Compile Data Set for Download or QSAR
Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 3409
TargetGenome polyprotein [1394-1440]/[1476-1660,T1585M](Dengue virus 3 (strain S221/03))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33256(phthalazine-based compound, 7)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33252(phthalazine-based compound, 3)
Affinity DataIC50: 1.10E+3nM Kd:  7.70E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660](Dengue virus 4 (H241))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33256(phthalazine-based compound, 7)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660](Dengue virus 4 (H241))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33259(Bz-Nle-Lys-Arg-Arg-H | CHEMBL256877 | Bz-NKRR-H)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660,T1585M](Dengue virus 3 (strain S221/03))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33251(phthalazine-based compound, 2)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33256(phthalazine-based compound, 7)
Affinity DataIC50: 1.60E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33251(phthalazine-based compound, 2)
Affinity DataIC50: 2.00E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660](Dengue virus 4 (H241))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33251(phthalazine-based compound, 2)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](WNV)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33256(phthalazine-based compound, 7)
Affinity DataIC50: 2.20E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33251(phthalazine-based compound, 2)
Affinity DataIC50: 2.30E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33256(phthalazine-based compound, 7)
Affinity DataIC50: 2.72E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](WNV)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33251(phthalazine-based compound, 2)
Affinity DataIC50: 3.60E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](WNV)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33253(phthalazine-based compound, 4)
Affinity DataIC50: 5.20E+3nM Kd:  4.60E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33254(phthalazine-based compound, 5)
Affinity DataIC50: 5.80E+3nM Kd:  1.86E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33250(phthalazine-based compound, 1)
Affinity DataIC50: 6.00E+3nM Kd:  7.20E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](WNV)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33255(phthalazine-based compound, 6)
Affinity DataIC50: 6.20E+3nM Kd:  7.00E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660,T1585M](Dengue virus 3 (strain S221/03))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33259(Bz-Nle-Lys-Arg-Arg-H | CHEMBL256877 | Bz-NKRR-H)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660](Dengue virus 4 (H241))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33254(phthalazine-based compound, 5)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660,T1585M](Dengue virus 3 (strain S221/03))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33252(phthalazine-based compound, 3)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660,T1585M](Dengue virus 3 (strain S221/03))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33254(phthalazine-based compound, 5)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33259(Bz-Nle-Lys-Arg-Arg-H | CHEMBL256877 | Bz-NKRR-H)
Affinity DataIC50: 8.90E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33257(phthalazine-based compound, 8)
Affinity DataIC50: 1.02E+4nM Kd:  1.63E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](WNV)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33254(phthalazine-based compound, 5)
Affinity DataIC50: 1.06E+4nM Kd:  1.00E+5nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33252(phthalazine-based compound, 3)
Affinity DataIC50: 1.07E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33259(Bz-Nle-Lys-Arg-Arg-H | CHEMBL256877 | Bz-NKRR-H)
Affinity DataIC50: 1.18E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33254(phthalazine-based compound, 5)
Affinity DataIC50: 1.23E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660](Dengue virus 4 (H241))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33252(phthalazine-based compound, 3)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](WNV)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33257(phthalazine-based compound, 8)
Affinity DataIC50: 1.60E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660,T1585M](Dengue virus 3 (strain S221/03))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33250(phthalazine-based compound, 1)
Affinity DataIC50: 1.75E+4nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660](Dengue virus 4 (H241))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33257(phthalazine-based compound, 8)
Affinity DataIC50: 1.98E+4nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](WNV)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33250(phthalazine-based compound, 1)
Affinity DataIC50: 2.45E+4nM Kd:  2.10E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33257(phthalazine-based compound, 8)
Affinity DataIC50: 2.14E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](WNV)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33252(phthalazine-based compound, 3)
Affinity DataIC50: 2.20E+4nM Kd:  9.00E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33253(phthalazine-based compound, 4)
Affinity DataIC50: 2.74E+4nM Kd:  2.29E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660,T1585M](Dengue virus 3 (strain S221/03))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33257(phthalazine-based compound, 8)
Affinity DataIC50: 2.79E+4nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660](Dengue virus 4 (H241))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33250(phthalazine-based compound, 1)
Affinity DataIC50: 3.28E+4nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33250(phthalazine-based compound, 1)
Affinity DataIC50: 3.64E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660](Dengue virus 4 (H241))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33255(phthalazine-based compound, 6)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33255(phthalazine-based compound, 6)
Affinity DataIC50: 5.50E+4nM Kd:  5.40E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660](Dengue virus 4 (H241))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33253(phthalazine-based compound, 4)
Affinity DataIC50: 6.48E+4nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660,T1585M](Dengue virus 3 (strain S221/03))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33255(phthalazine-based compound, 6)
Affinity DataIC50: 8.60E+4nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660](Dengue virus 4 (H241))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33258(phthalazine-based compound, 9)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660,T1585M](Dengue virus 3 (strain S221/03))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33253(phthalazine-based compound, 4)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33258(phthalazine-based compound, 9)
Affinity DataIC50: 1.00E+5nM Kd:  1.00E+5nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1394-1440]/[1476-1660,T1585M](Dengue virus 3 (strain S221/03))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33258(phthalazine-based compound, 9)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33258(phthalazine-based compound, 9)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33255(phthalazine-based compound, 6)
Affinity DataIC50: 1.70E+5nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33253(phthalazine-based compound, 4)
Affinity DataIC50: 2.33E+5nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed