Compile Data Set for Download or QSAR
Report error Found 50 Enz. Inhib. hit(s) with all data for entry = 50026374
LigandPNGBDBM50243125(N3-(6-acetamidopyridin-3-yl)-4-methyl-N1-(3-(trifl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM26365(CHEMBL272902 | 3-N-(2-aminopyrimidin-5-yl)-4-methy...)
Affinity DataIC50: 5nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243076(N3-(6-aminopyridin-3-yl)-4-methyl-N1-(3-(trifluoro...)
Affinity DataIC50: 7nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243181(N3-(6-aminopyridin-3-yl)-N1-(3-cyclohexylpropyl)-4...)
Affinity DataIC50: 9nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM26373(CHEMBL259247 | 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[...)
Affinity DataIC50: 14nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243075(4-methyl-N3-(pyridin-3-yl)-N1-(3-(trifluoromethyl)...)
Affinity DataIC50: 18nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50243076(N3-(6-aminopyridin-3-yl)-4-methyl-N1-(3-(trifluoro...)
Affinity DataIC50: 24nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243180(N3-(6-aminopyridin-3-yl)-N1-(2-cyclohexylethyl)-4-...)
Affinity DataIC50: 35nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50242924(4-methyl-N3-(pyrimidin-5-yl)-N1-(3-(trifluoromethy...)
Affinity DataIC50: 37nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50243125(N3-(6-acetamidopyridin-3-yl)-4-methyl-N1-(3-(trifl...)
Affinity DataIC50: 45nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 52nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50243181(N3-(6-aminopyridin-3-yl)-N1-(3-cyclohexylpropyl)-4...)
Affinity DataIC50: 57.8nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243124(N3-(2-acetamidopyrimidin-5-yl)-4-methyl-N1-(3-(tri...)
Affinity DataIC50: 58nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243182(N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-...)
Affinity DataIC50: 77nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM26365(CHEMBL272902 | 3-N-(2-aminopyrimidin-5-yl)-4-methy...)
Affinity DataIC50: 87nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243074(N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoy...)
Affinity DataIC50: 108nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 110nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243125(N3-(6-acetamidopyridin-3-yl)-4-methyl-N1-(3-(trifl...)
Affinity DataIC50: 114nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243126(N3-(6-aminopyridin-3-yl)-4-methyl-N1-(4-(trifluoro...)
Affinity DataIC50: 120nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50243180(N3-(6-aminopyridin-3-yl)-N1-(2-cyclohexylethyl)-4-...)
Affinity DataIC50: 181nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM26373(CHEMBL259247 | 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[...)
Affinity DataIC50: 200nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM26365(CHEMBL272902 | 3-N-(2-aminopyrimidin-5-yl)-4-methy...)
Affinity DataIC50: 205nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50243075(4-methyl-N3-(pyridin-3-yl)-N1-(3-(trifluoromethyl)...)
Affinity DataIC50: 219nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM26373(CHEMBL259247 | 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[...)
Affinity DataIC50: 240nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM26373(CHEMBL259247 | 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[...)
Affinity DataIC50: 240nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM26373(CHEMBL259247 | 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[...)
Affinity DataIC50: 240nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243075(4-methyl-N3-(pyridin-3-yl)-N1-(3-(trifluoromethyl)...)
Affinity DataIC50: 294nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 320nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50243074(N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoy...)
Affinity DataIC50: 455nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243076(N3-(6-aminopyridin-3-yl)-4-methyl-N1-(3-(trifluoro...)
Affinity DataIC50: 470nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50242924(4-methyl-N3-(pyrimidin-5-yl)-N1-(3-(trifluoromethy...)
Affinity DataIC50: 546nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243124(N3-(2-acetamidopyrimidin-5-yl)-4-methyl-N1-(3-(tri...)
Affinity DataIC50: 748nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50243182(N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-...)
Affinity DataIC50: 998nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243179(N3-(6-aminopyridin-3-yl)-N1-(cyclohexylmethyl)-4-m...)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50242924(4-methyl-N3-(pyrimidin-5-yl)-N1-(3-(trifluoromethy...)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50243124(N3-(2-acetamidopyrimidin-5-yl)-4-methyl-N1-(3-(tri...)
Affinity DataIC50: 1.73E+3nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50242924(4-methyl-N3-(pyrimidin-5-yl)-N1-(3-(trifluoromethy...)
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50243074(N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoy...)
Affinity DataIC50: 2.76E+3nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50242924(4-methyl-N3-(pyrimidin-5-yl)-N1-(3-(trifluoromethy...)
Affinity DataIC50: 3.53E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243183(N3-(6-aminopyridin-3-yl)-4-methyl-N1-(2-(pyrrolidi...)
Affinity DataIC50: 3.64E+3nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243074(N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoy...)
Affinity DataIC50: 3.76E+3nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243127(N3-(6-aminopyridin-3-yl)-N1-cyclohexyl-4-methyliso...)
Affinity DataIC50: 4.47E+3nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243074(N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoy...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243126(N3-(6-aminopyridin-3-yl)-4-methyl-N1-(4-(trifluoro...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243181(N3-(6-aminopyridin-3-yl)-N1-(3-cyclohexylpropyl)-4...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM26373(CHEMBL259247 | 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[...)
Affinity DataIC50: 8.33E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 1.37E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243180(N3-(6-aminopyridin-3-yl)-N1-(2-cyclohexylethyl)-4-...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243182(N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)