Compile Data Set for Download or QSAR
maximum 50k data
Found 75 Enz. Inhib. hit(s) with all data for entry = 2876
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25680(4-[(5-bromo-1,3-thiazol-2-yl)amino]benzoic acid | ...)
Affinity DataIC50:  79nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25683(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(2-methoxyet...)
Affinity DataIC50:  97nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25681(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzam...)
Affinity DataIC50:  140nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25684(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(1-methoxypr...)
Affinity DataIC50:  330nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25678(N-{4-[(5-bromo-1,3-thiazol-2-yl)amino]phenyl}aceta...)
Affinity DataIC50:  360nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Novartis

LigandPNGBDBM25658(5-bromo-N-(4-fluorophenyl)-1,3-thiazol-2-amine | a...)
Affinity DataIC50:  370nMAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) in the SelectScreen Kinase Profiling Service...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25658(5-bromo-N-(4-fluorophenyl)-1,3-thiazol-2-amine | a...)
Affinity DataIC50:  400nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Novartis

LigandPNGBDBM25681(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzam...)
Affinity DataIC50:  440nMAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) in the SelectScreen Kinase Profiling Service...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25697(3-[(5-bromo-1,3-thiazol-2-yl)amino]benzoic acid | ...)
Affinity DataIC50:  440nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25694(5-bromo-N-[3-(methylsulfanyl)phenyl]-1,3-thiazol-2...)
Affinity DataIC50:  500nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25660(N-(4-fluorophenyl)-5-iodo-1,3-thiazol-2-amine | am...)
Affinity DataIC50:  500nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25669(4-[(5-bromo-1,3-thiazol-2-yl)amino]phenol | aminot...)
Affinity DataIC50:  510nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25676(1-N-(5-bromo-1,3-thiazol-2-yl)benzene-1,4-diamine ...)
Affinity DataIC50:  600nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25699(3-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzam...)
Affinity DataIC50:  740nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25721(4-({6-[(5-cyano-1,3-thiazol-2-yl)amino]pyridin-3-y...)
Affinity DataIC50:  880nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25673(5-bromo-N-[4-(pyridin-4-yloxy)phenyl]-1,3-thiazol-...)
Affinity DataIC50:  900nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25693(5-bromo-N-(3-methoxyphenyl)-1,3-thiazol-2-amine | ...)
Affinity DataIC50:  900nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Novartis

LigandPNGBDBM25680(4-[(5-bromo-1,3-thiazol-2-yl)amino]benzoic acid | ...)
Affinity DataIC50:  960nMAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) in the SelectScreen Kinase Profiling Service...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25685(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(2-methoxyet...)
Affinity DataIC50:  980nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25662(5-bromo-N-phenyl-1,3-thiazol-2-amine | aminothiazo...)
Affinity DataIC50:  1.10E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25657(5-chloro-N-(4-fluorophenyl)-1,3-thiazol-2-amine | ...)
Affinity DataIC50:  1.10E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25691(5-bromo-N-(3-methylphenyl)-1,3-thiazol-2-amine | a...)
Affinity DataIC50:  1.10E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25698(3-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(2-methoxyet...)
Affinity DataIC50:  1.22E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25720(2-{[5-(morpholin-4-ylmethyl)pyridin-2-yl]amino}-1,...)
Affinity DataIC50:  1.40E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25672(5-bromo-N-(4-phenoxyphenyl)-1,3-thiazol-2-amine | ...)
Affinity DataIC50:  1.40E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25682(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(2-hydroxyet...)
Affinity DataIC50:  1.48E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25695(3-[(5-bromo-1,3-thiazol-2-yl)amino]benzonitrile | ...)
Affinity DataIC50:  1.50E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25674(1-{4-[(5-bromo-1,3-thiazol-2-yl)amino]phenyl}ethan...)
Affinity DataIC50:  1.70E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25670(5-bromo-N-(4-methoxyphenyl)-1,3-thiazol-2-amine | ...)
Affinity DataIC50:  1.70E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM5359(5-bromo-N-(pyridin-2-yl)-1,3-thiazol-2-amine | ACS...)
Affinity DataIC50:  2.00E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25668(4-[(5-bromo-1,3-thiazol-2-yl)amino]benzonitrile | ...)
Affinity DataIC50:  2.10E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25696(aminothiazole analogue, 40 | ethyl 3-[(5-bromo-1,3...)
Affinity DataIC50:  2.25E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25688(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-[2-(morpholi...)
Affinity DataIC50:  2.30E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25667(5-bromo-N-[4-(trifluoromethyl)phenyl]-1,3-thiazol-...)
Affinity DataIC50:  2.40E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM5362(2-(pyridin-2-ylamino)-1,3-thiazole-5-carbonitrile ...)
Affinity DataIC50:  2.50E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25703(5-bromo-N-(2-methoxyphenyl)-1,3-thiazol-2-amine | ...)
Affinity DataIC50:  2.70E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25666(5-bromo-N-(4-methylphenyl)-1,3-thiazol-2-amine | a...)
Affinity DataIC50:  2.84E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25664(5-bromo-N-(4-bromophenyl)-1,3-thiazol-2-amine | am...)
Affinity DataIC50:  2.90E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25701(5-bromo-N-(2-methylphenyl)-1,3-thiazol-2-amine | a...)
Affinity DataIC50:  3.00E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25663(5-bromo-N-(4-chlorophenyl)-1,3-thiazol-2-amine | a...)
Affinity DataIC50:  3.00E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25717(5-bromo-N-(pyridin-3-yl)-1,3-thiazol-2-amine | ami...)
Affinity DataIC50:  3.60E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25722(2-({5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl...)
Affinity DataIC50:  3.80E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Novartis

LigandPNGBDBM25681(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzam...)
Affinity DataIC50:  4.27E+3nMAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) in the SelectScreen Kinase Profiling Service...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25723(2-({5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}...)
Affinity DataIC50:  4.40E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25687(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-[2-(diethyla...)
Affinity DataIC50:  4.52E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25715(5-bromo-N-(naphthalen-1-yl)-1,3-thiazol-2-amine | ...)
Affinity DataIC50:  5.00E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25686(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-[2-(dimethyl...)
Affinity DataIC50:  5.25E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25689(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-[2-(pyrrolid...)
Affinity DataIC50:  5.32E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25724(2-[(5-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}py...)
Affinity DataIC50:  5.40E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25712(N-(5-bromo-1,3-thiazol-2-yl)benzamide | aminothiaz...)
Affinity DataIC50:  5.50E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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