Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 3286
TargetGenome polyprotein(HCV)
Anadys Pharmaceuticals

LigandPNGBDBM30415(pyrrolo[1,2-b]pyridazin-2-one analog., 3h)
Affinity DataIC50: 10nM EC50:  5nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Anadys Pharmaceuticals

LigandPNGBDBM30407(BMCL185002 Compound 1 | 5-hydroxy- 3(2H)-pyridazin...)
Affinity DataIC50: 10nM EC50:  5nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein(HCV)
Anadys Pharmaceuticals

LigandPNGBDBM30410(pyrrolo[1,2-b]pyridazin-2-one analog., 3c)
Affinity DataIC50: 10nM EC50:  8.5nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein(HCV)
Anadys Pharmaceuticals

LigandPNGBDBM30418(BMCL19451 Compound 2 | BMCL185002 Compound 3a | py...)
Affinity DataIC50: 10nM EC50:  12nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Anadys Pharmaceuticals

LigandPNGBDBM30411(pyrrolo[1,2-b]pyridazin-2-one analog., 3d)
Affinity DataIC50: 27nM EC50:  19nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Anadys Pharmaceuticals

LigandPNGBDBM30419(pyrrolo[1,2-b]pyridazin-2-one analog., 3l)
Affinity DataIC50: 25nM EC50:  22nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Anadys Pharmaceuticals

LigandPNGBDBM30416(pyrrolo[1,2-b]pyridazin-2-one analog., 3i)
Affinity DataIC50: 60nM EC50:  120nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Anadys Pharmaceuticals

LigandPNGBDBM30414(pyrrolo[1,2-b]pyridazin-2-one analog., 3g)
Affinity DataIC50: 160nM EC50:  96nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Anadys Pharmaceuticals

LigandPNGBDBM30413(pyrrolo[1,2-b]pyridazin-2-one analog., 3f)
Affinity DataIC50: 110nM EC50:  190nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Anadys Pharmaceuticals

LigandPNGBDBM30420(pyrrolo[1,2-b]pyridazin-2-one analog., 3m)
Affinity DataIC50: 130nM EC50:  330nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Anadys Pharmaceuticals

LigandPNGBDBM30421(Racemic | pyrrolo[1,2-b]pyridazin-2-one analog., 3...)
Affinity DataIC50: 130nM EC50:  380nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Anadys Pharmaceuticals

LigandPNGBDBM30406(CHEMBL176058 | benzo[1,2,4]thiadiazine-1,1-dioxide...)
Affinity DataIC50: 200nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Anadys Pharmaceuticals

LigandPNGBDBM30412(pyrrolo[1,2-b]pyridazin-2-one analog., 3e)
Affinity DataIC50: 320nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Anadys Pharmaceuticals

LigandPNGBDBM30417(pyrrolo[1,2-b]pyridazin-2-one analog., 3j)
Affinity DataIC50: 850nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Anadys Pharmaceuticals

LigandPNGBDBM30408(pyrrolo[1,2-b]pyridazin-2-one analog., 3a)
Affinity DataIC50: 980nM EC50:  5.30E+3nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Anadys Pharmaceuticals

LigandPNGBDBM30409(pyrrolo[1,2-b]pyridazin-2-one analog., 3b)
Affinity DataIC50: 2.20E+3nM EC50:  1.70E+4nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed