Compile Data Set for Download or QSAR
maximum 50k data
Found 46 Enz. Inhib. hit(s) with all data for entry = 50027035
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264866(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264865((4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-yl...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264773(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265350(4-(4'-chlorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264739(4-(3'-chlorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264866(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50:  130nMAssay Description:Inhibition of COT (unknown origin) by cell-based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265353(4-(4'-methoxybiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264738(4-(2'-chlorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM28042(5-[4-(4-phenylphenoxy)thieno[2,3-c]pyridin-2-yl]-1...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264740(4-(4'-fluorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50:  170nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264741(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50:  230nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265352(4-(3'-methoxybiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl...)
Affinity DataIC50:  240nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264742(2-(2H-tetrazol-5-yl)-4-(4'-(trifluoromethyl)biphen...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265351(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50:  310nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265349(4-(2'-methoxybiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265275(4-(4-iodophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3-c...)
Affinity DataIC50:  410nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265276(CHEMBL498592 | N-hydroxy-4-(4-iodophenoxy)thieno[2...)
Affinity DataIC50:  540nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264742(2-(2H-tetrazol-5-yl)-4-(4'-(trifluoromethyl)biphen...)
Affinity DataIC50:  560nMAssay Description:Inhibition of COT (unknown origin) by cell-based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265312(4-(4-tert-butylphenoxy)-2-(2H-tetrazol-5-yl)thieno...)
Affinity DataIC50:  610nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265311(4-(4-chlorophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3...)
Affinity DataIC50:  710nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM28045(4-(4-iodophenoxy)thieno[2,3-c]pyridine-2-carboxyli...)
Affinity DataIC50:  940nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265242(3-(4-(4-iodophenoxy)thieno[2,3-c]pyridin-2-yl)-1,2...)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264741(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of MEK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264738(4-(2'-chlorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of MEK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265310(4-(4-bromophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3-...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265279(4-(biphenyl-3-yloxy)-2-(2H-tetrazol-5-yl)thieno[2,...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264742(2-(2H-tetrazol-5-yl)-4-(4'-(trifluoromethyl)biphen...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of MEK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264739(4-(3'-chlorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of MEK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265350(4-(4'-chlorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of COT (unknown origin) by cell-based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265277(4-phenoxy-2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265350(4-(4'-chlorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of MEK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM28042(5-[4-(4-phenylphenoxy)thieno[2,3-c]pyridin-2-yl]-1...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of COT (unknown origin) by cell-based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264740(4-(4'-fluorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of COT (unknown origin) by cell-based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265309(2-(2H-tetrazol-5-yl)-4-(p-tolyloxy)thieno[2,3-c]py...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264740(4-(4'-fluorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of MEK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM28042(5-[4-(4-phenylphenoxy)thieno[2,3-c]pyridin-2-yl]-1...)
Affinity DataIC50:  9.70E+3nMAssay Description:Inhibition of MEK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264865((4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-yl...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of MEK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265278(4-(biphenyl-2-yloxy)-2-(2H-tetrazol-5-yl)thieno[2,...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264866(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of MEK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265351(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50:  2.12E+4nMAssay Description:Inhibition of MEK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265349(4-(2'-methoxybiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl...)
Affinity DataIC50:  2.18E+4nMAssay Description:Inhibition of MEK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265352(4-(3'-methoxybiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of MEK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264773(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibition of MEK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265353(4-(4'-methoxybiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl...)
Affinity DataIC50:  4.90E+4nMAssay Description:Inhibition of MEK1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265240(4-(4-iodophenoxy)thieno[2,3-c]pyridin-2-amine | CH...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265241(CHEMBL496947 | N-(4-(4-iodophenoxy)thieno[2,3-c]py...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed