Compile Data Set for Download or QSAR
Report error Found 63 Enz. Inhib. hit(s) with all data for entry = 2753
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24206BDBM24206(2-{4-[2-(azepan-1-yl)ethoxy]phenoxy}-1,3-benzoxazo...)
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24216BDBM24216(1-{2-[4-(1,3-benzoxazol-2-yloxy)phenoxy]ethyl}-4-p...)
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24199BDBM24199(2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenoxy}-1,3-benzo...)
Affinity DataIC50: 7nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24224BDBM24224(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}pip...)
Affinity DataIC50: 8nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24238BDBM24238(N-(1-{[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl}p...)
Affinity DataIC50: 8nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24212BDBM24212(1-{2-[4-(1,3-benzoxazol-2-yloxy)phenoxy]ethyl}pipe...)
Affinity DataIC50: 9nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24235BDBM24235(3-(1-{[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl}p...)
Affinity DataIC50: 10nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24203BDBM24203(2-{4-[2-(piperidin-1-yl)ethoxy]phenoxy}-1,3-benzox...)
Affinity DataIC50: 11nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24222BDBM24222(3-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...)
Affinity DataIC50: 11nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24239BDBM24239(1-{[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl}pipe...)
Affinity DataIC50: 11nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24234BDBM24234(1-(1-{[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl}p...)
Affinity DataIC50: 12nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24236BDBM24236(N-(1-{[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl}p...)
Affinity DataIC50: 12nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24215BDBM24215((1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}p...)
Affinity DataIC50: 13nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24218BDBM24218(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}pi...)
Affinity DataIC50: 13nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24227BDBM24227(1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}...)
Affinity DataIC50: 13nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24214BDBM24214((1-{2-[4-(1,3-benzoxazol-2-yloxy)phenoxy]ethyl}pip...)
Affinity DataIC50: 14nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24201BDBM24201(2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenoxy}-1,3-benzo...)
Affinity DataIC50: 14nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24220BDBM24220(1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...)
Affinity DataIC50: 16nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24233BDBM24233(1-{[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl}pipe...)
Affinity DataIC50: 17nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24223BDBM24223(2-{4-[2-(piperidin-1-yl)ethyl]phenoxy}-1,3-benzoth...)
Affinity DataIC50: 17nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24237BDBM24237([(1-{[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl}pi...)
Affinity DataIC50: 21nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24240BDBM24240(2-{4-[3-(piperidin-1-yl)propoxy]phenoxy}-1,3-benzo...)
Affinity DataIC50: 27nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24225BDBM24225(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}pip...)
Affinity DataIC50: 28nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24228BDBM24228(3-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}...)
Affinity DataIC50: 29nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24213BDBM24213(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}pi...)
Affinity DataIC50: 31nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24232BDBM24232(1-{[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl}pipe...)
Affinity DataIC50: 34nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24229BDBM24229(N-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}...)
Affinity DataIC50: 35nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24230BDBM24230([(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}p...)
Affinity DataIC50: 50nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24204BDBM24204(2-{4-[2-(piperidin-1-yl)ethoxy]phenoxy}-1,3-benzot...)
Affinity DataIC50: 54nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24209BDBM24209(2-{4-[2-(morpholin-4-yl)ethoxy]phenoxy}-1,3-benzox...)
Affinity DataIC50: 58nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24231BDBM24231(2-[4-(piperidin-1-ylmethyl)phenoxy]-1,3-benzothiaz...)
Affinity DataIC50: 59nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24217BDBM24217(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}-4...)
Affinity DataIC50: 66nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24219BDBM24219(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}pi...)
Affinity DataIC50: 66nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24207BDBM24207(2-{4-[2-(azepan-1-yl)ethoxy]phenoxy}-1,3-benzothia...)
Affinity DataIC50: 66nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24221BDBM24221(1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...)
Affinity DataIC50: 70nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24202BDBM24202(2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenoxy}-1H-1,3-be...)
Affinity DataIC50: 84nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24241BDBM24241(2-{4-[3-(piperidin-1-yl)propoxy]phenoxy}-1,3-benzo...)
Affinity DataIC50: 87nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24205BDBM24205(2-{4-[2-(piperidin-1-yl)ethoxy]phenoxy}-1H-1,3-ben...)
Affinity DataIC50: 110nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24208BDBM24208(2-{4-[2-(azepan-1-yl)ethoxy]phenoxy}-1H-1,3-benzod...)
Affinity DataIC50: 140nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24210BDBM24210(4-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}mo...)
Affinity DataIC50: 350nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24228BDBM24228(3-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}...)
Affinity DataIC50: 500nMAssay Description:Compounds were assessed for their ability to displace [3H]astemizole using membranes from HEK-293 cells expressing the hERG K+ channel.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24242BDBM24242(2-{4-[3-(piperidin-1-yl)propoxy]phenoxy}-1H-1,3-be...)
Affinity DataIC50: 710nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24203BDBM24203(2-{4-[2-(piperidin-1-yl)ethoxy]phenoxy}-1,3-benzox...)
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Compounds were assessed for their ability to displace [3H]astemizole using membranes from HEK-293 cells expressing the hERG K+ channel.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24227BDBM24227(1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compounds were assessed for their ability to displace [3H]astemizole using membranes from HEK-293 cells expressing the hERG K+ channel.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24221BDBM24221(1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...)
Affinity DataIC50: 1.80E+3nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24223BDBM24223(2-{4-[2-(piperidin-1-yl)ethyl]phenoxy}-1,3-benzoth...)
Affinity DataIC50: 2.00E+3nMpH: 7.4 T: 2°CAssay Description:Compounds were assessed for their ability to displace [3H]astemizole using membranes from HEK-293 cells expressing the hERG K+ channel.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24222BDBM24222(3-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...)
Affinity DataIC50: 2.70E+3nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24220BDBM24220(1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...)
Affinity DataIC50: 2.70E+3nMT: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24211BDBM24211(4-{2-[4-(1H-1,3-benzodiazol-2-yloxy)phenoxy]ethyl}...)
Affinity DataIC50: 3.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 24224BDBM24224(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}pip...)
Affinity DataIC50: 3.00E+3nMpH: 7.4 T: 2°CAssay Description:Compounds were assessed for their ability to displace [3H]astemizole using membranes from HEK-293 cells expressing the hERG K+ channel.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
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