Compile Data Set for Download or QSAR
maximum 50k data
Found 35 Enz. Inhib. hit(s) with all data for entry = 50031465
TargetBeta-secretase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313806((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313798((2R,4S,5S)-5-((S)-2-((S)-2-acetamido-4-methylpenta...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313805((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50:  25nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313796((2R,4S,5S)-5-((S)-2-((S)-2-acetamidopropanamido)-4...)
Affinity DataIC50:  35nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313797((2R,4S,5S)-5-((S)-2-((S)-2-acetamido-3-methylbutan...)
Affinity DataIC50:  48nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313798((2R,4S,5S)-5-((S)-2-((S)-2-acetamido-4-methylpenta...)
Affinity DataIC50:  53nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313806((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50:  67nMAssay Description:Inhibition of BACE1 expressed in CHO cells co-transfected with human APP assessed as inhibition of cellular release of Abeta 40 after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM16077((2R,4S,5S)-N-butyl-5-[(2S)-2-[(2S)-2-acetamido-4-m...)
Affinity DataIC50:  120nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313806((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50:  120nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313805((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50:  130nMAssay Description:Inhibition of BACE1 expressed in CHO cells co-transfected with human APP assessed as inhibition of cellular release of Abeta 40 after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313806((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50:  140nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313799((1R,3S)-3-((S)-1-acetamido-2-methylpropyl)-N-((2S,...)
Affinity DataIC50:  150nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313804((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50:  150nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313801((1R,3S)-3-(1-acetamidocyclopentyl)-N-((2S,3S,5R)-6...)
Affinity DataIC50:  170nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313799((1R,3S)-3-((S)-1-acetamido-2-methylpropyl)-N-((2S,...)
Affinity DataIC50:  170nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313804((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50:  200nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313800((1R,3S)-3-(2-acetamidopropan-2-yl)-N-((2S,3S,5R)-6...)
Affinity DataIC50:  240nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM16077((2R,4S,5S)-N-butyl-5-[(2S)-2-[(2S)-2-acetamido-4-m...)
Affinity DataIC50:  260nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313797((2R,4S,5S)-5-((S)-2-((S)-2-acetamido-3-methylbutan...)
Affinity DataIC50:  370nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313800((1R,3S)-3-(2-acetamidopropan-2-yl)-N-((2S,3S,5R)-6...)
Affinity DataIC50:  370nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313804((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50:  410nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313805((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50:  560nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313803((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50:  580nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313804((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50:  660nMAssay Description:Inhibition of BACE1 expressed in CHO cells co-transfected with human APP assessed as inhibition of cellular release of Abeta 40 after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313799((1R,3S)-3-((S)-1-acetamido-2-methylpropyl)-N-((2S,...)
Affinity DataIC50:  800nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313805((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50:  960nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313801((1R,3S)-3-(1-acetamidocyclopentyl)-N-((2S,3S,5R)-6...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313801((1R,3S)-3-(1-acetamidocyclopentyl)-N-((2S,3S,5R)-6...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313800((1R,3S)-3-(2-acetamidopropan-2-yl)-N-((2S,3S,5R)-6...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313803((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313802((1R,3S)-3-(2-acetamidopropan-2-yl)-N-((2S,3S)-3-hy...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313796((2R,4S,5S)-5-((S)-2-((S)-2-acetamidopropanamido)-4...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313802((1R,3S)-3-(2-acetamidopropan-2-yl)-N-((2S,3S)-3-hy...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313803((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50313802((1R,3S)-3-(2-acetamidopropan-2-yl)-N-((2S,3S)-3-hy...)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed