Compile Data Set for Download or QSAR
maximum 50k data
Found 42 Enz. Inhib. hit(s) with all data for entry = 50031132
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(CHEMBL602123 | N-(2,3,4-trifluoro-5-(2-oxo-2,3-dih...)
Affinity DataIC50:  3nMAssay Description:Inhibition of cRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(CHEMBL602123 | N-(2,3,4-trifluoro-5-(2-oxo-2,3-dih...)
Affinity DataIC50:  42nMAssay Description:Inhibition of wild type BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(CHEMBL598626 | N-(3-tert-butyl-1-phenyl-1H-pyrazol...)
Affinity DataIC50:  126nMAssay Description:Inhibition of cRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  152nMAssay Description:Inhibition of p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  196nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  198nMAssay Description:Inhibition of cRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(CHEMBL602123 | N-(2,3,4-trifluoro-5-(2-oxo-2,3-dih...)
Affinity DataIC50:  200nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(CHEMBL598626 | N-(3-tert-butyl-1-phenyl-1H-pyrazol...)
Affinity DataIC50:  202nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(CHEMBL602123 | N-(2,3,4-trifluoro-5-(2-oxo-2,3-dih...)
Affinity DataIC50:  216nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(CHEMBL602123 | N-(2,3,4-trifluoro-5-(2-oxo-2,3-dih...)
Affinity DataIC50:  237nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  584nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(CHEMBL602123 | N-(2,3,4-trifluoro-5-(2-oxo-2,3-dih...)
Affinity DataIC50:  608nMAssay Description:Inhibition of p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  698nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(CHEMBL598626 | N-(3-tert-butyl-1-phenyl-1H-pyrazol...)
Affinity DataIC50:  883nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(CHEMBL598626 | N-(3-tert-butyl-1-phenyl-1H-pyrazol...)
Affinity DataIC50:  1.09E+3nMAssay Description:Inhibition of wild type BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  1.34E+3nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(CHEMBL598626 | N-(3-tert-butyl-1-phenyl-1H-pyrazol...)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(CHEMBL598626 | N-(3-tert-butyl-1-phenyl-1H-pyrazol...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  1.53E+3nMAssay Description:Inhibition of FLT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  1.55E+3nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  1.81E+3nMAssay Description:Inhibition of p38gamma MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  1.84E+3nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(CHEMBL602123 | N-(2,3,4-trifluoro-5-(2-oxo-2,3-dih...)
Affinity DataIC50:  2.17E+3nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(CHEMBL602123 | N-(2,3,4-trifluoro-5-(2-oxo-2,3-dih...)
Affinity DataIC50:  2.39E+3nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50:  3.14E+3nMAssay Description:Inhibition of wild type BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(CHEMBL598626 | N-(3-tert-butyl-1-phenyl-1H-pyrazol...)
Affinity DataIC50:  4.16E+3nMAssay Description:Inhibition of FLT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(CHEMBL598626 | N-(3-tert-butyl-1-phenyl-1H-pyrazol...)
Affinity DataIC50:  4.25E+3nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(CHEMBL602123 | N-(2,3,4-trifluoro-5-(2-oxo-2,3-dih...)
Affinity DataIC50:  4.84E+3nMAssay Description:Inhibition of FLT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(CHEMBL602123 | N-(2,3,4-trifluoro-5-(2-oxo-2,3-dih...)
Affinity DataIC50:  5.02E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(CHEMBL598626 | N-(3-tert-butyl-1-phenyl-1H-pyrazol...)
Affinity DataIC50:  7.49E+3nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(CHEMBL598626 | N-(3-tert-butyl-1-phenyl-1H-pyrazol...)
Affinity DataIC50:  9.71E+3nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of COTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(CHEMBL598626 | N-(3-tert-butyl-1-phenyl-1H-pyrazol...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(CHEMBL602123 | N-(2,3,4-trifluoro-5-(2-oxo-2,3-dih...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(CHEMBL598626 | N-(3-tert-butyl-1-phenyl-1H-pyrazol...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of COTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(CHEMBL602123 | N-(2,3,4-trifluoro-5-(2-oxo-2,3-dih...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of COTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(CHEMBL598626 | N-(3-tert-butyl-1-phenyl-1H-pyrazol...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of p38gamma MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(CHEMBL602123 | N-(2,3,4-trifluoro-5-(2-oxo-2,3-dih...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of p38gamma MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(CHEMBL598626 | N-(3-tert-butyl-1-phenyl-1H-pyrazol...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(CHEMBL602123 | N-(2,3,4-trifluoro-5-(2-oxo-2,3-dih...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed