Compile Data Set for Download or QSAR
maximum 50k data
Found 45 Enz. Inhib. hit(s) with all data for entry = 50030369
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295219(2-(4-methyl-1,4-diazepane-1-carbonyl)pyrazolo[1,5-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295217(2-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]quinazoli...)
Affinity DataIC50:  30nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295218(2-(1,4-diazepane-1-carbonyl)pyrazolo[1,5-a]quinazo...)
Affinity DataIC50:  30nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295216(CHEMBL561717 | N-((1-methylpiperidin-4-yl)methyl)-...)
Affinity DataIC50:  70nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295215(CHEMBL550382 | N-((1-methylpyrrolidin-3-yl)methyl)...)
Affinity DataIC50:  80nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295214(CHEMBL559584 | N-(2-(1-morpholinocyclopentyl)ethyl...)
Affinity DataIC50:  90nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295211(2-phenylpyrazolo[1,5-a]quinazolin-5(4H)-one | CHEM...)
Affinity DataIC50:  100nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295212(2-(2,3-dimethoxyphenyl)pyrazolo[1,5-a]quinazolin-5...)
Affinity DataIC50:  100nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295213(CHEMBL550501 | N-(2-(dimethylamino)ethyl)-N-methyl...)
Affinity DataIC50:  100nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295209(CHEMBL550703 | N-(3-morpholinopropyl)-5-oxo-4,5-di...)
Affinity DataIC50:  140nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295210(CHEMBL563408 | N-(2-morpholinoethyl)-5-oxo-4,5-dih...)
Affinity DataIC50:  140nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295208(2-(thiophen-2-yl)pyrazolo[1,5-a]quinazolin-5(4H)-o...)
Affinity DataIC50:  150nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295175(2-(furan-2-yl)pyrazolo[1,5-a]quinazolin-5(4H)-one ...)
Affinity DataIC50:  200nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295178(2-cyclohexylpyrazolo[1,5-a]quinazolin-5(4H)-one | ...)
Affinity DataIC50:  200nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295177(2-(3,4-dimethoxyphenyl)pyrazolo[1,5-a]quinazolin-5...)
Affinity DataIC50:  200nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295176(2-(2,4-dimethoxyphenyl)pyrazolo[1,5-a]quinazolin-5...)
Affinity DataIC50:  200nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295181(2-methylpyrazolo[1,5-a]quinazolin-5(4H)-one | CHEM...)
Affinity DataIC50:  300nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295179(2-(4-(cyclopropylmethyl)piperazine-1-carbonyl)pyra...)
Affinity DataIC50:  300nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295180(2-(4-methylpiperazine-1-carbonyl)pyrazolo[1,5-a]qu...)
Affinity DataIC50:  300nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295182(2-isobutylpyrazolo[1,5-a]quinazolin-5(4H)-one | CH...)
Affinity DataIC50:  400nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295187(2-p-tolylpyrazolo[1,5-a]quinazolin-5(4H)-one | CHE...)
Affinity DataIC50:  500nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295186(2-(4-ethylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-o...)
Affinity DataIC50:  500nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295184(2-(4-chlorophenyl)pyrazolo[1,5-a]quinazolin-5(4H)-...)
Affinity DataIC50:  500nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295185(2-(3-chlorophenyl)pyrazolo[1,5-a]quinazolin-5(4H)-...)
Affinity DataIC50:  500nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295183((S)-2-(3-(octahydropyrrolo[1,2-a]pyrazine-2-carbon...)
Affinity DataIC50:  500nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295188((S)-2-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)...)
Affinity DataIC50:  600nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295189(2-(3-bromophenyl)pyrazolo[1,5-a]quinazolin-5(4H)-o...)
Affinity DataIC50:  600nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295190(2-(3-(morpholinomethyl)piperidine-1-carbonyl)pyraz...)
Affinity DataIC50:  700nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295191(2-(4-bromophenyl)pyrazolo[1,5-a]quinazolin-5(4H)-o...)
Affinity DataIC50:  700nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295192(CHEMBL552319 | N-(2-(dimethylamino)ethyl)-N-methyl...)
Affinity DataIC50:  800nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295193(CHEMBL562116 | N-(2-morpholinoethyl)-5-oxo-4,5-dih...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295197(2-(3-(4-methylpiperazine-1-carbonyl)phenyl)pyrazol...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295195(3-(4-methyl-1,4-diazepane-1-carbonyl)pyrazolo[1,5-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295196(3-(4-methylpiperazine-1-carbonyl)pyrazolo[1,5-a]qu...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295207(2-(4-propylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295206(2-(4-tert-butylphenyl)pyrazolo[1,5-a]quinazolin-5(...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295205(2-(3-fluorophenyl)pyrazolo[1,5-a]quinazolin-5(4H)-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295204(2-(4-fluorophenyl)pyrazolo[1,5-a]quinazolin-5(4H)-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295203(2-(4-(trifluoromethoxy)phenyl)pyrazolo[1,5-a]quina...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295202(4-(5-oxo-4,5-dihydropyrazolo[1,5-a]quinazolin-2-yl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295194(3-(1,4-diazepane-1-carbonyl)pyrazolo[1,5-a]quinazo...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295198(2-(4-(morpholinomethyl)piperidine-1-carbonyl)pyraz...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295199(CHEMBL557913 | N-(2-(dimethylamino)ethyl)-N-methyl...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295200(2-(4-(4-methylpiperazine-1-carbonyl)phenyl)pyrazol...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295201((S)-2-(4-(octahydropyrrolo[1,2-a]pyrazine-2-carbon...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed