Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50031373
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312221(N-Benzyloxycarbonylamino-L-alanine-2S-pyrrolidine-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of prolyl oligopeptidase in human LN229 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312221(N-Benzyloxycarbonylamino-L-alanine-2S-pyrrolidine-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of prolyl oligopeptidase in human LNZ308 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312221(N-Benzyloxycarbonylamino-L-alanine-2S-pyrrolidine-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of prolyl oligopeptidase in human HCEC cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312221(N-Benzyloxycarbonylamino-L-alanine-2S-pyrrolidine-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of prolyl oligopeptidase in intact human HCEC cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312222(N-Benzyloxycarbonylamino-glycine-2S-pyrrolidine-2-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of prolyl oligopeptidase in human LNZ308 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312222(N-Benzyloxycarbonylamino-glycine-2S-pyrrolidine-2-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of prolyl oligopeptidase in human LN229 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312221(N-Benzyloxycarbonylamino-L-alanine-2S-pyrrolidine-...)
Affinity DataIC50: 28nMAssay Description:Inhibition of prolyl oligopeptidase in intact human LN229 cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312221(N-Benzyloxycarbonylamino-L-alanine-2S-pyrrolidine-...)
Affinity DataIC50: 29nMAssay Description:Inhibition of prolyl oligopeptidase in intact human LNZ308 cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312222(N-Benzyloxycarbonylamino-glycine-2S-pyrrolidine-2-...)
Affinity DataIC50: 95nMAssay Description:Inhibition of prolyl oligopeptidase in human HCEC cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312222(N-Benzyloxycarbonylamino-glycine-2S-pyrrolidine-2-...)
Affinity DataIC50: 180nMAssay Description:Inhibition of prolyl oligopeptidase in intact human HCEC cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of prolyl oligopeptidase in human LNZ308 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312222(N-Benzyloxycarbonylamino-glycine-2S-pyrrolidine-2-...)
Affinity DataIC50: 325nMAssay Description:Inhibition of prolyl oligopeptidase in intact human LN229 cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312224(N-Benzyloxycarbonylamino-glycine-2R-pyrrolidine-2-...)
Affinity DataIC50: 430nMAssay Description:Inhibition of prolyl oligopeptidase in human LNZ308 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312224(N-Benzyloxycarbonylamino-glycine-2R-pyrrolidine-2-...)
Affinity DataIC50: 430nMAssay Description:Inhibition of prolyl oligopeptidase in human LN229 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50: 500nMAssay Description:Inhibition of prolyl oligopeptidase in human LN229 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312222(N-Benzyloxycarbonylamino-glycine-2S-pyrrolidine-2-...)
Affinity DataIC50: 590nMAssay Description:Inhibition of prolyl oligopeptidase in intact human LNZ308 cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312224(N-Benzyloxycarbonylamino-glycine-2R-pyrrolidine-2-...)
Affinity DataIC50: 690nMAssay Description:Inhibition of prolyl oligopeptidase in human HCEC cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50: 700nMAssay Description:Inhibition of prolyl oligopeptidase in human HCEC cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50415696(CHEMBL2021328)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of prolyl oligopeptidase in human LNZ308 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of prolyl oligopeptidase in intact human HCEC cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50415696(CHEMBL2021328)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of prolyl oligopeptidase in human LN229 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of prolyl oligopeptidase in intact human LN229 cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50415696(CHEMBL2021328)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of prolyl oligopeptidase in human HCEC cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of prolyl oligopeptidase in intact human LNZ308 cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312224(N-Benzyloxycarbonylamino-glycine-2R-pyrrolidine-2-...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of prolyl oligopeptidase in intact human HCEC cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312224(N-Benzyloxycarbonylamino-glycine-2R-pyrrolidine-2-...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of prolyl oligopeptidase in intact human LN229 cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312224(N-Benzyloxycarbonylamino-glycine-2R-pyrrolidine-2-...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of prolyl oligopeptidase in intact human LNZ308 cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50415696(CHEMBL2021328)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of prolyl oligopeptidase in intact human LNZ308 cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50415696(CHEMBL2021328)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of prolyl oligopeptidase in intact human HCEC cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50415696(CHEMBL2021328)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of prolyl oligopeptidase in intact human LN229 cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed