Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50030286
TargetHistone deacetylase 1(Human)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM19130(CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of HDAC1 in human NIH3T3 cells by radiometric histone deacetylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 27nMAssay Description:Inhibition of HDAC1 by fluorogenic enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1(Human)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)
Affinity DataIC50: 44nMAssay Description:Inhibition of HDAC1 in human NIH3T3 cells by radiometric histone deacetylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataIC50: 120nMAssay Description:Inhibition of HDAC1 by fluorogenic enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM50293704(1,1,1-trifluoro-7-(1H-naphtho[2,3-d]imidazol-2-yl)...)
Affinity DataIC50: 600nMAssay Description:Inhibition of Bordetella / Alcaligenes strain FB188 HDAH by fluorogenic enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM50293703(2-ethyl-3-methoxy-6-methyl-5-(11-oxododecyl)cycloh...)
Affinity DataIC50: 600nMAssay Description:Inhibition of Bordetella / Alcaligenes strain FB188 HDAH by fluorogenic enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM19130(CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...)
Affinity DataKi:  700nMAssay Description:Displacement of Atto700-HA from Bordetella / Alcaligenes strain FB188 HDAH by fluorescence anisotropyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Bordetella / Alcaligenes strain FB188 HDAH by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to Bordetella / Alcaligenes strain FB188 HDAC by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM50293703(2-ethyl-3-methoxy-6-methyl-5-(11-oxododecyl)cycloh...)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of Atto700-HA from Bordetella / Alcaligenes strain FB188 HDAH by fluorescence anisotropyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM19130(CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of Bordetella / Alcaligenes strain FB188 HDAH by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataKi:  1.30E+3nMAssay Description:Displacement of Atto700-HA from Bordetella / Alcaligenes strain FB188 HDAH by fluorescence anisotropyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM50293704(1,1,1-trifluoro-7-(1H-naphtho[2,3-d]imidazol-2-yl)...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of Atto700-HA from Bordetella / Alcaligenes strain FB188 HDAH by fluorescence anisotropyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM50293705(((2R,3S,4S,5R,6S)-6-((2R,3R,4S,5S,6R)-4,5-dihydrox...)
Affinity DataKi:  2.00E+3nMAssay Description:Binding affinity to Bordetella / Alcaligenes strain FB188 HDAC by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM50293702(11-(3-pentyloxiran-2-yl)undec-9-ynoic acid | CHEMB...)
Affinity DataKi:  4.30E+3nMAssay Description:Binding affinity to Bordetella / Alcaligenes strain FB188 HDAC by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM50293705(((2R,3S,4S,5R,6S)-6-((2R,3R,4S,5S,6R)-4,5-dihydrox...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of Bordetella / Alcaligenes strain FB188 HDAH by fluorogenic enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)
Affinity DataKi:  9.20E+3nMAssay Description:Displacement of Atto700-HA from Bordetella / Alcaligenes strain FB188 HDAH by fluorescence anisotropyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM50293702(11-(3-pentyloxiran-2-yl)undec-9-ynoic acid | CHEMB...)
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of Bordetella / Alcaligenes strain FB188 HDAH by fluorogenic enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM50293705(((2R,3S,4S,5R,6S)-6-((2R,3R,4S,5S,6R)-4,5-dihydrox...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of Atto700-HA from Bordetella / Alcaligenes strain FB188 HDAH by fluorescence anisotropyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM50293702(11-(3-pentyloxiran-2-yl)undec-9-ynoic acid | CHEMB...)
Affinity DataKi:  2.00E+4nMAssay Description:Displacement of Atto700-HA from Bordetella / Alcaligenes strain FB188 HDAH by fluorescence anisotropyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of Atto700-HA from Bordetella / Alcaligenes strain FB188 HDAH by fluorescence anisotropyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataIC50: 1.18E+5nMAssay Description:Inhibition of Bordetella / Alcaligenes strain FB188 HDAH by fluorogenic enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed