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Found 21 Enz. Inhib. hit(s) with all data for entry = 50039085
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataKi:  300nMAssay Description:Inhibition of human carbonic anhydrase 2 by ThermoFluor methodMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310430(CHEMBL1084919 | N-[(4-bromo-1-benzothien-3-yl)meth...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310434(CHEMBL1077117 | N-(1-benzofuran-3-ylmethyl)sulfami...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310436(CHEMBL1084675 | N-[(5-chloro-1-benzothien-3-yl)met...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310429(CHEMBL1088203 | N-(1-naphthylmethyl)sulfamide)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50003655(Phenytoin)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of rat Nav1.2 channel expressed in chinese hamster CHL1610 cells at preconditioning pulse of -67 mV after 2 to 3 mins by whole-cell patch-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310433(CHEMBL1077134 | N-[(2-methyl-1-benzofuran-3-yl)met...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(CHEMBL466517 | JNJ-26990990 | N-((Benzo[b]thien-3-...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of carbonic anhydrase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310431(CHEMBL1084918 | N-[(5-fluoro-1-benzothien-3-yl)met...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50031299(6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamin...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of rat Nav1.2 channel expressed in chinese hamster CHL1610 cells at preconditioning pulse of -67 mV after 2 to 3 mins by whole-cell patch-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310438(CHEMBL1086777 | N-[(5-methyl-1-benzothien-3-yl)met...)
Affinity DataIC50:  4.50E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310432(CHEMBL1084674 | N-[(1-methyl-1H-indol-3-yl)methyl]...)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(CHEMBL466517 | JNJ-26990990 | N-((Benzo[b]thien-3-...)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibition of rat Nav1.2 channel expressed in chinese hamster CHL1610 cells at preconditioning pulse of -67 mV after 2 to 3 mins by whole-cell patch-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(CHEMBL466517 | JNJ-26990990 | N-((Benzo[b]thien-3-...)
Affinity DataIC50:  6.60E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by fluorimetric assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataIC50:  9.70E+4nMAssay Description:Inhibition of rat Nav1.2 channel expressed in chinese hamster CHL1610 cells at preconditioning pulse of -67 mV after 2 to 3 mins by whole-cell patch-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310435(CHEMBL1084920 | N-[(5-bromo-1-benzothien-3-yl)meth...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(CHEMBL466517 | JNJ-26990990 | N-((Benzo[b]thien-3-...)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310428(CHEMBL1088204 | rac-N-[1-(1-benzothien-3-yl)ethyl]...)
Affinity DataIC50:  1.30E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Rattus norvegicus (Rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(CHEMBL466517 | JNJ-26990990 | N-((Benzo[b]thien-3-...)
Affinity DataIC50:  1.33E+5nMAssay Description:Inhibition of rat Cav2.2 channel expressed in 0.07 Hz frequency-stimulated HEK cells by whole-cell patch-clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310437(CHEMBL1084673 | N-(1H-indol-3-ylmethyl)sulfamide)
Affinity DataIC50:  3.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed