Compile Data Set for Download or QSAR
maximum 50k data
Found 72 Enz. Inhib. hit(s) with all data for entry = 50027581
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256383(CHEMBL481545 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50: <2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256067(CHEMBL481685 | N3-(4-(1H-pyrazol-4-yl)phenyl)-N6-(...)
Affinity DataIC50: <2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50246409(CHEMBL455658 | N-(4-(1H-pyrazol-4-yl)phenyl)-3,4-d...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256384(6-chloro-N-(3-methoxy-4-(1H-pyrazol-4-yl)phenyl)ch...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256322(CHEMBL482336 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50: <2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256436(CHEMBL481735 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50: <2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM25472(CHEMBL519123 | N-[4-(1H-pyrazol-4-yl)phenyl]-2,3-d...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256068(6-methoxy-N-(3-methoxy-4-(1H-pyrazol-4-yl)phenyl)c...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256385(6-chloro-N-(2-methoxy-4-(1H-pyrazol-4-yl)phenyl)ch...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256163(CHEMBL474425 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256166(CHEMBL475601 | N-(4-(1H-pyrazol-4-yl)phenyl)-6-met...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256382(6-fluoro-N-(2-methoxy-4-(1H-pyrazol-4-yl)phenyl)ch...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256069(6-methoxy-N-(2-methoxy-4-(1H-pyrazol-4-yl)phenyl)c...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256111(CHEMBL480586 | N-(2-methoxy-4-(1H-pyrazol-4-yl)phe...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256110(CHEMBL480585 | N-(3-methoxy-4-(1H-pyrazol-4-yl)phe...)
Affinity DataIC50:  4nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256435(CHEMBL519269 | N-(2-methoxy-4-(1H-pyrazol-4-yl)phe...)
Affinity DataIC50:  4nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256113(CHEMBL480746 | N-(3,5-difluoro-4-(1H-pyrazol-4-yl)...)
Affinity DataIC50:  4nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256112(CHEMBL519101 | N-(2-fluoro-4-(1H-pyrazol-4-yl)phen...)
Affinity DataIC50:  4nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256223(CHEMBL475612 | N-(4-(1H-pyrazol-4-yl)phenyl)-6-flu...)
Affinity DataIC50:  4nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256386(6-chloro-N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyra...)
Affinity DataIC50:  5nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256114(CHEMBL481731 | N-(5-fluoro-2-methoxy-4-(1H-pyrazol...)
Affinity DataIC50:  5nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256224(CHEMBL475613 | N-(4-(1H-pyrazol-4-yl)phenyl)-6-chl...)
Affinity DataIC50:  5nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256383(CHEMBL481545 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50: <6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256322(CHEMBL482336 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50: <6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256323(6-fluoro-N-(3-methoxy-4-(1H-pyrazol-4-yl)phenyl)ch...)
Affinity DataIC50: <6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256386(6-chloro-N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyra...)
Affinity DataIC50: <6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256163(CHEMBL474425 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50:  6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256382(6-fluoro-N-(2-methoxy-4-(1H-pyrazol-4-yl)phenyl)ch...)
Affinity DataIC50: <6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256111(CHEMBL480586 | N-(2-methoxy-4-(1H-pyrazol-4-yl)phe...)
Affinity DataIC50:  6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256114(CHEMBL481731 | N-(5-fluoro-2-methoxy-4-(1H-pyrazol...)
Affinity DataIC50:  6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256068(6-methoxy-N-(3-methoxy-4-(1H-pyrazol-4-yl)phenyl)c...)
Affinity DataIC50: <6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256069(6-methoxy-N-(2-methoxy-4-(1H-pyrazol-4-yl)phenyl)c...)
Affinity DataIC50: <6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256110(CHEMBL480585 | N-(3-methoxy-4-(1H-pyrazol-4-yl)phe...)
Affinity DataIC50:  7nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256323(6-fluoro-N-(3-methoxy-4-(1H-pyrazol-4-yl)phenyl)ch...)
Affinity DataIC50:  7nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256162(CHEMBL514172 | N-(2-fluoro-5-methoxy-4-(1H-pyrazol...)
Affinity DataIC50:  8nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256066(CHEMBL481684 | methyl 3-(4-(1H-pyrazol-4-yl)phenyl...)
Affinity DataIC50:  10nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256225(CHEMBL482309 | N-(4-(1H-pyrazol-4-yl)phenyl)-6-met...)
Affinity DataIC50:  10nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256434(CHEMBL481889 | N-(3-methoxy-4-(1H-pyrazol-4-yl)phe...)
Affinity DataIC50:  12nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256113(CHEMBL480746 | N-(3,5-difluoro-4-(1H-pyrazol-4-yl)...)
Affinity DataIC50:  15nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256436(CHEMBL481735 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50:  16nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256162(CHEMBL514172 | N-(2-fluoro-5-methoxy-4-(1H-pyrazol...)
Affinity DataIC50:  17nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256066(CHEMBL481684 | methyl 3-(4-(1H-pyrazol-4-yl)phenyl...)
Affinity DataIC50:  22nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50246409(CHEMBL455658 | N-(4-(1H-pyrazol-4-yl)phenyl)-3,4-d...)
Affinity DataIC50:  25nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256226(3-(4-(1H-pyrazol-4-yl)phenylcarbamoyl)chroman-6-ca...)
Affinity DataIC50:  30nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256435(CHEMBL519269 | N-(2-methoxy-4-(1H-pyrazol-4-yl)phe...)
Affinity DataIC50:  35nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256384(6-chloro-N-(3-methoxy-4-(1H-pyrazol-4-yl)phenyl)ch...)
Affinity DataIC50:  38nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256166(CHEMBL475601 | N-(4-(1H-pyrazol-4-yl)phenyl)-6-met...)
Affinity DataIC50:  38nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256067(CHEMBL481685 | N3-(4-(1H-pyrazol-4-yl)phenyl)-N6-(...)
Affinity DataIC50:  47nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256434(CHEMBL481889 | N-(3-methoxy-4-(1H-pyrazol-4-yl)phe...)
Affinity DataIC50:  52nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256385(6-chloro-N-(2-methoxy-4-(1H-pyrazol-4-yl)phenyl)ch...)
Affinity DataIC50:  66nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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