Compile Data Set for Download or QSAR
Report error Found 57 Enz. Inhib. hit(s) with all data for entry = 50028145
TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 8960BDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of AChE in rat cortex preincubated for 20 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276552BDBM50276552((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[(1-benzylpipe...)
Affinity DataIC50: 55nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16047BDBM16047(EVNXXAEF | N-{(2R,4S,5S)-5-[(L-alpha-glutamyl-L-va...)
Affinity DataIC50: 71nMAssay Description:Inhibition of human recombinant C-terminal histidine-tagged BACE1 expressed in baculovirus-infected insect cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276554BDBM50276554((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpi...)
Affinity DataIC50: 99nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276557BDBM50276557((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpi...)
Affinity DataIC50: 222nMAssay Description:Inhibition of human recombinant C-terminal histidine-tagged BACE1 expressed in baculovirus-infected insect cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16689BDBM16689(1-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-N-[(2S)-1-hyd...)
Affinity DataIC50: 462nMAssay Description:Inhibition of human recombinant C-terminal histidine-tagged BACE1 expressed in baculovirus-infected insect cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276552BDBM50276552((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[(1-benzylpipe...)
Affinity DataIC50: 511nMAssay Description:Inhibition of human recombinant C-terminal histidine-tagged BACE1 expressed in baculovirus-infected insect cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276554BDBM50276554((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpi...)
Affinity DataIC50: 567nMAssay Description:Inhibition of human recombinant C-terminal histidine-tagged BACE1 expressed in baculovirus-infected insect cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276539BDBM50276539(N-{(4S,5S,7R)-2-[7-(1-Benzylpiperidin-4-yl)]methyl...)
Affinity DataIC50: 616nMAssay Description:Inhibition of human recombinant C-terminal histidine-tagged BACE1 expressed in baculovirus-infected insect cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276555BDBM50276555((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[(1-benzylpipe...)
Affinity DataIC50: 771nMAssay Description:Inhibition of human recombinant C-terminal histidine-tagged BACE1 expressed in baculovirus-infected insect cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276616BDBM50276616((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16689BDBM16689(1-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-N-[(2S)-1-hyd...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276538BDBM50276538(N-[(4S,5S,7R)-7-(1-Benzylpiperidin-4-yl)carbamoyl-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50025100BDBM50025100(CHEMBL449152)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276558BDBM50276558((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276557BDBM50276557((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276556BDBM50276556((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[(1-benzylpipe...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276555BDBM50276555((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[(1-benzylpipe...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276553BDBM50276553((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[(1-benzylpipe...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50025101BDBM50025101(CHEMBL505994)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50025102BDBM50025102(CHEMBL505749)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276551BDBM50276551(N-{[2S,3(R,S)]-2-[4-(1-Benzylpiperidin-4-yl)]ethyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50025122BDBM50025122(CHEMBL507252)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50025123BDBM50025123(CHEMBL501507)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276548BDBM50276548(N-{[2S,3(R,S)]-2-[4-(1-Benzylpiperidin-4-yl)]ethyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276545BDBM50276545(N-{[2S,3(R,S)]-2-[4-(1-Benzylpiperidin-4-yl)]ethyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50025126BDBM50025126(CHEMBL499502)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50025125BDBM50025125(CHEMBL504664)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276542BDBM50276542(N-{(4S,5S,7R)-2-[7-(1-Benzylpiperidin-4-yl)]carbam...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276560BDBM50276560((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50025140BDBM50025140(CHEMBL503126)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276539BDBM50276539(N-{(4S,5S,7R)-2-[7-(1-Benzylpiperidin-4-yl)]methyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276561BDBM50276561((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276617BDBM50276617((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276559BDBM50276559((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276618BDBM50276618((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276540BDBM50276540(N-{(4S,5S,7R)-2-[7-(1-Benzylpiperidin-4-yl)]ethylc...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276558BDBM50276558((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpi...)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of AChE in rat cortex preincubated for 20 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276545BDBM50276545(N-{[2S,3(R,S)]-2-[4-(1-Benzylpiperidin-4-yl)]ethyl...)
Affinity DataIC50: 1.11E+3nMAssay Description:Inhibition of AChE in rat cortex preincubated for 20 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276561BDBM50276561((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpi...)
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of AChE in rat cortex preincubated for 20 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276540BDBM50276540(N-{(4S,5S,7R)-2-[7-(1-Benzylpiperidin-4-yl)]ethylc...)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of human recombinant C-terminal histidine-tagged BACE1 expressed in baculovirus-infected insect cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276557BDBM50276557((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpi...)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of AChE in rat cortex preincubated for 20 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276548BDBM50276548(N-{[2S,3(R,S)]-2-[4-(1-Benzylpiperidin-4-yl)]ethyl...)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of AChE in rat cortex preincubated for 20 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276538BDBM50276538(N-[(4S,5S,7R)-7-(1-Benzylpiperidin-4-yl)carbamoyl-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human recombinant C-terminal histidine-tagged BACE1 expressed in baculovirus-infected insect cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276542BDBM50276542(N-{(4S,5S,7R)-2-[7-(1-Benzylpiperidin-4-yl)]carbam...)
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of human recombinant C-terminal histidine-tagged BACE1 expressed in baculovirus-infected insect cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276551BDBM50276551(N-{[2S,3(R,S)]-2-[4-(1-Benzylpiperidin-4-yl)]ethyl...)
Affinity DataIC50: 1.68E+3nMAssay Description:Inhibition of AChE in rat cortex preincubated for 20 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276554BDBM50276554((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpi...)
Affinity DataIC50: 1.83E+3nMAssay Description:Inhibition of AChE in rat cortex preincubated for 20 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276560BDBM50276560((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpi...)
Affinity DataIC50: 2.09E+3nMAssay Description:Inhibition of AChE in rat cortex preincubated for 20 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276618BDBM50276618((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpi...)
Affinity DataIC50: 2.28E+3nMAssay Description:Inhibition of AChE in rat cortex preincubated for 20 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50276558BDBM50276558((1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpi...)
Affinity DataIC50: 2.39E+3nMAssay Description:Inhibition of human recombinant C-terminal histidine-tagged BACE1 expressed in baculovirus-infected insect cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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