E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216529BDBM50216529(6-methyl-4,6-dihydro-2H-furo[3,4-c]pyrazole-3-carb...)
Affinity DataEC50:  2.50E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50132135BDBM50132135(4,6-dihydro-2H-furo[3,4-c]pyrazole-3-carboxylic ac...)
Affinity DataEC50:  2.70E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50211364BDBM50211364(5-meta-fluorobenzyl-3-carboxyl-pyrazole | 3-(3-flu...)
Affinity DataEC50:  2.80E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216520BDBM50216520(pyrimidine-5-carboxylic acid | CHEMBL247316)
Affinity DataEC50:  2.90E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216547BDBM50216547(3-(methylthiomethyl)-1H-pyrazole-5-carboxylic acid...)
Affinity DataEC50:  3.70E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50220850BDBM50220850(3-propyl-1H-pyrazole-5-carboxylic acid | 5-propyl-...)
Affinity DataEC50:  3.90E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216540BDBM50216540(3-(methylsulfinylmethyl)-1H-pyrazole-5-carboxylic ...)
Affinity DataEC50:  4.90E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216521BDBM50216521(5-fluoronicotinic acid | CHEMBL397783)
Affinity DataEC50:  5.30E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216538BDBM50216538(3-hexyl-1H-pyrazole-5-carboxylic acid | CHEMBL2479...)
Affinity DataEC50:  5.60E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216530BDBM50216530(4,6-dihydro-2H-thieno[3,4-c]pyrazole-3-carboxylic ...)
Affinity DataEC50:  5.60E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216543BDBM50216543(3-formyl-1H-pyrazole-5-carboxylic acid | CHEMBL246...)
Affinity DataEC50:  6.10E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216550BDBM50216550(5-(3-Chloro-benzyl)-1H-pyrazole-3-carboxylic acid ...)
Affinity DataEC50:  6.20E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216541BDBM50216541(CHEMBL613 | Rifater | pyrazinoicacid | PZA | PYRAZ...)
Affinity DataEC50:  6.30E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216536BDBM50216536(6-propyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-3...)
Affinity DataEC50:  6.60E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216546BDBM50216546(5-chloronicotinic acid | CHEMBL395178)
Affinity DataEC50:  7.60E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216525BDBM50216525(6-methyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-3...)
Affinity DataEC50:  8.30E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50211363BDBM50211363(5-isopropyl-3-carboxyl-pyrazole | 5-Isopropyl-1H-p...)
Affinity DataEC50:  8.30E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216548BDBM50216548(6-ethyl-4,6-dihydro-2H-furo[3,4-c]pyrazole-3-carbo...)
Affinity DataEC50:  8.70E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216526BDBM50216526(3-(methoxymethyl)-1H-pyrazole-5-carboxylic acid | ...)
Affinity DataEC50:  8.70E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216537BDBM50216537(3-benzyl-1H-pyrazole-5-carboxylic acid | 5-Benzyl-...)
Affinity DataEC50:  8.90E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50211365BDBM50211365(5-meta-bromobenzyl-3-carboxyl-pyrazole | 3-(3-brom...)
Affinity DataEC50:  1.05E+4nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216528BDBM50216528(6-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-3...)
Affinity DataEC50:  1.20E+4nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216544BDBM50216544(3-(2-methoxyethyl)-1H-pyrazole-5-carboxylic acid |...)
Affinity DataEC50:  1.22E+4nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216531BDBM50216531(5-bromonicotinic acid | CHEMBL247336)
Affinity DataEC50:  1.36E+4nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216534BDBM50216534(5-methylnicotinic acid | CHEMBL247132)
Affinity DataEC50:  1.60E+4nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216524BDBM50216524(3-cyclobutyl-1H-pyrazole-5-carboxylic acid | 5-cyc...)
Affinity DataEC50:  1.62E+4nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216522BDBM50216522(1-methyl-1H-pyrazole-4-carboxylic acid | CHEMBL393...)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216542BDBM50216542(pyridazine-4-carboxylic acid | CHEMBL394068)
Affinity DataEC50:  2.30E+4nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed