Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50031349
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311713BDBM50311713(SR-6494 | N-(2-(dimethylamino)ethyl)-N-(3-methoxyb...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311728BDBM50311728(SR-6074 | 3-(6-(1H-pyrazol-4-yl)benzo[d]thiazol-2-...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311728BDBM50311728(SR-6074 | 3-(6-(1H-pyrazol-4-yl)benzo[d]thiazol-2-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311713BDBM50311713(SR-6494 | N-(2-(dimethylamino)ethyl)-N-(3-methoxyb...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311724BDBM50311724(3-(6-(1H-pyrazol-4-yl)benzo[d]thiazol-2-yl)-N-(2-(...)
Affinity DataIC50: 7nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311714BDBM50311714(4-(2-(chroman-3-yl)benzo[d]thiazol-6-yl)pyrimidin-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311727BDBM50311727(N-(3-methoxybenzyl)-N-(2-methoxyethyl)-6-(1H-pyraz...)
Affinity DataIC50: 10nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311715BDBM50311715(2-(chroman-3-yl)-6-(1H-pyrazol-4-yl)benzo[d]thiazo...)
Affinity DataIC50: 11nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311717BDBM50311717(2-(chroman-3-yl)-4-fluoro-6-(1H-pyrazol-4-yl)benzo...)
Affinity DataIC50: 14nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311725BDBM50311725(N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)benzo[d]thi...)
Affinity DataIC50: 18nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311731BDBM50311731(2-(chroman-3-yl)-6-(3-methyl-1H-pyrazol-4-yl)benzo...)
Affinity DataIC50: 25nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311726BDBM50311726(N-ethyl-N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)ben...)
Affinity DataIC50: 26nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311718BDBM50311718(2-(chroman-3-yl)-4-methoxy-6-(1H-pyrazol-4-yl)benz...)
Affinity DataIC50: 32nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311722BDBM50311722(2-(6-fluorochroman-3-yl)-6-(1H-pyrazol-4-yl)benzo[...)
Affinity DataIC50: 38nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311729BDBM50311729(2-(chroman-3-yl)-6-(pyridin-4-yl)benzo[d]thiazole ...)
Affinity DataIC50: 42nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311721BDBM50311721(2-(6-methoxychroman-3-yl)-6-(1H-pyrazol-4-yl)benzo...)
Affinity DataIC50: 45nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311716BDBM50311716(2-(chroman-3-yl)-5-fluoro-6-(1H-pyrazol-4-yl)benzo...)
Affinity DataIC50: 47nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311720BDBM50311720(N1-(2-(chroman-3-yl)-6-(1H-pyrazol-4-yl)benzo[d]th...)
Affinity DataIC50: 51nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311736BDBM50311736(N-benzyl-6-(1H-pyrazol-4-yl)benzo[d]thiazole-2-car...)
Affinity DataIC50: 53nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311738BDBM50311738(N-(3-methoxybenzyl)-N-methyl-6-(1H-pyrazol-4-yl)be...)
Affinity DataIC50: 59nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311723BDBM50311723(methyl 3-(6-(1H-pyrazol-4-yl)benzo[d]thiazol-2-yl)...)
Affinity DataIC50: 59nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311719BDBM50311719(2-(2-(chroman-3-yl)-6-(1H-pyrazol-4-yl)benzo[d]thi...)
Affinity DataIC50: 66nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311737BDBM50311737(N-(3-fluorobenzyl)-6-(1H-pyrazol-4-yl)benzo[d]thia...)
Affinity DataIC50: 72nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311735BDBM50311735(2-(6-chlorochroman-3-yl)-6-(1H-pyrazol-4-yl)benzo[...)
Affinity DataIC50: 75nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311734BDBM50311734(2-(6-methylchroman-3-yl)-6-(1H-pyrazol-4-yl)benzo[...)
Affinity DataIC50: 93nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311739BDBM50311739(N-cyclopropyl-N-(3-methoxybenzyl)-6-(1H-pyrazol-4-...)
Affinity DataIC50: 94nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311726BDBM50311726(N-ethyl-N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)ben...)
Affinity DataIC50: 180nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase MRCK alpha(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311713BDBM50311713(SR-6494 | N-(2-(dimethylamino)ethyl)-N-(3-methoxyb...)
Affinity DataIC50: 247nMAssay Description:Inhibition of MRCKalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311732BDBM50311732(4-(2-(2-(chroman-3-yl)-6-(1H-pyrazol-4-yl)benzo[d]...)
Affinity DataIC50: 314nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311733BDBM50311733(2-(chroman-3-yl)-6-(1H-pyrazol-4-yl)-4-(2-(tetrahy...)
Affinity DataIC50: 500nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311730BDBM50311730(2-(chroman-3-yl)-6-(2-methylpyridin-4-yl)benzo[d]t...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311728BDBM50311728(SR-6074 | 3-(6-(1H-pyrazol-4-yl)benzo[d]thiazol-2-...)
Affinity DataIC50: 5.46E+3nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase MRCK alpha(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311726BDBM50311726(N-ethyl-N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)ben...)
Affinity DataIC50: 7.86E+3nMAssay Description:Inhibition of MRCKalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase MRCK alpha(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311728BDBM50311728(SR-6074 | 3-(6-(1H-pyrazol-4-yl)benzo[d]thiazol-2-...)
Affinity DataIC50: 9.55E+3nMAssay Description:Inhibition of MRCKalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311713BDBM50311713(SR-6494 | N-(2-(dimethylamino)ethyl)-N-(3-methoxyb...)
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Translational Research Institute and Department of Molecular Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311726BDBM50311726(N-ethyl-N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)ben...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed