Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 50021094
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220886(5-(3-aminopropyl)-7,8-dicyclohexyl-3-methyl-2H-pyr...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM92404(CHEMBL250843 | PDK1 inhibitor, 5)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220898((R)-5-(3-amino-2-fluoropropyl)-7,8-dicyclohexyl-3-...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220884((S)-5-(3-amino-2-fluoropropyl)-7,8-dicyclohexyl-3-...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220890(8-(2-amino-ethanesulfonyl)-5-ethyl-3-methyl-2,5,7,...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220895(5-ethyl-3-methyl-4-oxo-2,4,5,7,9,10-hexahydro-1,2,...)
Affinity DataIC50: 12nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220888(5-(3-amino-2,2-difluoropropyl)-7,8-dicyclohexyl-3-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220892(8-(2-amino-acetyl)-5-ethyl-3-methyl-2,5,7,8,9,10-h...)
Affinity DataIC50: 18nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220893(5-(4-aminobutyl)-8-chloro-3-methyl-2H-pyrazolo[4,3...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220896(3-methyl-2,5-dihydro-1,2,5-triaza-cyclopenta[a]ant...)
Affinity DataIC50: 29nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220887(5-(2-aminoethyl)-8-chloro-3-methyl-2H-pyrazolo[4,3...)
Affinity DataIC50: 36nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220889(8-chloro-3-methyl-2H-pyrazolo[4,3-c]quinolin-4(5H)...)
Affinity DataIC50: 40nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220905(6-(3-aminoprop-1-enyl)-7,8-dicyclohexyl-3-methyl-2...)
Affinity DataIC50: 58nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220894(N-(2-aminoethyl)-8-chloro-3-methyl-2H-pyrazolo[4,3...)
Affinity DataIC50: 60nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220900(3-(8-chloro-3-methyl-2H-pyrazolo[4,3-c]quinolin-4-...)
Affinity DataIC50: 64nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220901(3-methyl-2,5,7,8,9,10-hexahydro-1,2,5-triaza-cyclo...)
Affinity DataIC50: 130nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220899(N-(3-aminopropyl)-8-chloro-3-methyl-2H-pyrazolo[4,...)
Affinity DataIC50: 220nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220903(3,8-dimethyl-2H-pyrazolo[4,3-c]quinolin-4(5H)-one ...)
Affinity DataIC50: 230nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220908(6-(3-aminopropyl)-7,8-dicyclohexyl-3-methyl-2H-pyr...)
Affinity DataIC50: 290nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220907(2-(8-chloro-3-methyl-2H-pyrazolo[4,3-c]quinolin-4-...)
Affinity DataIC50: 850nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220891(3-Methyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one...)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220904(3,6-dimethyl-2H-pyrazolo[4,3-c]quinolin-4(5H)-one ...)
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220885(7-chloro-3-methyl-2H-pyrazolo[4,3-c]quinolin-4(5H)...)
Affinity DataIC50: 1.98E+3nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220886(5-(3-aminopropyl)-7,8-dicyclohexyl-3-methyl-2H-pyr...)
Affinity DataIC50: 5.30E+3nMAssay Description:Binding affinity at hERG expressed in human embryonic kidney cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220902(N-(3-methyl-4-oxo-4,5-dihydro-2H-pyrazolo[4,3-c]qu...)
Affinity DataIC50: 7.08E+3nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220898((R)-5-(3-amino-2-fluoropropyl)-7,8-dicyclohexyl-3-...)
Affinity DataIC50: 1.32E+4nMAssay Description:Binding affinity at hERG expressed in human embryonic kidney cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220906(9-chloro-3-methyl-2H-pyrazolo[4,3-c]quinolin-4(5H)...)
Affinity DataIC50: 2.89E+4nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220909(3,9-dimethyl-2H-pyrazolo[4,3-c]quinolin-4(5H)-one ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed