Compile Data Set for Download or QSAR
Report error Found 172 Enz. Inhib. hit(s) with all data for entry = 50038770
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264756(N-(4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-...)
Affinity DataKi:  0.800nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264993(N-(6-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biph...)
Affinity DataKi:  1.10nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264755(4-methyl-N-(3-morpholin-4-ylphenyl)-3-(3-piperidin...)
Affinity DataKi:  1.40nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265035(N-(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl...)
Affinity DataKi:  1.70nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265257(N-(4-methyl-3-(1-oxo-1,2-dihydroisoquinolin-7-yl)p...)
Affinity DataKi:  2.40nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265034(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-N...)
Affinity DataKi:  2.80nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265109(N-cyclopropyl-4-methyl-3-(4-oxo-2-(thiophen-2-yl)-...)
Affinity DataKi:  2.90nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265371(N-cyclopropyl-4-methyl-3-(3-(piperidin-4-yl)benzo[...)
Affinity DataKi:  4nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265287(N-(3-(isoquinolin-7-yl)-4-methylphenyl)-4-((4-meth...)
Affinity DataIC50: 4nMAssay Description:Inhibition of cFMSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265260(3-(isoquinolin-7-yl)-4-methyl-N-(3-morpholinopheny...)
Affinity DataKi:  4.5nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265071(3-(2-amino-4-oxo-3,4-dihydroquinazolin-6-yl)-4-met...)
Affinity DataKi:  4.70nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265154(N-cyclopropyl-3-(3-(cyclopropylmethyl)-4-oxo-3,4-d...)
Affinity DataKi:  6nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264958(N-(4'-(2-aminothiazol-4-yl)-6-methylbiphenyl-3-yl)...)
Affinity DataKi:  6.70nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265155(N-cyclopropyl-4-methyl-3-(4-oxo-2-(thiophen-2-yl)-...)
Affinity DataKi:  6.70nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265072(N-(3-(2-amino-4-oxo-3,4-dihydroquinazolin-6-yl)-4-...)
Affinity DataKi:  6.80nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265033(N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxa...)
Affinity DataKi:  10nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265259(N-cyclopropyl-3-(isoquinolin-7-yl)-4-methylbenzami...)
Affinity DataKi:  11nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265112(N-(3-(3-butyl-2,4-dioxo-1,2,3,4-tetrahydroquinazol...)
Affinity DataKi:  11nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265369(N-(3-(3-aminobenzo[d]isoxazol-6-yl)-4-methylphenyl...)
Affinity DataKi:  12nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50377985(CHEMBL1964268)
Affinity DataKi:  14nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264992(6-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-N-(3-m...)
Affinity DataKi:  17nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265198(4-methyl-N-(3-morpholinophenyl)-3-(1-oxo-1,2-dihyd...)
Affinity DataKi:  18nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265110(3-(3-butyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-...)
Affinity DataKi:  18nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265368(3-(3-aminobenzo[d]isoxazol-6-yl)-4-methyl-N-(3-mor...)
Affinity DataKi:  19nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265111(3-(3-butyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-...)
Affinity DataKi:  19nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264957(4'-(2-aminothiazol-4-yl)-6-methyl-N-(3-morpholinop...)
Affinity DataKi:  20nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50264756(N-(4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of MEK1 by cRaf/mek/Erk cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50264755(4-methyl-N-(3-morpholin-4-ylphenyl)-3-(3-piperidin...)
Affinity DataIC50: 40nMAssay Description:Inhibition of MEK1 by cRaf/mek/Erk cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265195(N-(4-methyl-3-(2-oxo-1,2-dihydroquinolin-6-yl)phen...)
Affinity DataKi:  49nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265070(3-(2-amino-4-oxo-3,4-dihydroquinazolin-6-yl)-N-cyc...)
Affinity DataKi:  49nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265287(N-(3-(isoquinolin-7-yl)-4-methylphenyl)-4-((4-meth...)
Affinity DataIC50: 70nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265325(N-cyclopropyl-3-(1H-indazol-5-yl)-4-methylbenzamid...)
Affinity DataKi:  87nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265370(N-(3-(3-aminobenzo[d]isoxazol-6-yl)-4-methylphenyl...)
Affinity DataIC50: 90nMAssay Description:Inhibition of cFMSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264990(N-(4'-(2-aminothiazol-4-yl)-6-methylbiphenyl-3-yl)...)
Affinity DataIC50: 90nMAssay Description:Inhibition of cFMSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264991(N-cyclopropyl-6-methyl-4'-(5-methyl-1,2,4-oxadiazo...)
Affinity DataKi:  98nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265069(N-(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl...)
Affinity DataIC50: 100nMAssay Description:Inhibition of cFMSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265327(3-(3-aminobenzo[d]isoxazol-6-yl)-N-cyclopropyl-4-m...)
Affinity DataKi:  110nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265326(3-(1H-indazol-5-yl)-4-methyl-N-(3-morpholinophenyl...)
Affinity DataKi:  110nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264956(4'-(2-aminothiazol-4-yl)-N-cyclopropyl-6-methylbip...)
Affinity DataKi:  130nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265324(N-(4-methyl-3-(3-methylbenzo[d]isoxazol-5-yl)pheny...)
Affinity DataKi:  160nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50265035(N-(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl...)
Affinity DataIC50: 200nMAssay Description:Inhibition of MEK1 by cRaf/mek/Erk cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265156(4-methyl-N-(3-morpholinophenyl)-3-(2-oxo-1,2-dihyd...)
Affinity DataKi:  290nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265287(N-(3-(isoquinolin-7-yl)-4-methylphenyl)-4-((4-meth...)
Affinity DataIC50: 300nMAssay Description:Inhibition of ErbB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265323(4-methyl-3-(3-methylbenzo[d]isoxazol-5-yl)-N-(3-mo...)
Affinity DataKi:  380nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50265034(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-N...)
Affinity DataIC50: 400nMAssay Description:Inhibition of MEK1 by cRaf/mek/Erk cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265197(N-cyclopropyl-4-methyl-3-(1-oxo-1,2-dihydroisoquin...)
Affinity DataKi:  420nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265288(N-cyclopropyl-4-methyl-3-(quinolin-7-yl)benzamide ...)
Affinity DataKi:  490nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265259(N-cyclopropyl-3-(isoquinolin-7-yl)-4-methylbenzami...)
Affinity DataIC50: 500nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265259(N-cyclopropyl-3-(isoquinolin-7-yl)-4-methylbenzami...)
Affinity DataIC50: 600nMAssay Description:Inhibition of cFMSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265034(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-N...)
Affinity DataIC50: 700nMAssay Description:Inhibition of cFMSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
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