Compile Data Set for Download or QSAR
Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 50031408
LigandPNGBDBM50312752((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)
Affinity DataIC50: 3nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312754((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312750((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)
Affinity DataIC50: 6nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312744((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312755((S)-3-(4-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312757((S)-3-(3,4-difluorophenyl)-N1-(5-(3-methyl-1H-inda...)
Affinity DataIC50: 14nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312754((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Affinity DataIC50: 17nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312765((S)-3-(3-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312756((S)-3-(2,4-dichlorophenyl)-N1-(5-(3-methyl-1H-inda...)
Affinity DataIC50: 18nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312765((S)-3-(3-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312757((S)-3-(3,4-difluorophenyl)-N1-(5-(3-methyl-1H-inda...)
Affinity DataIC50: 19nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312749((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)
Affinity DataIC50: 24nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312750((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)
Affinity DataIC50: 24nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312747((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)
Affinity DataIC50: 25nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312744((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Affinity DataIC50: 35nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312764((S)-3-(3-fluorophenyl)-N1-(5-(3-methyl-1H-indazol-...)
Affinity DataIC50: 38nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312751((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)
Affinity DataIC50: 40nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312749((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)
Affinity DataIC50: 41nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312762((S)-3-(2-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)
Affinity DataIC50: 47nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312752((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)
Affinity DataIC50: 53nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312762((S)-3-(2-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)
Affinity DataIC50: 57nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312756((S)-3-(2,4-dichlorophenyl)-N1-(5-(3-methyl-1H-inda...)
Affinity DataIC50: 70nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312755((S)-3-(4-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)
Affinity DataIC50: 72nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312759((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Affinity DataIC50: 72nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312748((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)
Affinity DataIC50: 74nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312759((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Affinity DataIC50: 76nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312746((S)-N1-(5-(3-phenyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Affinity DataIC50: 79nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312761((S)-3-(2-fluorophenyl)-N1-(5-(3-methyl-1H-indazol-...)
Affinity DataIC50: 104nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312745((S)-N1-(5-(3-cyclopropyl-1H-indazol-5-yl)-1,3,4-th...)
Affinity DataIC50: 135nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312750((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)
Affinity DataIC50: 154nMAssay Description:Inhibition of human AKT1 in human MDA-MB-468 cells assessed as phosphorylation-mediated nuclear translocation of GFP-tagged FKHRL1 by fluorescence mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312745((S)-N1-(5-(3-cyclopropyl-1H-indazol-5-yl)-1,3,4-th...)
Affinity DataIC50: 181nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312761((S)-3-(2-fluorophenyl)-N1-(5-(3-methyl-1H-indazol-...)
Affinity DataIC50: 198nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312763((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Affinity DataIC50: 198nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312752((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)
Affinity DataIC50: 247nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312753((S)-N1-(5-(3-methylisoquinolin-6-yl)-1,3,4-thiadia...)
Affinity DataIC50: 280nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312751((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)
Affinity DataIC50: 323nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312754((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Affinity DataIC50: 333nMAssay Description:Inhibition of human AKT1 in human MDA-MB-468 cells assessed as phosphorylation-mediated nuclear translocation of GFP-tagged FKHRL1 by fluorescence mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312754((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Affinity DataIC50: 357nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312748((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)
Affinity DataIC50: 368nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312758((S)-N1-(5-(3-ethyl-1H-indazol-5-yl)-1,3,4-thiadiaz...)
Affinity DataIC50: 370nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312746((S)-N1-(5-(3-phenyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Affinity DataIC50: 413nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312750((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)
Affinity DataIC50: 444nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312763((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Affinity DataIC50: 491nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312753((S)-N1-(5-(3-methylisoquinolin-6-yl)-1,3,4-thiadia...)
Affinity DataIC50: 607nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312752((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)
Affinity DataIC50: 695nMAssay Description:Inhibition of human AKT1 in human MDA-MB-468 cells assessed as phosphorylation-mediated nuclear translocation of GFP-tagged FKHRL1 by fluorescence mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312752((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of SGK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312760((R)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed