Compile Data Set for Download or QSAR
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Found 41 Enz. Inhib. hit(s) with all data for entry = 50038898
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296352(1-(8-(3-(4-methylpiperazin-1-yl)cyclobutyl)-2-phen...)
Affinity DataIC50:  19nMAssay Description:Inhibition of IGF1R by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296353(1-(8-(3-(aziridin-1-yl)cyclobutyl)-2-phenylquinoli...)
Affinity DataIC50:  20nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296355(CHEMBL553443 | N-(2-(5-(3,5-difluorophenylsulfonyl...)
Affinity DataIC50:  49nMAssay Description:Inhibition of human GST-tagged IGF1R by trans-phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296350((S)-3-(4-(2-(4-(2-(2-chlorophenyl)-2-hydroxyethyla...)
Affinity DataIC50:  51nMAssay Description:Inhibition of insulin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM4293((2E)-3-(3,4-dihydroxyphenyl)-2-[(3,4-dihydroxyphen...)
Affinity DataIC50:  61nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296350((S)-3-(4-(2-(4-(2-(2-chlorophenyl)-2-hydroxyethyla...)
Affinity DataIC50:  68nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM27879(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)
Affinity DataIC50:  73nMAssay Description:Inhibition of insulin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296355(CHEMBL553443 | N-(2-(5-(3,5-difluorophenylsulfonyl...)
Affinity DataIC50:  80nMAssay Description:Inhibition of IGF1R in human MCF7 cells by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-(benzyloxy)ph...)
Affinity DataIC50:  86nMAssay Description:Inhibition of IGF1R by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296356(CHEMBL541762 | N-(5-(5-(3,5-difluorophenylsulfonyl...)
Affinity DataIC50:  90nMAssay Description:Inhibition of GST-tagged human IGF1R expressed in baculovirus-infected Sf21 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296350((S)-3-(4-(2-(4-(2-(2-chlorophenyl)-2-hydroxyethyla...)
Affinity DataIC50:  94nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM27879(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-(benzyloxy)ph...)
Affinity DataIC50:  140nMAssay Description:Inhibition of insulin receptor-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Mus musculus)
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-(benzyloxy)ph...)
Affinity DataIC50:  150nMAssay Description:Inhibition of IGF1R-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM27879(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)
Affinity DataIC50:  150nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296357(4,4'-(benzo[d][1,3]dioxol-5-ylazanediyl)bis(methyl...)
Affinity DataIC50:  170nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296347(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-yl)cycl...)
Affinity DataIC50:  170nMAssay Description:Inhibition of IGF1R by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296356(CHEMBL541762 | N-(5-(5-(3,5-difluorophenylsulfonyl...)
Affinity DataIC50:  300nMAssay Description:Inhibition of IGF1R in IGF1-stimulated human MCF7 cells by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296354(CHEMBL549369 | N-(5-(3,5-difluorophenylsulfonyl)-4...)
Affinity DataIC50:  340nMAssay Description:Inhibition of IGF1R in growth factor-stimulated NHDFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM27879(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)
Affinity DataIC50:  341nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296351((R)-4-(2-(2-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50:  830nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50230005(1-(5-chloro-2-methoxyphenyl)-3-(2-methylquinolin-4...)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of IGF1R in growth factor-stimulated NHDFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296350((S)-3-(4-(2-(4-(2-(2-chlorophenyl)-2-hydroxyethyla...)
Affinity DataIC50: >1.50E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-(benzyloxy)ph...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of insulin receptor by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296347(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-yl)cycl...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of insulin receptor by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296354(CHEMBL549369 | N-(5-(3,5-difluorophenylsulfonyl)-4...)
Affinity DataIC50:  3.05E+3nMAssay Description:Inhibition for IGF1R-induced S6 ribosomal protein phosphorylation in growth factor-stimulated NHDFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50201127(3-(5-(1H-imidazol-1-yl)-7-methyl-1H-benzo[d]imidaz...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-(benzyloxy)ph...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of c-KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296347(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-yl)cycl...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of c-KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Mus musculus)
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50271906(2-benzyl-N4-(3-bromophenyl)-1H-indole-4,6-diamine ...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of IGF1R-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Mus musculus)
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50271907(2-(2-chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,...)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of IGF1R-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296347(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-yl)cycl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BCR-ABL p210More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-(benzyloxy)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BCR-ABL p210More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296347(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-yl)cycl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-(benzyloxy)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HER1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296347(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-yl)cycl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50230005(1-(5-chloro-2-methoxyphenyl)-3-(2-methylquinolin-4...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of IGF1R autophosphorylation in human MCF7 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50210252((2R,3R)-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50271906(2-benzyl-N4-(3-bromophenyl)-1H-indole-4,6-diamine ...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of insulin receptor-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50271907(2-(2-chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of insulin receptor-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50201141(3-(5-(1H-imidazol-1-yl)-7-methyl-1H-benzo[d]imidaz...)
Affinity DataIC50:  1.80E+5nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed