Compile Data Set for Download or QSAR
Report error Found 46 Enz. Inhib. hit(s) with all data for entry = 50027035
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264866BDBM50264866(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264865BDBM50264865((4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-yl...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264773BDBM50264773(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265350BDBM50265350(4-(4'-chlorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264739BDBM50264739(4-(3'-chlorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264866BDBM50264866(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50: 130nMAssay Description:Inhibition of COT by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265353BDBM50265353(4-(4'-methoxybiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28042BDBM28042(5-[4-(4-phenylphenoxy)thieno[2,3-c]pyridin-2-yl]-1...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264738BDBM50264738(4-(2'-chlorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264740BDBM50264740(4-(4'-fluorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264741BDBM50264741(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50: 230nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265352BDBM50265352(4-(3'-methoxybiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl...)
Affinity DataIC50: 240nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264742BDBM50264742(2-(2H-tetrazol-5-yl)-4-(4'-(trifluoromethyl)biphen...)
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265351BDBM50265351(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265349BDBM50265349(4-(2'-methoxybiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl...)
Affinity DataIC50: 320nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265275BDBM50265275(4-(4-iodophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3-c...)
Affinity DataIC50: 410nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265276BDBM50265276(N-hydroxy-4-(4-iodophenoxy)thieno[2,3-c]pyridine-2...)
Affinity DataIC50: 540nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264742BDBM50264742(2-(2H-tetrazol-5-yl)-4-(4'-(trifluoromethyl)biphen...)
Affinity DataIC50: 560nMAssay Description:Inhibition of COT by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265312BDBM50265312(4-(4-tert-butylphenoxy)-2-(2H-tetrazol-5-yl)thieno...)
Affinity DataIC50: 610nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265311BDBM50265311(4-(4-chlorophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3...)
Affinity DataIC50: 710nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28045BDBM28045(CHEMBL523921 | 4-(4-iodophenoxy)thieno[2,3-c]pyrid...)
Affinity DataIC50: 940nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265242BDBM50265242(3-(4-(4-iodophenoxy)thieno[2,3-c]pyridin-2-yl)-1,2...)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264738BDBM50264738(4-(2'-chlorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of MEK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264741BDBM50264741(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of MEK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265310BDBM50265310(4-(4-bromophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3-...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265279BDBM50265279(4-(biphenyl-3-yloxy)-2-(2H-tetrazol-5-yl)thieno[2,...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264742BDBM50264742(2-(2H-tetrazol-5-yl)-4-(4'-(trifluoromethyl)biphen...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of MEK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264739BDBM50264739(4-(3'-chlorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of MEK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265350BDBM50265350(4-(4'-chlorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of COT by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265277BDBM50265277(4-phenoxy-2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265350BDBM50265350(4-(4'-chlorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of MEK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28042BDBM28042(5-[4-(4-phenylphenoxy)thieno[2,3-c]pyridin-2-yl]-1...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of COT by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264740BDBM50264740(4-(4'-fluorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of COT by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265309BDBM50265309(2-(2H-tetrazol-5-yl)-4-(p-tolyloxy)thieno[2,3-c]py...)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264740BDBM50264740(4-(4'-fluorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of MEK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28042BDBM28042(5-[4-(4-phenylphenoxy)thieno[2,3-c]pyridin-2-yl]-1...)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of MEK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264865BDBM50264865((4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-yl...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of MEK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265278BDBM50265278(4-(biphenyl-2-yloxy)-2-(2H-tetrazol-5-yl)thieno[2,...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264866BDBM50264866(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of MEK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265351BDBM50265351(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50: 2.12E+4nMAssay Description:Inhibition of MEK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265349BDBM50265349(4-(2'-methoxybiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl...)
Affinity DataIC50: 2.18E+4nMAssay Description:Inhibition of MEK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265352BDBM50265352(4-(3'-methoxybiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of MEK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264773BDBM50264773(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of MEK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265353BDBM50265353(4-(4'-methoxybiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl...)
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of MEK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265241BDBM50265241(N-(4-(4-iodophenoxy)thieno[2,3-c]pyridin-2-yl)acet...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265240BDBM50265240(4-(4-iodophenoxy)thieno[2,3-c]pyridin-2-amine | CH...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed