Compile Data Set for Download or QSAR
maximum 50k data
Found 31 Enz. Inhib. hit(s) with all data for entry = 50030469
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29986(arylpyrazole, 31)
Affinity DataIC50:  0.310nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29986(arylpyrazole, 31)
Affinity DataIC50:  0.520nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296580((1S,3R)-3-fluoro-N-((5-(5-fluoro-6-methylpyridin-3...)
Affinity DataIC50:  0.610nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296581((1S,3R)-N-((1-ethyl-5-(5-fluoro-6-methylpyridin-3-...)
Affinity DataIC50:  0.610nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296580((1S,3R)-3-fluoro-N-((5-(5-fluoro-6-methylpyridin-3...)
Affinity DataIC50:  0.920nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296590((1S,3R)-N-((5-(3,5-difluorophenyl)-4-(methoxymethy...)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296590((1S,3R)-N-((5-(3,5-difluorophenyl)-4-(methoxymethy...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296581((1S,3R)-N-((1-ethyl-5-(5-fluoro-6-methylpyridin-3-...)
Affinity DataIC50:  2nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296582((1S,3R)-3-fluoro-N-((5-(5-fluoro-6-methylpyridin-3...)
Affinity DataIC50:  2.20nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296586((1S,3R)-N-((5-(3,5-difluorophenyl)-1,4-dimethyl-1H...)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296589((1S,3R)-N-((4-chloro-5-(3,5-difluorophenyl)-1-meth...)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296586((1S,3R)-N-((5-(3,5-difluorophenyl)-1,4-dimethyl-1H...)
Affinity DataIC50:  3.10nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296582((1S,3R)-3-fluoro-N-((5-(5-fluoro-6-methylpyridin-3...)
Affinity DataIC50:  4.30nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296579(3-[5-(3,5-difluorophenyl)-3-({[(1S,3R)-3-fluorocyc...)
Affinity DataIC50:  4.60nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296584((1S,3R)-N-((5-(3,4-difluorophenyl)-1,4-dimethyl-1H...)
Affinity DataIC50:  6.40nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296584((1S,3R)-N-((5-(3,4-difluorophenyl)-1,4-dimethyl-1H...)
Affinity DataIC50:  6.5nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296583((1S,3R)-3-fluoro-N-((5-(5-fluoro-6-methylpyridin-3...)
Affinity DataIC50:  7.80nMAssay Description:Antagonist activity at ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296579(3-[5-(3,5-difluorophenyl)-3-({[(1S,3R)-3-fluorocyc...)
Affinity DataIC50:  8.20nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296589((1S,3R)-N-((4-chloro-5-(3,5-difluorophenyl)-1-meth...)
Affinity DataIC50:  9.30nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296583((1S,3R)-3-fluoro-N-((5-(5-fluoro-6-methylpyridin-3...)
Affinity DataIC50:  9.90nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296592(1-(5-(3,5-difluorophenyl)-3-(((1S,3R)-3-fluorocycl...)
Affinity DataIC50:  12nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296585((1S,3R)-N-((1,4-dimethyl-5-(3,4,5-trifluorophenyl)...)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296593(2-(5-(3,5-difluorophenyl)-3-(((1S,3R)-3-fluorocycl...)
Affinity DataIC50:  15nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296585((1S,3R)-N-((1,4-dimethyl-5-(3,4,5-trifluorophenyl)...)
Affinity DataIC50:  15nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296587((1S,3R)-N-((5-(3-chloro-5-fluorophenyl)-1,4-dimeth...)
Affinity DataIC50:  17nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296591((1S,3R)-N-((5-(3,5-difluorophenyl)-4-methyl-1-(2-(...)
Affinity DataIC50:  33nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296588((1S,3R)-3-fluoro-N-((5-(3-fluoro-5-(trifluoromethy...)
Affinity DataIC50:  210nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296579(3-[5-(3,5-difluorophenyl)-3-({[(1S,3R)-3-fluorocyc...)
Affinity DataIC50:  9.50E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cells overexpressing Ikr channel proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296579(3-[5-(3,5-difluorophenyl)-3-({[(1S,3R)-3-fluorocyc...)
Affinity DataIC50:  9.80E+3nMAssay Description:Displacement of [3H]U69593 from human cloned kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296579(3-[5-(3,5-difluorophenyl)-3-({[(1S,3R)-3-fluorocyc...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]naltrindole from human cloned delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296579(3-[5-(3,5-difluorophenyl)-3-({[(1S,3R)-3-fluorocyc...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]diprenorphin from human cloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed