Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 50032052
TargetTransthyretin(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50323722(4-fluorophenyl 3-[(E)-2-(4-hydroxy-3,5-dimethylphe...)
Affinity DataIC50: 1.96E+3nMpH: 4.4Assay Description:Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50323725(S-phenyl 3-(3,5-dibromo-4-hydroxystyryl)benzothioa...)
Affinity DataIC50: 2.00E+3nMpH: 4.4Assay Description:Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetTransthyretin(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50323724(S-phenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzothio...)
Affinity DataIC50: 2.00E+3nMpH: 4.4Assay Description:Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetTransthyretin(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50323723(2-nitrophenyl 3-(4-hydroxy-3,5-dimethylstyryl)benz...)
Affinity DataIC50: 2.26E+3nMpH: 4.4Assay Description:Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetTransthyretin(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50012781(CHEMBL442167 | 3-[2-(4-Hydroxy-3,5-dimethyl-phenyl...)
Affinity DataIC50: 3.07E+3nMpH: 4.4Assay Description:Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetTransthyretin(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50012798((E)-2,6-dimethyl-4-styrylphenol | 2,6-dimethyl-4-s...)
Affinity DataIC50: 3.08E+3nMpH: 4.4Assay Description:Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)