Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50030695
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(atropisomer 2 | atropisomer 1 | 10-(4-hydroxypheny...)
Affinity DataIC50: 270nMAssay Description:Inhibition of JAK2 in human TF1 cells assessed as inhibition of GMCSF-induced STAT5 phosphorylation by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(atropisomer 2 | atropisomer 1 | 10-(4-hydroxypheny...)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of JAK3 in human HT2 cells assessed as inhibition of IL2-induced STAT5 phosphorylation by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(atropisomer 2 | atropisomer 1 | 10-(4-hydroxypheny...)
Affinity DataKi:  0.00100nMAssay Description:Inhibition of recombinant JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(atropisomer 2 | atropisomer 1 | 10-(4-hydroxypheny...)
Affinity DataKi:  0.00500nMAssay Description:Inhibition of recombinant JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(atropisomer 2 | atropisomer 1 | 10-(4-hydroxypheny...)
Affinity DataKi:  0.00500nMAssay Description:Inhibition of recombinant JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(atropisomer 2 | atropisomer 1 | 10-(4-hydroxypheny...)
Affinity DataKi:  17nMAssay Description:Inhibition of ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(atropisomer 2 | atropisomer 1 | 10-(4-hydroxypheny...)
Affinity DataKi:  190nMAssay Description:Inhibition of cKitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300198(5-chloro-3-phenyl-1H-pyrrolo[2,3-b]pyridine | CHEM...)
Affinity DataKi:  260nMAssay Description:Inhibition of recombinant JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(atropisomer 2 | atropisomer 1 | 10-(4-hydroxypheny...)
Affinity DataKi:  340nMAssay Description:Inhibition of GCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300197(4-phenyl-7H-pyrrolo[2,3-d]pyrimidine | CHEMBL57897...)
Affinity DataKi:  480nMAssay Description:Inhibition of recombinant JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed