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Found 20 Enz. Inhib. hit(s) with all data for entry = 50031391
TargetCathepsin D(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312541(((S)-1-[(S)-1-[(1S,2S,4R)-4-((S)-1-Benzylcarbamoyl...)
Affinity DataIC50:  0.630nMAssay Description:Inhibition of human liver cathepsin D after 20 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312539(CHEMBL1076905 | N-[(1S,2S,4R)-4-((S)-1-Benzylcarba...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of BACE1 after 30 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312537(CHEMBL1076901 | N-[(1S,2S,4R)-4-((S)-1-Benzylcarba...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of BACE1 after 30 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312538(CHEMBL1076902 | N-[(1S,2S,4R)-4-((S)-1-Benzylcarba...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of BACE1 after 30 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312540(CHEMBL1076906 | N-[(1S,2S,4S)-4-((S)-1-Benzylcarba...)
Affinity DataIC50:  10nMAssay Description:Inhibition of BACE1 after 30 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312537(CHEMBL1076901 | N-[(1S,2S,4R)-4-((S)-1-Benzylcarba...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human liver cathepsin D after 20 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312539(CHEMBL1076905 | N-[(1S,2S,4R)-4-((S)-1-Benzylcarba...)
Affinity DataIC50:  59nMAssay Description:Inhibition of human liver cathepsin D after 20 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312540(CHEMBL1076906 | N-[(1S,2S,4S)-4-((S)-1-Benzylcarba...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human liver cathepsin D after 20 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312539(CHEMBL1076905 | N-[(1S,2S,4R)-4-((S)-1-Benzylcarba...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human BACE1 in HEK293 cells stably co-transfected with mutant APP(swAPP751) assessed as Amyloid beta 1-40 level after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312538(CHEMBL1076902 | N-[(1S,2S,4R)-4-((S)-1-Benzylcarba...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human liver cathepsin D after 20 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312540(CHEMBL1076906 | N-[(1S,2S,4S)-4-((S)-1-Benzylcarba...)
Affinity DataIC50:  340nMAssay Description:Inhibition of human BACE1 in HEK293 cells stably co-transfected with mutant APP(swAPP751) assessed as Amyloid beta 1-40 level after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312537(CHEMBL1076901 | N-[(1S,2S,4R)-4-((S)-1-Benzylcarba...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human BACE1 in HEK293 cells stably co-transfected with mutant APP(swAPP751) assessed as Amyloid beta 1-40 level after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312542(CHEMBL1076908 | N-[(1S,2S,4R)-4-((S)-1-Benzylcarba...)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of BACE1 after 30 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312544(CHEMBL1076910 | N-[(1S,2S,4R)-1-(3,5-Difluoro-benz...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of BACE1 after 30 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312538(CHEMBL1076902 | N-[(1S,2S,4R)-4-((S)-1-Benzylcarba...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of human BACE1 in HEK293 cells stably co-transfected with mutant APP(swAPP751) assessed as Amyloid beta 1-40 level after 24 hrs by ELISAMore data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312544(CHEMBL1076910 | N-[(1S,2S,4R)-1-(3,5-Difluoro-benz...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human liver cathepsin D after 20 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312542(CHEMBL1076908 | N-[(1S,2S,4R)-4-((S)-1-Benzylcarba...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human liver cathepsin D after 20 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312543(CHEMBL1076909 | N-((1S,2S,4R)-1-Benzyloxymethyl-4-...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human liver cathepsin D after 20 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312543(CHEMBL1076909 | N-((1S,2S,4R)-1-Benzyloxymethyl-4-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BACE1 after 30 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312541(((S)-1-[(S)-1-[(1S,2S,4R)-4-((S)-1-Benzylcarbamoyl...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of BACE1 after 30 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed