Compile Data Set for Download or QSAR
maximum 50k data
Found 35 Enz. Inhib. hit(s) with all data for entry = 50031215
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309081((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-(2H-tet...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309084((S)-2-((2S,4R)-4-(1H-benzo[d]imidazol-1-yl)-1-(3-c...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309092(2-(1-(1-(3-cyanophenylsulfonyl)-4-(2-methylpiperid...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309087((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-(piperi...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of human VLA4 in presence of 90% human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309092(2-(1-(1-(3-cyanophenylsulfonyl)-4-(2-methylpiperid...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of human VLA4 in presence of 90% human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309087((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-(piperi...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309091((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-thiomor...)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of human VLA4 in presence of 90% human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309090((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-morphol...)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of human VLA4 in presence of 90% human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309093(2-(1-(3-cyanophenylsulfonyl)-4-(3-methylpiperidin-...)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309093(2-(1-(3-cyanophenylsulfonyl)-4-(3-methylpiperidin-...)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of human VLA4 in presence of 90% human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309090((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-morphol...)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309091((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-thiomor...)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309095(2-(1-(3-cyanophenylsulfonyl)-4-(3,5-dimethylpiperi...)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309095(2-(1-(3-cyanophenylsulfonyl)-4-(3,5-dimethylpiperi...)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of human VLA4 in presence of 90% human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309096((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-(3,3-di...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309094((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-(4-meth...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309086((S)-2-((3'R,5'S)-1'-(3-cyanophenylsulfonyl)-1,3'-b...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309094((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-(4-meth...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of human VLA4 in presence of 90% human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309086((S)-2-((3'R,5'S)-1'-(3-cyanophenylsulfonyl)-1,3'-b...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of human VLA4 in presence of 90% human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309096((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-(3,3-di...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of human VLA4 in presence of 90% human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309078((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-(1H-pyr...)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309089((S)-2-((2S,4R)-4-(azocan-1-yl)-1-(3-cyanophenylsul...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309089((S)-2-((2S,4R)-4-(azocan-1-yl)-1-(3-cyanophenylsul...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of human VLA4 in presence of 90% human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309082((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-(1H-ind...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309085((S)-2-((2S,4R)-4-(azetidin-1-yl)-1-(3-cyanophenyls...)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of human VLA4 in presence of 90% human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309085((S)-2-((2S,4R)-4-(azetidin-1-yl)-1-(3-cyanophenyls...)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309083((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-(4,5,6,...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309088((S)-2-((2S,4R)-4-(azepan-1-yl)-1-(3-cyanophenylsul...)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of human VLA4 in presence of 90% human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309088((S)-2-((2S,4R)-4-(azepan-1-yl)-1-(3-cyanophenylsul...)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309078((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-(1H-pyr...)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of human VLA4 in presence of 90% human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309084((S)-2-((2S,4R)-4-(1H-benzo[d]imidazol-1-yl)-1-(3-c...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human VLA4 in presence of 90% human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309080((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-(1H-1,2...)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309079((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-(1H-imi...)
Affinity DataIC50:  0.810nMAssay Description:Inhibition of human VLA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309082((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-(1H-ind...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human VLA4 in presence of 90% human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309083((S)-2-((2S,4R)-1-(3-cyanophenylsulfonyl)-4-(4,5,6,...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human VLA4 in presence of 90% human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed