Compile Data Set for Download or QSAR
Report error Found 45 Enz. Inhib. hit(s) with all data for entry = 50031367
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312070(N-(3-(3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312058(N-(3-(3-(4-(pyrrolidin-1-ylmethyl)phenyl)pyrazolo[...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[...)
Affinity DataIC50: 25nMAssay Description:Inhibition of cRAFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312054(N-(3-(3-(4-(2-(dimethylamino)ethyl)phenyl)pyrazolo...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312073(N-(4-fluoro-3-(3-(6-(4-methylpiperazin-1-yl)pyridi...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312062(N-(3-(3-(6-(2-(dimethylamino)ethylamino)pyridin-3-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312050(N-(3-(3-(4-(2-(dimethylamino)acetamido)phenyl)pyra...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312059(N-(3-(3-(4-((4-methylpiperazin-1-yl)methyl)phenyl)...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312051(N-(3-(3-(3-(2-(dimethylamino)acetamido)phenyl)pyra...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312053(N-(3-(3-(3-(2-(dimethylamino)ethyl)phenyl)pyrazolo...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312071(N-(3-(3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Affinity DataIC50: 42nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312056(N-(3-(3-(3-((dimethylamino)methyl)phenyl)pyrazolo[...)
Affinity DataIC50: 44nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312063(N-(3-(3-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)py...)
Affinity DataIC50: 44nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312048(N-(3-(3-(3-carbamoylphenyl)pyrazolo[1,5-a]pyrimidi...)
Affinity DataIC50: 57nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312065(N-(3-(3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Affinity DataIC50: 84nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312072(N-(3-(3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Affinity DataIC50: 98nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312061(N-(3-(3-(6-aminopyridin-3-yl)pyrazolo[1,5-a]pyrimi...)
Affinity DataIC50: 112nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312060(N-(3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-y...)
Affinity DataIC50: 113nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312055(N-(3-(3-(2-((dimethylamino)methyl)phenyl)pyrazolo[...)
Affinity DataIC50: 117nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312049(N-(3-(3-(4-(2-(2-methoxyethoxy)acetamido)phenyl)py...)
Affinity DataIC50: 139nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[...)
Affinity DataIC50: 216nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312069(N-(3-(3-(5-((4-ethylpiperazin-1-yl)methyl)furan-3-...)
Affinity DataIC50: 219nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312046(N-(3-(3-(4-(dimethylamino)phenyl)pyrazolo[1,5-a]py...)
Affinity DataIC50: 308nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312052(N-(3-(3-(2-(2-(dimethylamino)ethyl)phenyl)pyrazolo...)
Affinity DataIC50: 318nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312067(N-(3-(3-(furan-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)...)
Affinity DataIC50: 326nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312068(N-(3-(3-(5-(pyrrolidin-1-ylmethyl)furan-3-yl)pyraz...)
Affinity DataIC50: 362nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312066(N-(3-(3-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-pyrazol-4...)
Affinity DataIC50: 393nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312044(N-(3-(3-(5-morpholinopent-1-ynyl)pyrazolo[1,5-a]py...)
Affinity DataIC50: 552nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312045(N-(3-(3-(5-(4-methylpiperazin-1-yl)pent-1-ynyl)pyr...)
Affinity DataIC50: 842nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312064(N-(3-(3-(2-morpholinopyrimidin-5-yl)pyrazolo[1,5-a...)
Affinity DataIC50: 941nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294451(ethyl 7-(3-(3-(trifluoromethyl)benzamido)phenyl)py...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312057(N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312057(N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312057(N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312057(N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of MKK6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312047(N-(3-(3-(4-(N,N-dimethylsulfamoyl)phenyl)pyrazolo[...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed