Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50030806
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301754BDBM50301754(isopropyl 2-cyano-6-(3-fluorobenzoyl)-4,4-dimethyl...)
Affinity DataEC50:  2.5nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301755BDBM50301755(isopropyl 2-cyano-6-(4-fluorobenzoyl)-4,4-dimethyl...)
Affinity DataEC50:  5nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301753BDBM50301753(isopropyl 2-cyano-6-(3,4-difluorobenzoyl)-4,4-dime...)
Affinity DataEC50:  6.30nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301756BDBM50301756(isopropyl 2-cyano-6-(cyclohexanecarbonyl)-4,4-dime...)
Affinity DataEC50:  6.5nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301759BDBM50301759(isopropyl 2-cyano-4,4-dimethyl-6-(3-(trifluorometh...)
Affinity DataEC50:  8.5nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301758BDBM50301758(isopropyl 6-(3-chlorobenzoyl)-2-cyano-4,4-dimethyl...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28542BDBM28542(propan-2-yl 3-[(3,4-difluorophenyl)carbonyl]-1,1-d...)
Affinity DataEC50:  16nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301760BDBM50301760(isopropyl 2-cyano-4,4-dimethyl-6-(thiophene-2-carb...)
Affinity DataEC50:  16nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301757BDBM50301757(isopropyl 2-cyano-6-(4-cyanobenzoyl)-4,4-dimethyl-...)
Affinity DataEC50:  35nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301761BDBM50301761(isopropyl 2-cyano-6-(3,4-difluorobenzoyl)-4,4-dime...)
Affinity DataEC50:  280nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301763BDBM50301763(isopropyl 2-cyano-6-(4-fluorobenzoyl)-4,4-dimethyl...)
Affinity DataEC50:  640nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301762BDBM50301762(isopropyl 2-cyano-6-(3-fluorobenzoyl)-4,4-dimethyl...)
Affinity DataEC50:  1.30E+3nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301766BDBM50301766(isopropyl 6-(3-chlorobenzoyl)-2-cyano-4,4-dimethyl...)
Affinity DataEC50:  1.30E+3nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301764BDBM50301764(isopropyl 2-cyano-6-(cyclohexanecarbonyl)-4,4-dime...)
Affinity DataEC50:  1.90E+3nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301767BDBM50301767(isopropyl 2-cyano-4,4-dimethyl-6-(3-(trifluorometh...)
Affinity DataEC50:  2.70E+3nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301769BDBM50301769(isopropyl 2-cyano-4,4-dimethyl-6-(tetrahydro-2H-py...)
Affinity DataEC50:  3.30E+3nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301768BDBM50301768(isopropyl 6-(4-chlorobenzoyl)-2-cyano-4,4-dimethyl...)
Affinity DataEC50:  4.10E+3nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301765BDBM50301765(isopropyl 2-cyano-6-(4-cyanobenzoyl)-4,4-dimethyl-...)
Affinity DataEC50:  5.70E+3nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed