Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 3058
LigandPNGBDBM27427(8-methyl-11-thia-9,14,16-triazatetracyclo[8.7.0.0^...)
Affinity DataKi:  0.5nM ΔG°:  -55.2kJ/mole IC50: 5nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27428(12-ethyl-11,13-dimethyl-8-thia-3,5,10-triazatricyc...)
Affinity DataKi:  1nM ΔG°:  -53.4kJ/mole IC50: 10nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27429(9-methyl-17-thia-2,12,14-triazatetracyclo[8.7.0.0^...)
Affinity DataKi:  2nM ΔG°:  -51.6kJ/mole IC50: 20nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27430(11,13-dimethyl-12-(prop-2-en-1-yl)-8-thia-3,5,10-t...)
Affinity DataKi:  2nM ΔG°:  -51.6kJ/mole IC50: 20nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27431(7-methyl-10-thia-8,13,15-triazatetracyclo[7.7.0.0^...)
Affinity DataKi:  3nM ΔG°:  -50.6kJ/mole IC50: 30nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27432(11,12,13-trimethyl-8-thia-3,5,10-triazatricyclo[7....)
Affinity DataKi:  4nM ΔG°:  -49.9kJ/mole IC50: 40nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27433(16-methyl-8-thia-3,5,10-triazatetracyclo[7.7.0.0^{...)
Affinity DataKi:  5nM ΔG°:  -49.3kJ/mole IC50: 50nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27434(11,13-dimethyl-8-thia-3,5,10-triazatricyclo[7.4.0....)
Affinity DataKi:  40nM ΔG°:  -43.9kJ/mole IC50: 400nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27435(12-benzyl-11,13-dimethyl-8-thia-3,5,10-triazatricy...)
Affinity DataKi:  200nM ΔG°:  -39.8kJ/mole IC50: 2.00E+3nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27436(11-cyclopropyl-13-(trifluoromethyl)-8-thia-3,5,10-...)
Affinity DataKi:  400nM ΔG°:  -38.0kJ/mole IC50: 4.00E+3nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27437(12-phenyl-8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,...)
Affinity DataKi:  900nM ΔG°:  -35.9kJ/mole IC50: 9.00E+3nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27438(ethyl 6-amino-11-methyl-8-thia-3,5,10-triazatricyc...)
Affinity DataKi:  1.00E+3nM ΔG°:  -35.6kJ/mole IC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27439(8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca...)
Affinity DataKi:  1.20E+3nM ΔG°:  -35.2kJ/mole IC50: 1.20E+4nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27440(N,11,13-trimethyl-8-thia-3,5,10-triazatricyclo[7.4...)
Affinity DataKi: >3.00E+3nM ΔG°: >-32.8kJ/mole IC50: 3.00E+4nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27441(N,N,11,13-tetramethyl-8-thia-3,5,10-triazatricyclo...)
Affinity DataKi: >3.00E+3nM ΔG°: >-32.8kJ/mole IC50: 3.00E+4nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27442(11,13-dimethyl-N-phenyl-8-thia-3,5,10-triazatricyc...)
Affinity DataKi: >3.00E+3nM ΔG°: >-32.8kJ/mole IC50: 3.00E+4nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed