Compile Data Set for Download or QSAR
Report error Found 83 Enz. Inhib. hit(s) with all data for entry = 50038919
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302846BDBM50302846(benzyl 3-((2R,3S)-3-acetamido-4-(3,5-difluoropheny...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302862BDBM50302862(N-((2S,3R)-4-((R)-3-(3-tert-butylphenyl)-6-(hydrox...)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50378120BDBM50378120(CHEMBL609987)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50378121BDBM50378121(CHEMBL609988)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302863BDBM50302863(N-((2S,3R)-4-((3R,6S)-3-(3-tert-butylphenyl)-6-(hy...)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302843BDBM50302843(N-((2S,3R)-4-(4-(3-tert-butylphenyl)-2-oxopiperidi...)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302838BDBM50302838(N-((2S,3R)-4-(1-(3-(1H-pyrazol-1-yl)phenyl)cyclohe...)
Affinity DataIC50: 22nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302855BDBM50302855(N-((2S,3R)-4-(3-(3-tert-butylphenyl)-6-methylenepi...)
Affinity DataIC50: 22nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302857BDBM50302857(N-((2S,3R)-4-((3R,6S)-3-(3-tert-butylphenyl)-6-(me...)
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302852BDBM50302852(trans-N-((2S,3R)-4-(1-(3-tert-butylphenyl)-4-hydro...)
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302841BDBM50302841(N-((2S,3R)-4-(1-(3-tert-butylphenyl)cyclohexylamin...)
Affinity DataIC50: 25nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302858BDBM50302858(N-((2S,3R)-4-((3R,6R)-3-(3-tert-butylphenyl)-6-(tr...)
Affinity DataIC50: 28nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302858BDBM50302858(N-((2S,3R)-4-((3R,6R)-3-(3-tert-butylphenyl)-6-(tr...)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302853BDBM50302853(trans-N-((2S,3R)-4-(1-(3-tert-butylphenyl)-4-(hydr...)
Affinity DataIC50: 38nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302841BDBM50302841(N-((2S,3R)-4-(1-(3-tert-butylphenyl)cyclohexylamin...)
Affinity DataIC50: 47nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302849BDBM50302849(N-((2S,3R)-4-(3-(3-tert-butylphenyl)-6-oxopiperidi...)
Affinity DataIC50: 47nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302855BDBM50302855(N-((2S,3R)-4-(3-(3-tert-butylphenyl)-6-methylenepi...)
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302856BDBM50302856(N-((2S,3R)-4-((3R,6S)-3-(3-tert-butylphenyl)-6-met...)
Affinity DataIC50: 49nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302838BDBM50302838(N-((2S,3R)-4-(1-(3-(1H-pyrazol-1-yl)phenyl)cyclohe...)
Affinity DataIC50: 59nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302839BDBM50302839(N-((2S,3R)-4-(4-(3-tert-butylphenyl)tetrahydro-2H-...)
Affinity DataIC50: 61nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302870BDBM50302870(N-((2S,3R)-4-((3R,6S)-3-(3-tert-butylphenyl)-6-(py...)
Affinity DataIC50: 73nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302856BDBM50302856(N-((2S,3R)-4-((3R,6S)-3-(3-tert-butylphenyl)-6-met...)
Affinity DataIC50: 80nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302857BDBM50302857(N-((2S,3R)-4-((3R,6S)-3-(3-tert-butylphenyl)-6-(me...)
Affinity DataIC50: 84nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302871BDBM50302871(N-((2S,3R)-4-((3R,6S)-3-(3-tert-butylphenyl)-6-(th...)
Affinity DataIC50: 85nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302848BDBM50302848(3-((2R,3S)-3-acetamido-4-(3,5-difluorophenyl)-2-hy...)
Affinity DataIC50: 90nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50378122BDBM50378122(CHEMBL1163020)
Affinity DataIC50: 93nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302864BDBM50302864(N-((2S,3R)-4-((3R,6S)-3-(3-tert-butylphenyl)-6-(me...)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302850BDBM50302850(N-((2S,3R)-4-(1-(3-tert-butylphenyl)-4-oxocyclohex...)
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302840BDBM50302840(N-((2S,3R)-4-(1-(3-tert-butylphenyl)cyclopentylami...)
Affinity DataIC50: 130nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302859BDBM50302859(N-((2S,3R)-4-((3R,6S)-3-(3-tert-butylphenyl)-6-met...)
Affinity DataIC50: 130nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302859BDBM50302859(N-((2S,3R)-4-((3R,6S)-3-(3-tert-butylphenyl)-6-met...)
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302837BDBM50302837(N-((2S,3R)-4-(3-(3-(1H-pyrazol-1-yl)phenyl)tetrahy...)
Affinity DataIC50: 170nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302849BDBM50302849(N-((2S,3R)-4-(3-(3-tert-butylphenyl)-6-oxopiperidi...)
Affinity DataIC50: 180nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302866BDBM50302866(N-((2S,3R)-4-((3R,6S)-3-(3-tert-butylphenyl)-6-for...)
Affinity DataIC50: 210nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50378121BDBM50378121(CHEMBL609988)
Affinity DataIC50: 210nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302861BDBM50302861(N-((2S,3R)-4-((3R,6S)-3-(3-tert-butylphenyl)-6-(me...)
Affinity DataIC50: 210nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302840BDBM50302840(N-((2S,3R)-4-(1-(3-tert-butylphenyl)cyclopentylami...)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302839BDBM50302839(N-((2S,3R)-4-(4-(3-tert-butylphenyl)tetrahydro-2H-...)
Affinity DataIC50: 230nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302868BDBM50302868(N-((2S,5R)-5-((2R,3S)-3-acetamido-4-(3,5-difluorop...)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302865BDBM50302865(methyl(2S,5R)-5-((2R,3S)-3-acetamido-4-(3,5-difluo...)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302837BDBM50302837(N-((2S,3R)-4-(3-(3-(1H-pyrazol-1-yl)phenyl)tetrahy...)
Affinity DataIC50: 270nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50378120BDBM50378120(CHEMBL609987)
Affinity DataIC50: 300nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302848BDBM50302848(3-((2R,3S)-3-acetamido-4-(3,5-difluorophenyl)-2-hy...)
Affinity DataIC50: 330nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302853BDBM50302853(trans-N-((2S,3R)-4-(1-(3-tert-butylphenyl)-4-(hydr...)
Affinity DataIC50: 330nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302843BDBM50302843(N-((2S,3R)-4-(4-(3-tert-butylphenyl)-2-oxopiperidi...)
Affinity DataIC50: 330nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302843BDBM50302843(N-((2S,3R)-4-(4-(3-tert-butylphenyl)-2-oxopiperidi...)
Affinity DataIC50: 330nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302869BDBM50302869(N-((2S,3R)-4-((3R,6S)-6-acetamido-3-(3-tert-butylp...)
Affinity DataIC50: 350nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302860BDBM50302860(N-((2S,3R)-4-((3R,6R)-3-(3-tert-butylphenyl)-6-cya...)
Affinity DataIC50: 380nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302842BDBM50302842(4-((2R,3S)-3-acetamido-4-( 3,5-difluorophenyl)-2-h...)
Affinity DataIC50: 380nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302867BDBM50302867(N-((2S,3R)-4-((3R,6S)-3-(3-tert-butylphenyl)-6-(me...)
Affinity DataIC50: 400nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
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