Compile Data Set for Download or QSAR
maximum 50k data
Found 42 Enz. Inhib. hit(s) with all data for entry = 2742
LigandPNGBDBM24019(1-benzyl-5-methyl-5'-(4-methylphenyl)-1,2-dihydro-...)
Affinity DataIC50:  610nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24008(1-benzyl-5'-(4-methoxyphenyl)-5-methyl-1,2-dihydro...)
Affinity DataIC50:  640nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24006(5'-(4-methoxyphenyl)-6-propyl-1,2-dihydro-3'H-spir...)
Affinity DataIC50:  780nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24007(1-benzyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50:  870nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24009(5'-(4-methoxyphenyl)-5-methyl-1-(2-methylphenyl)-1...)
Affinity DataIC50:  900nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24022(1-benzyl-5'-(4-methoxyphenyl)-5-methyl-6-propyl-1,...)
Affinity DataIC50:  950nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24013(6-chloro-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50:  1.20E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24018(5-methyl-1-(2-methylphenyl)-5'-(4-methylphenyl)-1,...)
Affinity DataIC50:  1.20E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24004(5-ethyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spiro...)
Affinity DataIC50:  1.40E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24012(5'-(4-methoxyphenyl)-6-methyl-1,2-dihydro-3'H-spir...)
Affinity DataIC50:  1.40E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24001(5'-(4-methylphenyl)-6-propyl-1,2-dihydro-3'H-spiro...)
Affinity DataIC50:  1.40E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24021(1-(4-chlorophenyl)-5'-(4-methoxyphenyl)-5-methyl-1...)
Affinity DataIC50:  1.50E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM24006(5'-(4-methoxyphenyl)-6-propyl-1,2-dihydro-3'H-spir...)
Affinity DataIC50:  1.70E+3nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24000(5-ethyl-5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro[...)
Affinity DataIC50:  1.90E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24005(5-chloro-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50:  2.00E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24010(5-bromo-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spiro...)
Affinity DataIC50:  2.40E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24003(5'-(4-methoxyphenyl)-5-methyl-1,2-dihydro-3'H-spir...)
Affinity DataIC50:  2.50E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24016(1,5'-diphenyl-1,2-dihydro-3'H-spiro[indole-3,2'-[1...)
Affinity DataIC50:  2.60E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM23999(5-methyl-5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro...)
Affinity DataIC50:  3.00E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24015(5'-phenyl-1-(propan-2-yl)-1,2-dihydro-3'H-spiro[in...)
Affinity DataIC50:  3.10E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM23998(5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro[indole-3...)
Affinity DataIC50:  3.70E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24011(5'-(4-methoxyphenyl)-5-nitro-1,2-dihydro-3'H-spiro...)
Affinity DataIC50:  4.40E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24017(1-methyl-5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro...)
Affinity DataIC50:  4.60E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM24007(1-benzyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50:  5.60E+3nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM23997(5'-phenyl-5-(trifluoromethoxy)-1,2-dihydro-3'H-spi...)
Affinity DataIC50:  7.20E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24020(5'-(4-methoxyphenyl)-1-methyl-1,2-dihydro-3'H-spir...)
Affinity DataIC50:  7.50E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM23996(5-ethyl-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,2...)
Affinity DataIC50:  9.60E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24009(5'-(4-methoxyphenyl)-5-methyl-1-(2-methylphenyl)-1...)
Affinity DataIC50:  1.05E+4nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM23995(5-methyl-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,...)
Affinity DataIC50:  1.11E+4nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24002(5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spiro[indole-...)
Affinity DataIC50:  1.34E+4nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM23994(5-bromo-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,2...)
Affinity DataIC50:  1.36E+4nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM24006(5'-(4-methoxyphenyl)-6-propyl-1,2-dihydro-3'H-spir...)
Affinity DataIC50: >2.20E+4nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM24009(5'-(4-methoxyphenyl)-5-methyl-1-(2-methylphenyl)-1...)
Affinity DataIC50: >2.20E+4nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24008(1-benzyl-5'-(4-methoxyphenyl)-5-methyl-1,2-dihydro...)
Affinity DataIC50: >2.20E+4nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24006(5'-(4-methoxyphenyl)-6-propyl-1,2-dihydro-3'H-spir...)
Affinity DataIC50: >2.20E+4nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24007(1-benzyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50: >2.20E+4nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM24008(1-benzyl-5'-(4-methoxyphenyl)-5-methyl-1,2-dihydro...)
Affinity DataIC50: >2.20E+4nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24014(1-methyl-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,...)
Affinity DataIC50:  2.41E+4nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM23992(5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,2'-[1,3,4...)
Affinity DataIC50:  2.42E+4nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM24007(1-benzyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM24009(5'-(4-methoxyphenyl)-5-methyl-1-(2-methylphenyl)-1...)
Affinity DataIC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM24008(1-benzyl-5'-(4-methoxyphenyl)-5-methyl-1,2-dihydro...)
Affinity DataIC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed