Compile Data Set for Download or QSAR
Report error Found 49 Enz. Inhib. hit(s) with all data for entry = 50028562
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259007(N-({4'-[(4-isobutyrylphenoxy)methyl]biphenyl-4-yl}...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259007(N-({4'-[(4-isobutyrylphenoxy)methyl]biphenyl-4-yl}...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259009((R)-3-methyl-2-(4'-((5-oxo-5,6,7,8-tetrahydronapht...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258875((R)-2-(4'-((4-(4-fluorobenzoyl)phenoxy)methyl)biph...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258917((R)-2-(4'-((4-(cyclohexanecarbonyl)phenoxy)methyl)...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259009((R)-3-methyl-2-(4'-((5-oxo-5,6,7,8-tetrahydronapht...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258875((R)-2-(4'-((4-(4-fluorobenzoyl)phenoxy)methyl)biph...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258917((R)-2-(4'-((4-(cyclohexanecarbonyl)phenoxy)methyl)...)
Affinity DataIC50: 15nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50258875((R)-2-(4'-((4-(4-fluorobenzoyl)phenoxy)methyl)biph...)
Affinity DataIC50: 80nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50258917((R)-2-(4'-((4-(cyclohexanecarbonyl)phenoxy)methyl)...)
Affinity DataIC50: 90nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259007(N-({4'-[(4-isobutyrylphenoxy)methyl]biphenyl-4-yl}...)
Affinity DataIC50: 100nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259010((R)-2-(3-fluoro-4'-((5-oxo-5,6,7,8-tetrahydronapht...)
Affinity DataIC50: 180nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50258873((R)-3-methyl-2-(4'-((3-methylquinolin-2-yloxy)meth...)
Affinity DataIC50: 200nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50258874((R)-2-(4'-((2,8-bis(trifluoromethyl)quinolin-3-ylo...)
Affinity DataIC50: 200nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258875((R)-2-(4'-((4-(4-fluorobenzoyl)phenoxy)methyl)biph...)
Affinity DataIC50: 220nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259052((R)-2-(4'-((4-benzoylphenoxy)methyl)biphenyl-4-yls...)
Affinity DataIC50: 230nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259009((R)-3-methyl-2-(4'-((5-oxo-5,6,7,8-tetrahydronapht...)
Affinity DataIC50: 230nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM24040(CHEMBL200221 | (2R)-2-({4-[4-(1-benzofuran-2-ylcar...)
Affinity DataIC50: 350nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259546((R)-3-methyl-2-(4'-((4-phenoxyphenoxy)methyl)biphe...)
Affinity DataIC50: 400nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50258872((R)-3-methyl-2-(4'-((quinolin-2-yloxy)methyl)biphe...)
Affinity DataIC50: 400nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259095((R)-2-(4'-((4-acetylphenoxy)methyl)biphenyl-4-ylsu...)
Affinity DataIC50: 430nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259096((R)-2-(4'-((4-(tert-butoxycarbonylamino)phenoxy)me...)
Affinity DataIC50: 590nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259545((R)-3-methyl-2-(4'-(2-(3-methylbenzofuran-2-yl)ace...)
Affinity DataIC50: 700nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259547((R)-3-methyl-2-(4'-((4-(6-methylpyridin-2-yloxy)ph...)
Affinity DataIC50: 730nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50258871((R)-3-methyl-2-(4'-((5-(trifluoromethyl)pyridin-2-...)
Affinity DataIC50: 800nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259575((R)-3-methyl-2-(4'-((4-(pyridin-2-yloxy)phenoxy)me...)
Affinity DataIC50: 900nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259007(N-({4'-[(4-isobutyrylphenoxy)methyl]biphenyl-4-yl}...)
Affinity DataIC50: 915nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259008((R)-2-(4'-((3-acetylphenoxy)methyl)biphenyl-4-ylsu...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259576((R)-2-(4'-((3-hydroxyphenoxy)methyl)biphenyl-4-yls...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259577((R)-2-(4'-((3-fluorophenoxy)methyl)biphenyl-4-ylsu...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259009((R)-3-methyl-2-(4'-((5-oxo-5,6,7,8-tetrahydronapht...)
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259608((R)-2-(4'-((4-methoxyphenoxy)methyl)biphenyl-4-yls...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258917((R)-2-(4'-((4-(cyclohexanecarbonyl)phenoxy)methyl)...)
Affinity DataIC50: 1.64E+3nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259609((R)-2-(4'-((4-fluorophenoxy)methyl)biphenyl-4-ylsu...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259578((R)-2-(4'-((3-methoxyphenoxy)methyl)biphenyl-4-yls...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259097((R)-3-methyl-2-(4'-((4-(pyrrolidine-1-carbonyl)phe...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50258917((R)-2-(4'-((4-(cyclohexanecarbonyl)phenoxy)methyl)...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of aggrecanase2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM24025((2R)-3-methyl-2-[(4-phenylbenzene)sulfonamido]buta...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259050((R)-3-methyl-2-(4'-((5-oxo-5,6,7,8-tetrahydronapht...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259607((R)-2-(4'-((3-(dimethylamino)phenoxy)methyl)biphen...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259141((R)-3-methyl-2-(4'-((4-(morpholine-4-carbonyl)phen...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259610((R)-3-methyl-2-(4'-((4-(morpholinomethyl)phenoxy)m...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259009((R)-3-methyl-2-(4'-((5-oxo-5,6,7,8-tetrahydronapht...)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of aggrecanase2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259007(N-({4'-[(4-isobutyrylphenoxy)methyl]biphenyl-4-yl}...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of aggrecanase2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50259051((R)-3-methyl-2-(4'-((5-oxo-5,6,7,8-tetrahydronapht...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of aggrecanase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258917((R)-2-(4'-((4-(cyclohexanecarbonyl)phenoxy)methyl)...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258875((R)-2-(4'-((4-(4-fluorobenzoyl)phenoxy)methyl)biph...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259009((R)-3-methyl-2-(4'-((5-oxo-5,6,7,8-tetrahydronapht...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259007(N-({4'-[(4-isobutyrylphenoxy)methyl]biphenyl-4-yl}...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed