Compile Data Set for Download or QSAR
Report error Found 46 Enz. Inhib. hit(s) with all data for entry = 50021997
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230243(3-((1-((3S,4R)-1-tert-butyl-3-(2,4-difluorophenyl)...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230271(N-((S)-1-(2-(4-((2R,3R)-3-(4-chlorophenyl)-tetrahy...)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230243(3-((1-((3S,4R)-1-tert-butyl-3-(2,4-difluorophenyl)...)
Affinity DataIC50: 14nMAssay Description:Binding affinity at MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50191011((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluo...)
Affinity DataKi:  26nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230260(N-((S)-1-(2-(4-((3S,4S)-3-(4-chlorophenyl)-tetrahy...)
Affinity DataKi:  28nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230256(N-((S)-1-(2-(4-((3S,4R)-3-(4-chlorophenyl)-tetrahy...)
Affinity DataKi:  30nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50191017((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluo...)
Affinity DataKi:  31nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230263(N-[(S)-1-(2-{4-[(3R,4R)-4-(4-chloro-phenyl)-1,1-di...)
Affinity DataKi:  37nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230241({4-[2-((S)-1-amino-3-methyl-butyl)-4-trifluorometh...)
Affinity DataKi:  38nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230259(N-((S)-1-(2-(4-(3-(4-chlorophenyl)-tetrahydrofuran...)
Affinity DataKi:  40nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230242(N-((S)-1-(2-(4-((2S,3R)-3-(4-chlorophenyl)-tetrahy...)
Affinity DataKi:  43nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230245(N-((S)-1-(2-(4-(3-(4-chlorophenyl)-tetrahydrofuran...)
Affinity DataKi:  71nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189237((1S)-[2-{4-[3-(2,4-dichlorophenyl)propionyl]-1-pip...)
Affinity DataKi:  74nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230246(N-((S)-1-(5-chloro-2-(4-((2S,3S)-2-(4-chlorophenyl...)
Affinity DataKi:  74nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230276(N-((S)-1-(5-chloro-2-(4-((2S,3R)-2-(4-chlorophenyl...)
Affinity DataKi:  87nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230272((R)-N-[(S)-1-(2-{4-[(3S,4S)-4-(4-chloro-phenyl)-1,...)
Affinity DataKi:  100nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230254(3-amino-N-((S)-1-(2-(4-(2-(4-chlorophenyl)-5-oxo-t...)
Affinity DataKi:  110nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230244({4-[2-((S)-1-amino-3-methyl-butyl)-4-trifluorometh...)
Affinity DataKi:  120nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230253(N-((S)-1-(2-(4-((2S,3R)-2-(4-chlorophenyl)-tetrahy...)
Affinity DataKi:  120nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230278(N-((S)-1-(2-(4-((3S,4S)-3-(4-chlorophenyl)-tetrahy...)
Affinity DataKi:  130nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230255((R)-2-amino-N-((S)-1-(2-(4-((3S,4S)-3-(4-chlorophe...)
Affinity DataKi:  130nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50191016((S)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluo...)
Affinity DataKi:  140nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230269(N-((S)-1-(2-(4-((3S,4S)-3-(4-chlorophenyl)-tetrahy...)
Affinity DataKi:  170nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230252([(3S,4S)-4-(4-chloro-phenyl)-1,1-dioxo-tetrahydro-...)
Affinity DataKi:  170nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230257(3-amino-N-((S)-1-(2-(4-(4-(4-chlorophenyl)-2-oxo-t...)
Affinity DataKi:  180nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230250(N-[(S)-1-(2-{4-[(3S,4S)-4-(4-chloro-phenyl)-1,1-di...)
Affinity DataKi:  180nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230258(N-[(S)-1-(2-{4-[(3S,4S)-4-(4-chloro-phenyl)-1,1-di...)
Affinity DataKi:  190nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230265(N-((S)-1-(2-(4-((2S,3S)-2-(4-chlorophenyl)-tetrahy...)
Affinity DataKi:  200nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230262(N-[(S)-1-(2-{4-[(3S,4S)-4-(4-chloro-phenyl)-1-oxo-...)
Affinity DataKi:  230nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230261(N-((S)-1-(2-(4-((3S,4S)-3-(4-chlorophenyl)-tetrahy...)
Affinity DataKi:  250nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230249(3-(1-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  260nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230248((4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorometh...)
Affinity DataKi:  280nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230268((4-(2-((S)-1-amino-3-methylbutyl)-4-chlorophenyl)p...)
Affinity DataKi:  280nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230270((4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorometh...)
Affinity DataKi:  280nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230240(N-((S)-1-(2-(4-(4-(4-chlorophenyl)-2-oxo-tetrahydr...)
Affinity DataKi:  290nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230264((4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorometh...)
Affinity DataKi:  330nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230266(N-[(S)-1-(2-{4-[(3S,4S)-4-(4-chloro-phenyl)-1,1-di...)
Affinity DataKi:  380nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230247((4-(2-((S)-1-amino-2-methylpropyl)-4-methylphenyl)...)
Affinity DataKi:  410nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230251(N-((S)-1-(2-(4-((2S,3R)-2-(4-chlorophenyl)-tetrahy...)
Affinity DataKi:  480nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230271(N-((S)-1-(2-(4-((2R,3R)-3-(4-chlorophenyl)-tetrahy...)
Affinity DataIC50: 530nMAssay Description:Antagonist activity at human MC4R assessed as inhibition of alpha MSH-stimulated cAMP release by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230274((4-(2-((S)-1-amino-2-methylpropyl)-4-methylphenyl)...)
Affinity DataKi:  590nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230241({4-[2-((S)-1-amino-3-methyl-butyl)-4-trifluorometh...)
Affinity DataIC50: 690nMAssay Description:Antagonist activity at human MC4R assessed as inhibition of alpha MSH-stimulated cAMP release by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230277((4-(2-((S)-1-amino-2-methylpropyl)-6-fluorophenyl)...)
Affinity DataKi:  790nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230273((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  810nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230275((4-(2-((S)-1-amino-2-methylpropyl)-6-fluorophenyl)...)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50230267((4-(2-((S)-1-amino-2-methylpropyl)-6-fluorophenyl)...)
Affinity DataKi:  2.10E+3nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed