Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50031315
TargetSerine/threonine-protein kinase mTOR(Human)
Kudos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310989((5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholin...)
Affinity DataIC50: 100nMAssay Description:Inhibition of mTORC1 in human U87MG cells assessed as phosphorylated S6 ribosomal protein (Ser235/236) level after 2 hrs by Western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Kudos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310989((5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholin...)
Affinity DataIC50: 100nMAssay Description:Inhibition of mTORC1 in human U87MG cells assessed as phosphorylated S6 ribosomal protein (Ser235/236) level after 2 hrs by Western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Kudos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310989((5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholin...)
Affinity DataIC50: 150nMAssay Description:Inhibition of mTORC2 in human U87MG cells assessed as phosphorylated AKT (Ser473) level after 2 hrs by Western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50310989((5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholin...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition PI3K-delta-mediated PIP2 phosphorylation after 20 mins by alphascreen competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50310989((5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholin...)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition PI3K-alpha-mediated PIP2 phosphorylation after 20 mins by alphascreen competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Kudos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310989((5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DNA-PKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Kudos Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310989((5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ATRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50310989((5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholin...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition PI3K-gamma-mediated PIP2 phosphorylation after 20 mins by alphascreen competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50310989((5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholin...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition PI3K-beta-mediated PIP2 phosphorylation after 20 mins by alphascreen competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed