Compile Data Set for Download or QSAR
maximum 50k data
Found 59 Enz. Inhib. hit(s) with all data for entry = 50038838
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277189((R)-6-methyl-N-(2-(thiazol-2-ylmethylamino)-2,3-di...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50107789((R)-methyl 5-(6-methyl-4'-(trifluoromethyl)bipheny...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50107786((R)-6-methyl-N-(2-(pyridin-2-ylmethylamino)-2,3-di...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277330((S)-6-methyl-N-(2-((4-methylthiazol-2-yl)methylami...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50107813((S)-methyl 5-(6-methyl-4'-(trifluoromethyl)bipheny...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277332((S)-6-methyl-N-(2-((5-methylfuran-2-yl)methylamino...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277297((S)-6-methyl-N-(2-(thiophen-2-ylmethylamino)-2,3-d...)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277330((S)-6-methyl-N-(2-((4-methylthiazol-2-yl)methylami...)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277258((S)-N-(2-(benzylamino)-2,3-dihydro-1H-inden-5-yl)-...)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277297((S)-6-methyl-N-(2-(thiophen-2-ylmethylamino)-2,3-d...)
Affinity DataIC50:  9nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277332((S)-6-methyl-N-(2-((5-methylfuran-2-yl)methylamino...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277190((S)-6-methyl-N-(2-(thiazol-2-ylmethylamino)-2,3-di...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277298((S)-N-(2-(furan-2-ylmethylamino)-2,3-dihydro-1H-in...)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277258((S)-N-(2-(benzylamino)-2,3-dihydro-1H-inden-5-yl)-...)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277293(6-methyl-N-((2S)-2-(1-phenylethylamino)-2,3-dihydr...)
Affinity DataIC50:  29nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277190((S)-6-methyl-N-(2-(thiazol-2-ylmethylamino)-2,3-di...)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277293(6-methyl-N-((2S)-2-(1-phenylethylamino)-2,3-dihydr...)
Affinity DataIC50:  32nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277294(6-methyl-N-((2S)-2-(2,2,2-trifluoro-1-phenylethyla...)
Affinity DataIC50:  55nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277294(6-methyl-N-((2S)-2-(2,2,2-trifluoro-1-phenylethyla...)
Affinity DataIC50:  57nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50107787((S)-6-methyl-N-(2-(pyridin-2-ylmethylamino)-2,3-di...)
Affinity DataIC50:  57nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277296((S)-6-methyl-N-(2-(phenylamino)-2,3-dihydro-1H-ind...)
Affinity DataIC50:  82nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277260((S)-N-(2-(4-methoxybenzylamino)-2,3-dihydro-1H-ind...)
Affinity DataIC50:  93nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277151(CHEMBL474281 | rac-6-methyl-N-(2-(pyridin-2-ylmeth...)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277331((S)-6-methyl-N-(2-((4-methylthiazol-5-yl)methylami...)
Affinity DataIC50:  120nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277260((S)-N-(2-(4-methoxybenzylamino)-2,3-dihydro-1H-ind...)
Affinity DataIC50:  120nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50107787((S)-6-methyl-N-(2-(pyridin-2-ylmethylamino)-2,3-di...)
Affinity DataIC50:  120nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277296((S)-6-methyl-N-(2-(phenylamino)-2,3-dihydro-1H-ind...)
Affinity DataIC50:  130nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277297((S)-6-methyl-N-(2-(thiophen-2-ylmethylamino)-2,3-d...)
Affinity DataIC50:  140nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277190((S)-6-methyl-N-(2-(thiazol-2-ylmethylamino)-2,3-di...)
Affinity DataIC50:  140nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277298((S)-N-(2-(furan-2-ylmethylamino)-2,3-dihydro-1H-in...)
Affinity DataIC50:  150nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277331((S)-6-methyl-N-(2-((4-methylthiazol-5-yl)methylami...)
Affinity DataIC50:  170nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277293(6-methyl-N-((2S)-2-(1-phenylethylamino)-2,3-dihydr...)
Affinity DataIC50:  180nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277259((S)-6-methyl-N-(2-(pyridin-4-ylmethylamino)-2,3-di...)
Affinity DataIC50:  190nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277295((S)-6-methyl-N-(2-(quinolin-3-ylmethylamino)-2,3-d...)
Affinity DataIC50:  210nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277259((S)-6-methyl-N-(2-(pyridin-4-ylmethylamino)-2,3-di...)
Affinity DataIC50:  240nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50232973(CHEMBL254129 | CYCLOPAMINE)
Affinity DataIC50:  280nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277261((S)-N-(2-(4-acetamidobenzylamino)-2,3-dihydro-1H-i...)
Affinity DataIC50:  340nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277295((S)-6-methyl-N-(2-(quinolin-3-ylmethylamino)-2,3-d...)
Affinity DataIC50:  350nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277261((S)-N-(2-(4-acetamidobenzylamino)-2,3-dihydro-1H-i...)
Affinity DataIC50:  360nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277221(CHEMBL473892 | rac-N-(2-(pyridin-2-ylmethylamino)-...)
Affinity DataIC50:  490nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277189((R)-6-methyl-N-(2-(thiazol-2-ylmethylamino)-2,3-di...)
Affinity DataIC50:  770nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277221(CHEMBL473892 | rac-N-(2-(pyridin-2-ylmethylamino)-...)
Affinity DataIC50:  790nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277223(CHEMBL515245 | rac-N-(2-(pyridin-2-ylmethylamino)-...)
Affinity DataIC50:  1.15E+3nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277189((R)-6-methyl-N-(2-(thiazol-2-ylmethylamino)-2,3-di...)
Affinity DataIC50:  1.19E+3nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50232973(CHEMBL254129 | CYCLOPAMINE)
Affinity DataIC50:  1.20E+3nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277295((S)-6-methyl-N-(2-(quinolin-3-ylmethylamino)-2,3-d...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277223(CHEMBL515245 | rac-N-(2-(pyridin-2-ylmethylamino)-...)
Affinity DataIC50:  1.42E+3nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50107787((S)-6-methyl-N-(2-(pyridin-2-ylmethylamino)-2,3-di...)
Affinity DataIC50:  2.35E+3nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50107789((R)-methyl 5-(6-methyl-4'-(trifluoromethyl)bipheny...)
Affinity DataIC50:  2.48E+3nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277132(CHEMBL473703 | rac-methyl 5-(6-methyl-4'-(trifluor...)
Affinity DataIC50:  2.70E+3nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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