Compile Data Set for Download or QSAR
maximum 50k data
Found 29 Enz. Inhib. hit(s) with all data for entry = 2912
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25986(D3RKN_63 | N-(4-methanesulfonamidophenyl)-4-[2-met...)
Affinity DataKi:  40nM ΔG°:  -41.8kJ/mole IC50:  280nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25987(N-[(4-methanesulfonamidophenyl)methyl]-4-[2-methyl...)
Affinity DataKi:  40nM ΔG°:  -41.8kJ/mole IC50:  280nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25989(N-[(3-methoxyphenyl)methyl]-4-[2-methyl-5-(5-methy...)
Affinity DataKi:  60nM ΔG°:  -40.8kJ/mole IC50:  370nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25990(N-[(4-methoxyphenyl)methyl]-4-[2-methyl-5-(5-methy...)
Affinity DataKi:  80nM ΔG°:  -40.1kJ/mole IC50:  520nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25991(N-[(4-chlorophenyl)methyl]-4-[2-methyl-5-(5-methyl...)
Affinity DataKi:  100nM ΔG°:  -39.6kJ/mole IC50:  600nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25985(4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pheny...)
Affinity DataKi:  100nM ΔG°:  -39.6kJ/mole IC50:  600nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25988(N-benzyl-4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2...)
Affinity DataKi:  100nM ΔG°:  -39.6kJ/mole IC50:  610nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25992(4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pheny...)
Affinity DataKi:  140nM ΔG°:  -38.7kJ/mole IC50:  870nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25993(N-[(4-chlorophenyl)methyl]-N-methyl-4-[2-methyl-5-...)
Affinity DataKi:  140nM ΔG°:  -38.7kJ/mole IC50:  890nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM26005(N-(cyclopropylmethyl)-4-[2-methyl-5-(5-methyl-4H-1...)
Affinity DataKi:  220nM ΔG°:  -37.6kJ/mole IC50:  1.40E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25980(BMCL18324 Compound 3 | CHEMBL270164 | N-(3-cyanoph...)
Affinity DataKi:  240nM ΔG°:  -37.4kJ/mole IC50:  1.50E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25984(N-(2-methoxyphenyl)-4-[2-methyl-5-(5-methyl-1,3,4-...)
Affinity DataKi:  250nM ΔG°:  -37.3kJ/mole IC50:  1.60E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25983(D3RKN_86 | N-(4-methoxyphenyl)-4-[2-methyl-5-(5-me...)
Affinity DataKi:  360nM ΔG°:  -36.4kJ/mole IC50:  2.30E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25981(BMCL18324 Compound 17 | CHEMBL273158 | D3RKN_78 | ...)
Affinity DataKi:  480nM ΔG°:  -35.7kJ/mole IC50:  3.00E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25982(4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pheny...)
Affinity DataKi:  490nM ΔG°:  -35.7kJ/mole IC50:  3.10E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25996(N-(3-hydroxypropyl)-4-[2-methyl-5-(5-methyl-1,3,4-...)
Affinity DataKi:  1.10E+3nM ΔG°:  -33.7kJ/mole IC50:  7.10E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM26001(N-(cyclopropylmethyl)-4-[2-methyl-5-(5-propyl-1,3,...)
Affinity DataKi:  1.50E+3nM ΔG°:  -32.9kJ/mole IC50:  9.70E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25979(BMCL18324 Compound 1 | N-[4-methoxy-3-(4-methylpip...)
Affinity DataKi:  1.60E+3nM ΔG°:  -32.7kJ/mole IC50:  1.00E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25998(2-methyl-5-{4-methyl-3-[4-(piperidin-1-ylcarbonyl)...)
Affinity DataKi:  1.60E+3nM ΔG°:  -32.7kJ/mole IC50:  1.00E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM26000(N-(cyclopropylmethyl)-4-[5-(5-ethyl-1,3,4-oxadiazo...)
Affinity DataKi:  1.60E+3nM ΔG°:  -32.7kJ/mole IC50:  1.00E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM26004(N-(cyclopropylmethyl)-4-[5-(1H-imidazol-2-yl)-2-me...)
Affinity DataKi:  1.70E+3nM ΔG°:  -32.6kJ/mole IC50:  1.10E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25994(N-(3-cyanophenyl)-N-methyl-4-[2-methyl-5-(5-methyl...)
Affinity DataKi:  1.90E+3nM ΔG°:  -32.3kJ/mole IC50:  1.20E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM26003(N-(cyclopropylmethyl)-4-[2-methyl-5-(5-methyl-1,2,...)
Affinity DataKi:  2.00E+3nM ΔG°:  -32.2kJ/mole IC50:  1.40E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25997(4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pheny...)
Affinity DataKi: >2.50E+3nM ΔG°: >-31.7kJ/mole IC50: >1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM26002(4-[5-(5-butyl-1,3,4-oxadiazol-2-yl)-2-methylphenyl...)
Affinity DataKi: >2.50E+3nM ΔG°: >-31.7kJ/mole IC50: >1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25995(4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pheny...)
Affinity DataKi: >2.50E+3nM ΔG°: >-31.7kJ/mole IC50: >1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM26007(N-(cyclopropylmethyl)-3-methyl-4-[3-(5-methyl-1,3,...)
Affinity DataKi: >2.50E+3nM ΔG°: >-31.7kJ/mole IC50: >1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM26006(N-(cyclopropylmethyl)-4-[3-(5-methyl-1,3,4-oxadiaz...)
Affinity DataKi: >2.50E+3nM ΔG°: >-31.7kJ/mole IC50: >1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25999(N-(cyclopropylmethyl)-4-[2-methyl-5-(1,3,4-oxadiaz...)
Affinity DataKi: >2.50E+3nM ΔG°: >-31.7kJ/mole IC50: >1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed