Compile Data Set for Download or QSAR
Report error Found 85 Enz. Inhib. hit(s) with all data for entry = 50027717
TargetEphrin type-A receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  0.100nMAssay Description:Binding affinity to human EPHA3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to human FGRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to human FYNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of AURAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  1nMAssay Description:Binding affinity to human BLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  1nMAssay Description:Binding affinity to human YESMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  2nMAssay Description:Binding affinity to human BRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273637(3-(4-amino-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  2nMAssay Description:Binding affinity to human BRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEphrin type-A receptor 5(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  3nMAssay Description:Binding affinity to human EPHA5More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAurora kinase C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKi:  4.60nMAssay Description:Inhibition of AURCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  5nMAssay Description:Binding affinity to human EPHA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50230828([5-(p-fluorophenyl)-2-ureido]thiophene-3-carboxami...)
Affinity DataKi:  5nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEphrin type-A receptor 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  5nMAssay Description:Binding affinity to human EPHA4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase FRK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273637(3-(4-amino-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  6nMAssay Description:Binding affinity to human FRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273637(3-(4-amino-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  7nMAssay Description:Binding affinity to human FGRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  7nMAssay Description:Binding affinity to human EPHB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  8nMAssay Description:Binding affinity to human EPHA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8344(N-[6-(3-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3...)
Affinity DataIC50: 8nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  10nMAssay Description:Binding affinity to human TXKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273637(3-(4-amino-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  10nMAssay Description:Binding affinity to human EPHA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  10nMAssay Description:Binding affinity to human PYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273635(1-(4-methyl-2,5-di(pyridin-4-yl)-1H-pyrrol-3-yl)et...)
Affinity DataKd:  10nMAssay Description:Binding affinity to human CLK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8344(N-[6-(3-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3...)
Affinity DataKd:  16nMAssay Description:Binding affinity to human PIM2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKi:  18nMAssay Description:Inhibition of AURBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  19nMAssay Description:Binding affinity to human AMPKA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEphrin type-A receptor 6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  20nMAssay Description:Binding affinity to human EPHA6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50230828([5-(p-fluorophenyl)-2-ureido]thiophene-3-carboxami...)
Affinity DataIC50: 20nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50230828([5-(p-fluorophenyl)-2-ureido]thiophene-3-carboxami...)
Affinity DataKd:  22nMAssay Description:Binding affinity to human JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 16(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273541(N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl...)
Affinity DataKd:  24nMAssay Description:Binding affinity to human MPSK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)
Affinity DataIC50: 27nMAssay Description:Inhibition of TGFBR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  28nMAssay Description:Binding affinity to human CSKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273636(4-(5-(4-fluorophenyl)-1H-pyrazol-3-ylamino)benzami...)
Affinity DataKd:  30nMAssay Description:Binding affinity to human FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKi:  30nMAssay Description:Binding affinity to human FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  31nMAssay Description:Binding affinity to human MSK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  33nMAssay Description:Binding affinity to human FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetLysine--tRNA ligase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50126419(N*1*-[7-(4-Dimethylamino-phenyl)-[1,6]naphthyridin...)
Affinity DataIC50: 34nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273541(N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl...)
Affinity DataKd:  35nMAssay Description:Binding affinity to human PIM1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  36nMAssay Description:Binding affinity to human BMXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273636(4-(5-(4-fluorophenyl)-1H-pyrazol-3-ylamino)benzami...)
Affinity DataKd:  42nMAssay Description:Binding affinity to human PDGFRBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEphrin type-A receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263295(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-[(3-ter...)
Affinity DataKd:  46nMAssay Description:Binding affinity to human EPHA3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  52nMAssay Description:Binding affinity to human LTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  53nMAssay Description:Binding affinity to human KHS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAP2-associated protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273541(N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl...)
Affinity DataKd:  53nMAssay Description:Binding affinity to human AAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase I isoform delta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273635(1-(4-methyl-2,5-di(pyridin-4-yl)-1H-pyrrol-3-yl)et...)
Affinity DataKd:  58nMAssay Description:Binding affinity to human CK1deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCasein kinase I isoform gamma-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273635(1-(4-methyl-2,5-di(pyridin-4-yl)-1H-pyrrol-3-yl)et...)
Affinity DataKd:  59nMAssay Description:Binding affinity to human CK1gamma1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273541(N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl...)
Affinity DataKd:  75nMAssay Description:Binding affinity to human MST2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  75nMAssay Description:Binding affinity to human TYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  77nMAssay Description:Binding affinity to human ROSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 12(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273542(4'-Amino-4''-sulfamoyl-[1,1';3',1'']terphenyl-4,5'...)
Affinity DataKd:  79nMAssay Description:Binding affinity to human p38-gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273637(3-(4-amino-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  80nMAssay Description:Binding affinity to human TXKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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