Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50026481
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251959BDBM50251959(2-(2-(2-(4-tert-butylbenzylsulfonyl)acetamido)-3-h...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251958BDBM50251958(2-(2-(2-(benzylsulfonyl)acetamido)-3-hydroxy-2,3-d...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251957BDBM50251957({2-[2-(Biphenyl-4-sulfonyl)-acetylimino]-3-hydroxy...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252002BDBM50252002(2-(2-(2-(4-tert-butylphenylsulfonyl)acetamido)-3-h...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251908BDBM50251908(2-(3-hydroxy-2-(2-(naphthalen-2-ylsulfonyl)acetami...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251907BDBM50251907(2-(2-(2-(4-chlorophenylsulfonyl)acetamido)-3-hydro...)
Affinity DataIC50: 33nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252001BDBM50252001(2-(3-hydroxy-2-(2-tosylacetamido)-2,3-dihydrothiaz...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251905BDBM50251905(2-(2-(2-(2-chlorophenylsulfonyl)acetamido)-3-hydro...)
Affinity DataIC50: 72nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251900BDBM50251900(2-(3-hydroxy-2-(2-(phenylsulfonyl)acetamido)-2,3-d...)
Affinity DataIC50: 72nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251906BDBM50251906(2-(2-(2-(3-chlorophenylsulfonyl)acetamido)-3-hydro...)
Affinity DataIC50: 98nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251954BDBM50251954(2-(3-hydroxy-5-methyl-2-(2-(phenylsulfonyl)acetami...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251955BDBM50251955(3-(3-hydroxy-2-(2-(phenylsulfonyl)acetamido)-2,3-d...)
Affinity DataIC50: 410nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50252000BDBM50252000(2-(3-hydroxy-2-(2-(methylsulfonyl)acetamido)-2,3-d...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251904BDBM50251904(2-(3-hydroxy-2-(2-(phenylsulfonyl)acetamido)-2,3-d...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251998BDBM50251998(2-(3-hydroxy-2-(2-(phenylamino)acetamido)-2,3-dihy...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251956BDBM50251956(2-(3-hydroxy-2-(2-(phenylthio)acetamido)-2,3-dihyd...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251997BDBM50251997(2-(3-hydroxy-2-(2-phenoxyacetamido)-2,3-dihydrothi...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251903BDBM50251903(2-(2-(2-(phenylsulfonyl)acetamido)thiazol-4-yl)ace...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251901BDBM50251901(ethyl 2-(2-(2-(phenylsulfonyl)acetamido)thiazol-4-...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251902BDBM50251902(ethyl 2-(3-hydroxy-2-(2-(phenylsulfonyl)acetamido)...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251999BDBM50251999(2-(3-hydroxy-2-(3-phenylpropanamido)-2,3-dihydroth...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251953BDBM50251953(2-(3-hydroxy-2-(2-(phenylsulfonyl)acetamido)-2,3-d...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human PHD2 assessed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed