Compile Data Set for Download or QSAR
Report error Found 104 Enz. Inhib. hit(s) with all data for entry = 50028338
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257857BDBM50257857((S)-N-(5-(((3,3-dimethylbutan-2-yl)(methyl)amino)m...)
Affinity DataIC50: 1nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257918BDBM50257918(N-(5-((3,5-dimethylmorpholino)methyl)-1-(2-hydroxy...)
Affinity DataIC50: 1nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257699BDBM50257699(N-(5-((cyclohexylamino)methyl)-1-(2-hydroxy-2-meth...)
Affinity DataIC50: 1nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257755BDBM50257755(N-(5-((benzylamino)methyl)-1-(2-hydroxy-2-methylpr...)
Affinity DataIC50: 1nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257805BDBM50257805(N-(1-(2-hydroxy-2-methylpropyl)-5-((isobutylamino)...)
Affinity DataIC50: 1nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257806BDBM50257806((R)-N-(5-((3,3-dimethylbutan-2-ylamino)methyl)-1-(...)
Affinity DataIC50: 1nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257855BDBM50257855((R)-N-(5-(((3,3-dimethylbutan-2-yl)(methyl)amino)m...)
Affinity DataIC50: 1nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257856BDBM50257856((S)-N-(5-((3,3-dimethylbutan-2-ylamino)methyl)-1-(...)
Affinity DataIC50: 1nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257803BDBM50257803(N-(1-(2-hydroxy-2-methylpropyl)-5-((methyl(pyridin...)
Affinity DataIC50: 1nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257917BDBM50257917(N-(1-(2-hydroxy-2-methylpropyl)-5-(morpholinomethy...)
Affinity DataIC50: 2nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257697BDBM50257697(N-(1-(2-hydroxy-2-methylpropyl)-5-((phenylamino)me...)
Affinity DataIC50: 2nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257858BDBM50257858(N-(5-(((2-(dimethylamino)ethyl)(methyl)amino)methy...)
Affinity DataIC50: 2nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257698BDBM50257698(N-(5-((cyclohexyl(methyl)amino)methyl)-1-(2-hydrox...)
Affinity DataIC50: 2nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257804BDBM50257804(N-(5-((sec-butylamino)methyl)-1-(2-hydroxy-2-methy...)
Affinity DataIC50: 2nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257855BDBM50257855((R)-N-(5-(((3,3-dimethylbutan-2-yl)(methyl)amino)m...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257753BDBM50257753(N-(1-(2-hydroxy-2-methylpropyl)-5-((methylamino)me...)
Affinity DataIC50: 2nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257962BDBM50257962(N-(1-(2-hydroxy-2-methylpropyl)-5-((3-hydroxypyrro...)
Affinity DataIC50: 2nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257806BDBM50257806((R)-N-(5-((3,3-dimethylbutan-2-ylamino)methyl)-1-(...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257918BDBM50257918(N-(5-((3,5-dimethylmorpholino)methyl)-1-(2-hydroxy...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257754BDBM50257754(N-(5-((dimethylamino)methyl)-1-(2-hydroxy-2-methyl...)
Affinity DataIC50: 3nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257857BDBM50257857((S)-N-(5-(((3,3-dimethylbutan-2-yl)(methyl)amino)m...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257549BDBM50257549(N-(1-(2-hydroxy-2-methylpropyl)-5-(N-methylbenzami...)
Affinity DataIC50: 3nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257916BDBM50257916(N-(1-(2-hydroxy-2-methylpropyl)-5-((2-(hydroxymeth...)
Affinity DataIC50: 3nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257915BDBM50257915(N-(1-(2-hydroxy-2-methylpropyl)-5-(piperidin-1-ylm...)
Affinity DataIC50: 3nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257856BDBM50257856((S)-N-(5-((3,3-dimethylbutan-2-ylamino)methyl)-1-(...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257752BDBM50257752(N-(5-(aminomethyl)-1-(2-hydroxy-2-methylpropyl)-1H...)
Affinity DataIC50: 4nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257803BDBM50257803(N-(1-(2-hydroxy-2-methylpropyl)-5-((methyl(pyridin...)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257696BDBM50257696(N-(1-(2-hydroxy-2-methylpropyl)-5-((methyl(phenyl)...)
Affinity DataIC50: 8nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257857BDBM50257857((S)-N-(5-(((3,3-dimethylbutan-2-yl)(methyl)amino)m...)
Affinity DataIC50: 8nMAssay Description:Inhibition of ITK in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257656BDBM50257656(N-(5-((cyclohexylamino)methyl)-1-(2-hydroxy-2-meth...)
Affinity DataIC50: 8nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257655BDBM50257655(N-(5-((cyclohexyl(methyl)amino)methyl)-1-(2-hydrox...)
Affinity DataIC50: 8nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257654BDBM50257654(N-(1-(2-hydroxy-2-methylpropyl)-5-((phenylamino)me...)
Affinity DataIC50: 11nMAssay Description:Binding affinity to ITK by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257915BDBM50257915(N-(1-(2-hydroxy-2-methylpropyl)-5-(piperidin-1-ylm...)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257805BDBM50257805(N-(1-(2-hydroxy-2-methylpropyl)-5-((isobutylamino)...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257856BDBM50257856((S)-N-(5-((3,3-dimethylbutan-2-ylamino)methyl)-1-(...)
Affinity DataIC50: 13nMAssay Description:Inhibition of ITK in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257917BDBM50257917(N-(1-(2-hydroxy-2-methylpropyl)-5-(morpholinomethy...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257698BDBM50257698(N-(5-((cyclohexyl(methyl)amino)methyl)-1-(2-hydrox...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257755BDBM50257755(N-(5-((benzylamino)methyl)-1-(2-hydroxy-2-methylpr...)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257855BDBM50257855((R)-N-(5-(((3,3-dimethylbutan-2-yl)(methyl)amino)m...)
Affinity DataIC50: 20nMAssay Description:Inhibition of ITK in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257806BDBM50257806((R)-N-(5-((3,3-dimethylbutan-2-ylamino)methyl)-1-(...)
Affinity DataIC50: 20nMAssay Description:Inhibition of ITK in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257699BDBM50257699(N-(5-((cyclohexylamino)methyl)-1-(2-hydroxy-2-meth...)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257697BDBM50257697(N-(1-(2-hydroxy-2-methylpropyl)-5-((phenylamino)me...)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257804BDBM50257804(N-(5-((sec-butylamino)methyl)-1-(2-hydroxy-2-methy...)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257754BDBM50257754(N-(5-((dimethylamino)methyl)-1-(2-hydroxy-2-methyl...)
Affinity DataIC50: 26nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257916BDBM50257916(N-(1-(2-hydroxy-2-methylpropyl)-5-((2-(hydroxymeth...)
Affinity DataIC50: 58nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257858BDBM50257858(N-(5-(((2-(dimethylamino)ethyl)(methyl)amino)methy...)
Affinity DataIC50: 62nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257697BDBM50257697(N-(1-(2-hydroxy-2-methylpropyl)-5-((phenylamino)me...)
Affinity DataIC50: 75nMAssay Description:Inhibition of ITK in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257806BDBM50257806((R)-N-(5-((3,3-dimethylbutan-2-ylamino)methyl)-1-(...)
Affinity DataIC50: 93nMAssay Description:Inhibition of IRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257918BDBM50257918(N-(5-((3,5-dimethylmorpholino)methyl)-1-(2-hydroxy...)
Affinity DataIC50: 98nMAssay Description:Inhibition of ITK in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257699BDBM50257699(N-(5-((cyclohexylamino)methyl)-1-(2-hydroxy-2-meth...)
Affinity DataIC50: 99nMAssay Description:Inhibition of ITK in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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