Compile Data Set for Download or QSAR
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50027999
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256760(9-(4,5-Dimethoxy-2-nitro-benzyloxy)-13-ethyl-2,3,1...)
Affinity DataIC50: 170nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256650(13-(3,5-Dimethoxy-benzyl)-9,10-dimethoxy-5,6-dihyd...)
Affinity DataIC50: 260nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50087267((S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-ox...)
Affinity DataIC50: 340nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256602(13-Ethyl-9,10-dimethoxy-5,6-dihydro-[1,3]dioxolo[4...)
Affinity DataIC50: 350nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256651(13-(2-Chloro-6-fluoro-benzyl)-9,10-dimethoxy-5,6-d...)
Affinity DataIC50: 400nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256736(13-Ethyl-2,3,10-trimethoxy-9-(2-methoxy-5-nitro-be...)
Affinity DataIC50: 420nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256604(13-(1-Iodo-butyl)-9,10-dimethoxy-5,6-dihydro-[1,3]...)
Affinity DataIC50: 420nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256603(13-Allyl-9,10-dimethoxy-5,6-dihydro-[1,3]dioxolo[4...)
Affinity DataIC50: 440nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256652(2,3,9,10-Tetramethoxy-13-propyl-5,6-dihydro-isoqui...)
Affinity DataIC50: 500nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256601((13R,13aS)-13-Ethyl-9,10-dimethoxy-5,8,13,13a-tetr...)
Affinity DataIC50: 560nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256737(13-Ethyl-2,3,10-trimethoxy-9-(5-methyl-2-nitro-ben...)
Affinity DataIC50: 730nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256735(13-Ethyl-9-(4-fluoro-2-trifluoromethyl-benzyloxy)-...)
Affinity DataIC50: 820nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256653(13-Cyclohexylmethyl-2,3,9,10-tetramethoxy-5,6-dihy...)
Affinity DataIC50: 1.12E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256761(9-(4-tert-Butyl-benzyloxy)-13-ethyl-2,3,10-trimeth...)
Affinity DataIC50: 1.26E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256759(9-(2,5-Dimethyl-benzyloxy)-13-ethyl-2,3,10-trimeth...)
Affinity DataIC50: 1.53E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256692(13-Ethyl-2,3,10-trimethoxy-9-(2-trifluoromethyl-be...)
Affinity DataIC50: 2.56E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256762(9-(4-Bromo-benzyloxy)-13-ethyl-2,3,10-trimethoxy-5...)
Affinity DataIC50: 2.60E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50255993(9-(3-Chloro-benzyloxy)-13-ethyl-2,3,10-trimethoxy-...)
Affinity DataIC50: 2.66E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256763(9-(4-Benzyloxy-benzyloxy)-13-ethyl-2,3,10-trimetho...)
Affinity DataIC50: 2.81E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256764(9-(Biphenyl-4-ylmethoxy)-13-ethyl-2,3,10-trimethox...)
Affinity DataIC50: 3.22E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50255994(9-(6-Chloro-pyridin-3-ylmethoxy)-13-ethyl-2,3,10-t...)
Affinity DataIC50: 4.41E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256691(13-Ethyl-2,3,10-trimethoxy-9-(2-methyl-benzyloxy)-...)
Affinity DataIC50: 5.02E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM50256693(13-Ethyl-2,3,10-trimethoxy-9-(2-methyl-3-nitro-ben...)
Affinity DataIC50: 5.40E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed