Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50021221
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222230BDBM50222230((E)-N-((1S,3R)-3-((4-(4-methoxyphenyl)piperidin-1-...)
Affinity DataIC50: 80nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222258BDBM50222258((E)-N-(3-((4-(4-methoxyphenyl)piperidin-1-yl)methy...)
Affinity DataIC50: 130nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222246BDBM50222246((E)-3-(3,4-dichlorophenyl)-N-(3-((4-(4-methoxyphen...)
Affinity DataIC50: 140nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222242BDBM50222242((E)-3-(3,5-difluorophenyl)-N-((1S,3R)-3-((4-(4-met...)
Affinity DataIC50: 160nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222237BDBM50222237((E)-3-(3,5-dichlorophenyl)-N-((1S,3R)-3-((4-(4-met...)
Affinity DataIC50: 160nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222231BDBM50222231((E)-3-(3,5-dichlorophenyl)-N-(3-((4-(4-methoxyphen...)
Affinity DataIC50: 180nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222240BDBM50222240((E)-3-(3,5-difluorophenyl)-N-(3-((4-(4-methoxyphen...)
Affinity DataIC50: 240nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222227BDBM50222227((E)-1-(4-((4-(4-chlorophenyl)piperidin-1-yl)methyl...)
Affinity DataIC50: 300nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222227BDBM50222227((E)-1-(4-((4-(4-chlorophenyl)piperidin-1-yl)methyl...)
Affinity DataIC50: 300nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222232BDBM50222232((E)-3-(3,4-dichlorophenyl)-1-(4-((4-(4-methoxyphen...)
Affinity DataIC50: 320nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222256BDBM50222256((E)-3-(3,4-dichlorophenyl)-1-(4-((4-(4-hydroxyphen...)
Affinity DataIC50: 510nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222244BDBM50222244((E)-3-(3,5-difluorophenyl)-N-(3-((4-(3,4-difluorop...)
Affinity DataIC50: 790nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222229BDBM50222229((E)-3-(3,4-dichlorophenyl)-1-(4-((4-(4-(dimethylam...)
Affinity DataIC50: 950nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222252BDBM50222252((E)-N-(5-(4-(4-chlorophenyl)piperidin-1-yl)pentyl)...)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222253BDBM50222253((E)-1-(4-((4-(4-chlorophenyl)piperidin-1-yl)methyl...)
Affinity DataIC50: 1.40E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222239BDBM50222239((E)-3-(3,4-dichlorophenyl)-N-(5-(4-(4-methoxypheny...)
Affinity DataIC50: 1.50E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222236BDBM50222236((E)-N-(5-(4-(4-chlorophenyl)piperidin-1-yl)pentyl)...)
Affinity DataIC50: 1.80E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222226BDBM50222226((E)-N-(4-(4-(4-chlorophenyl)piperidin-1-yl)butyl)-...)
Affinity DataIC50: 1.90E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222225BDBM50222225((E)-1-(4-((4-(4-chlorophenyl)piperidin-1-yl)methyl...)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222254BDBM50222254((E)-3-(4-fluorophenyl)-N-(5-(4-(4-methoxyphenyl)pi...)
Affinity DataIC50: 2.10E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222248BDBM50222248((E)-3-(3,4-dichlorophenyl)-1-(4-((4-p-tolylpiperid...)
Affinity DataIC50: 2.20E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222234BDBM50222234((E)-3-(4-fluorophenyl)-N-(4-(4-(4-methoxyphenyl)pi...)
Affinity DataIC50: 2.30E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222238BDBM50222238((E)-3-(3,4-dichlorophenyl)-N-(4-(4-(4-methoxypheny...)
Affinity DataIC50: 2.60E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222224BDBM50222224((E)-1-(4-(2-(4-(4-chlorophenyl)piperidin-1-yl)ethy...)
Affinity DataIC50: 2.90E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222250BDBM50222250((E)-N-(4-(4-(4-chlorophenyl)piperidin-1-yl)butyl)-...)
Affinity DataIC50: 2.90E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222245BDBM50222245((E)-N-(4-(4-(4-chlorophenyl)piperidin-1-yl)butyl)-...)
Affinity DataIC50: 3.10E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222257BDBM50222257((E)-N-(4-(4-(4-methoxyphenyl)piperidin-1-yl)butyl)...)
Affinity DataIC50: 3.40E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222243BDBM50222243((E)-3-(3,5-difluorophenyl)-N-(4-(4-(4-methoxypheny...)
Affinity DataIC50: 3.80E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222255BDBM50222255((E)-3-(3,4-dichlorophenyl)-1-(4-((4-(3-methoxyphen...)
Affinity DataIC50: 4.00E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222259BDBM50222259((E)-N-(4-(4-(4-chlorophenyl)piperidin-1-yl)butyl)-...)
Affinity DataIC50: 4.50E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222235BDBM50222235((E)-3-(4-bromophenyl)-1-(4-((4-(4-chlorophenyl)pip...)
Affinity DataIC50: 5.20E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222247BDBM50222247((E)-1-(4-((4-(4-chlorophenyl)piperidin-1-yl)methyl...)
Affinity DataIC50: 5.90E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222228BDBM50222228((E)-3-(3,5-dichlorophenyl)-N-((1R,3S)-3-((4-(4-met...)
Affinity DataIC50: 6.45E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222251BDBM50222251((E)-N-((1R,3S)-3-((4-(4-methoxyphenyl)piperidin-1-...)
Affinity DataIC50: 8.40E+3nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222249BDBM50222249((E)-3-(3,4-dichlorophenyl)-1-(4-((4-(2-methoxyphen...)
Affinity DataIC50: 1.11E+4nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222241BDBM50222241((E)-3-(3,5-difluorophenyl)-N-((1R,3S)-3-((4-(4-met...)
Affinity DataIC50: 1.20E+4nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222233BDBM50222233((E)-3-(3,4-dichlorophenyl)-N-(5-(4-(4-hydroxypheny...)
Affinity DataIC50: 1.26E+4nMAssay Description:Displacement of [125]MCP1 from human CCR2 receptor in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222227BDBM50222227((E)-1-(4-((4-(4-chlorophenyl)piperidin-1-yl)methyl...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222227BDBM50222227((E)-1-(4-((4-(4-chlorophenyl)piperidin-1-yl)methyl...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222227BDBM50222227((E)-1-(4-((4-(4-chlorophenyl)piperidin-1-yl)methyl...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222227BDBM50222227((E)-1-(4-((4-(4-chlorophenyl)piperidin-1-yl)methyl...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50222227BDBM50222227((E)-1-(4-((4-(4-chlorophenyl)piperidin-1-yl)methyl...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed