Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50030370
TargetHistamine H3 receptor(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM22541(VUF 9153 | N''-[(4-chlorophenyl)methyl]{[3-(1H-imi...)
Affinity DataKi:  0.600nMAssay Description:Displacement of 3-([1,1,1-3H]methyl)-2-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone from mouse histamine H3 receptor expressed in HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM22541(VUF 9153 | N''-[(4-chlorophenyl)methyl]{[3-(1H-imi...)
Affinity DataEC50:  1.70nMAssay Description:Inverse agonist activity at mouse histamine H3 receptor overexpressed in HEK293 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM22911(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Affinity DataKi:  2nMAssay Description:Displacement of 3-([1,1,1-3H]methyl)-2-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone from mouse histamine H3 receptor expressed in HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistamine H3 receptor(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50246289(CHEMBL488248 | CHEMBL557214 | 3-methyl-2-(4-(3-(py...)
Affinity DataKi:  2.40nMAssay Description:Displacement of 3-([1,1,1-3H]methyl)-2-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone from mouse histamine H3 receptor expressed in HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50246289(CHEMBL488248 | CHEMBL557214 | 3-methyl-2-(4-(3-(py...)
Affinity DataKd:  2.60nMAssay Description:Binding affinity to mouse histamine H3 receptor overexpressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50246289(CHEMBL488248 | CHEMBL557214 | 3-methyl-2-(4-(3-(py...)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to histamine H3 receptor in wild type mouse brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50246289(CHEMBL488248 | CHEMBL557214 | 3-methyl-2-(4-(3-(py...)
Affinity DataKi:  4.20nMAssay Description:Binding affinity to human histamine H3 receptor by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi:  4.80nMAssay Description:Displacement of 3-([1,1,1-3H]methyl)-2-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone from mouse histamine H3 receptor expressed in HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50246289(CHEMBL488248 | CHEMBL557214 | 3-methyl-2-(4-(3-(py...)
Affinity DataEC50:  9.60nMAssay Description:Inverse agonist activity at mouse histamine H3 receptor overexpressed in HEK293 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataEC50:  11nMAssay Description:Inverse agonist activity at mouse histamine H3 receptor overexpressed in HEK293 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50246289(CHEMBL488248 | CHEMBL557214 | 3-methyl-2-(4-(3-(py...)
Affinity DataKi:  12nMAssay Description:Binding affinity to rat histamine H3 receptor by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  19nMAssay Description:Displacement of 3-([1,1,1-3H]methyl)-2-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone from mouse histamine H3 receptor expressed in HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM7966([3H]histamine | 2-(1H-imidazol-4-yl)ethan-1-amine ...)
Affinity DataKi:  68nMAssay Description:Displacement of 3-([1,1,1-3H]methyl)-2-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone from mouse histamine H3 receptor expressed in HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50246289(CHEMBL488248 | CHEMBL557214 | 3-methyl-2-(4-(3-(py...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50246289(CHEMBL488248 | CHEMBL557214 | 3-methyl-2-(4-(3-(py...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50246289(CHEMBL488248 | CHEMBL557214 | 3-methyl-2-(4-(3-(py...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed